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Toluene diisocyanate (26471-62-5)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0024341

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Positive, Male, Rats
View
  • Positive, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Negative, Male, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Toluene diisocyanate (26471-62-5).
Rodent Cytogenetics
CA SCE
  • View
    • Positive (Nonstandard Protocol)
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Toluene diisocyanate (26471-62-5).
Mammalian Cell Cytogenetics
CA SCE
  • View
    • Weakly Positive
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Toluene diisocyanate (26471-62-5).
Drosophila Germ Cell Mutagenicity
SLRL RT
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Toluene diisocyanate (26471-62-5).
Bacterial Mutagenicity
View
  • Positive

Citation Information

NTP. Toluene diisocyanate (26471-62-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-251 Toxicology and Carcinogenesis Studies of Commercial Grade 2,4 (80)- and 2,6 (20)- Toluene Diisocyanate (CASRN 26471-62-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of 2,4- & 2,6-Toluene Diisocyanate (26471-62-5) in Male F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,4- & 2,6-Toluene Diisocyanate (26471-62-5) in Female F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,4- & 2,6-Toluene Diisocyanate (26471-62-5) in Male B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,4- & 2,6-Toluene Diisocyanate (26471-62-5) in Female B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 2,4- & 2,6-Toluene Diisocyanate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 654636
Summary Data

Other NTP Studies

ADME/TK Evaluation (S0057) of 2,4- & 2,6-Toluene diisocyanate (26471-62-5) in F344 Rats Exposed via Gavage Administration
Data Summary

NTP Data Collections