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TR-540: Methylene blue trihydrate (7220-79-3)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Female, Rats
  • Some Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Equivocal Evidence, Female, Mice
  • Some Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to TR-540: Methylene blue trihydrate (7220-79-3).
Micronucleus - Mice
View
  • Male: Negative
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to TR-540: Methylene blue trihydrate (7220-79-3).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TR-540: Methylene blue trihydrate (7220-79-3).
Bacterial Mutagenicity
View
  • Positive
View
  • Positive

Citation Information


NTP. TR-540: Methylene blue trihydrate (7220-79-3). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-540 Toxicology and Carcinogenesis Studies of Methylene Blue Trihydrate (CASRN 7220-79-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Study Data


Toxicity and Carcinogenicity Studies


18-33 Day Evaluation of the Toxicity (C91005) of Methylene Blue Trihydrate (7220-79-3) in F344/N Rats Exposed via Gavage
18-33 Day Evaluation of the Toxicity (C91005) of Methylene Blue Trihydrate (7220-79-3) in B6C3F1 Mice Exposed via Gavage
3-Month Evaluation of the Toxicity (C91005B) of Methylene Blue Trihydrate (7220-79-3) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C91005B) of Methylene Blue Trihydrate (7220-79-3) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C91005B) of Methylene Blue Trihydrate (7220-79-3) in B6C3F1 Mice Exposed via Gavage
3-Month Evaluation of the Toxicity (C91005B) of Methylene Blue Trihydrate (7220-79-3) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C91005C) of Methylene Blue Trihydrate (7220-79-3) in F344/N Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C91005C) of Methylene Blue Trihydrate (7220-79-3) in F344/N Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C91005C) of Methylene Blue Trihydrate (7220-79-3) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C91005C) of Methylene Blue Trihydrate (7220-79-3) in B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Methylene Blue Trihydrate (7220-79-3) in Micronucleus Study A76244 in B6C3F1 Mice
Genetic Toxicity Evaluation of Methylene Blue Trihydrate (7220-79-3) in Micronucleus Study A77225 in B6C3F1 Mice
Genetic Toxicity Evaluation of Methylene Blue Trihydrate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 811345
Summary Data
Genetic Toxicity Evaluation of Methylene Blue Trihydrate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A35880
Summary Data