TR-599: Sodium tungstate dihydrate (10213-10-2)

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to TR-599: Sodium tungstate dihydrate (10213-10-2).
Micronucleus - Mice
View Male: Negative Female: Negative

An overview of Genetic Toxicology Micronucleus Rats study conclusions related to TR-599: Sodium tungstate dihydrate (10213-10-2).
Micronucleus - Rats
View Male: Negative Female: Negative

An overview of Genetic Toxicology In Vivo Alkaline Comet Assay Rats study conclusions related to TR-599: Sodium tungstate dihydrate (10213-10-2).
In Vivo Alkaline Comet Assay - Rats
View Male: Positive Female: Positive

An overview of Genetic Toxicology In Vivo Alkaline Comet Assay Mice study conclusions related to TR-599: Sodium tungstate dihydrate (10213-10-2).
In Vivo Alkaline Comet Assay - Mice
View Male: Positive Female: Negative

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TR-599: Sodium tungstate dihydrate (10213-10-2).
Bacterial Mutagenicity
View Negative

Citation Information

NTP. TR-599: Sodium tungstate dihydrate (10213-10-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

TR-599 Toxicology and Carcinogenesis Studies of Sodium Tungstate Dihydrate in Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice (Drinking Water Studies)

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Data

3-Month Evaluation of the Toxicity (C03038) of Sodium Tungstate Dihydrate (10213-10-2) in Harlan Sprague-Dawley Rats Exposed via Dosed Water

Study Tables

E03 - Growth Curves (73 kB)
E05 - Clinical Observations Summary (14 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (29 kB)
P04 - Neoplasms by Individual Animal (202 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (203 kB)
P14 - Individual Animal Pathology Data (261 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (30 kB)
P40 - Survival Curves (58 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (35 kB)
Female Individual Animal Clinical Observations (4 kB)
Female Individual Animal Non Neoplastic Pathology Data (22 kB)
Female Individual Animal Organ Weight Data (19 kB)
Female Individual Animal Survival Data (11 kB)
Male Individual Animal Body Weight Data (35 kB)
Male Individual Animal Non Neoplastic Pathology Data (26 kB)
Male Individual Animal Organ Weight Data (19 kB)
Male Individual Animal Survival Data (11 kB)

Data

3-Month Evaluation of the Toxicity (C03038) of Sodium Tungstate Dihydrate (10213-10-2) in B6C3F1/N Mice Exposed via Dosed Water

Study Tables

E03 - Growth Curves (66 kB)
E04 - Mean Body Weights and Survival Table (18 kB)
E05 - Clinical Observations Summary (11 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (29 kB)
P04 - Neoplasms by Individual Animal (203 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (204 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (67 kB)
P14 - Individual Animal Pathology Data (261 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (30 kB)
P40 - Survival Curves (58 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (34 kB)
Female Individual Animal Non Neoplastic Pathology Data (13 kB)
Female Individual Animal Organ Weight Data (19 kB)
Female Individual Animal Survival Data (11 kB)
Male Individual Animal Body Weight Data (34 kB)
Male Individual Animal Non Neoplastic Pathology Data (13 kB)
Male Individual Animal Organ Weight Data (19 kB)
Male Individual Animal Survival Data (11 kB)

Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C03038) of Sodium Tungstate Dihydrate (10213-10-2) in Harlan Sprague-Dawley Rats Exposed via Dosed Water

Study Tables

E01 - Animal Removal Summary by Treatment Group (13 kB)
E02 - Animals Removed from Experiment (148 kB)
E03 - Growth Curves Litter Based (63 kB)
E04 - Mean Body Weights and Survival Table Litter Based (19 kB)
E05 - Clinical Observations Summary (22 kB)
E07 - Mean Water Consumption by Treatment Group (26 kB)
E08 - Feed Water and Compound Consumption Table (38 kB)
E12 - Animal History (1 mB)
Gestational Body Weights (20 kB)
Gestational Water Consumption (18 kB)
Gestational/Lactational Chemical Consumption (20 kB)
I05 - Clinical Observations Summary (46 kB)
Lactational Body Weights (21 kB)
Lactational Water Consumption (19 kB)
P02 - Incidence Rates of Neoplasms by Anatomic Site (54 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (67 kB)
P04 - Neoplasms by Individual Animal (663 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (51 kB)
P08 - Statistical Analysis of Primary Tumors (178 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (913 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (535 kB)
P11 - Statistical Analysis of Survival Data (21 kB)
P14 - Individual Animal Pathology Data (1 mB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (594 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (70 kB)
P40 - Survival Curves (487 kB)
PA06_Organ_Weights_Summary (235 kB)
PA48C - Tissue Concentration Curve (4 mB)
PA48_Summary_of_Tissue_Concentration (177 kB)
PND 1 Litter Data (23 kB)
PND 4 Live Litter Size and Survival (24 kB)
Pup Body Weights (cont) (22 kB)
Pup Body Weights (cont) (14 kB)
R02_Reproductive_Performance_Summary (39 kB)

Individual Animal Data

Female Individual Animal Survival Data (34 kB)
Female Individual Animal Terminal Body Weight Data (57 kB)
Female Individual Body Weight Data (49 kB)
Female Individual Body Weight Data (41 kB)
Female Individual Body Weight Data (228 kB)
Female Individual Body Weight Data (393 kB)
Female Individual Clinical Observations Data (206 kB)
Female Neoplastic Pathology Data (110 kB)
Female NonNeoplastic Pathology Data (565 kB)
Individual Animal Clinical Observations Data (10 kB)
Individual Animal DamID and Pup ID Data (30 kB)
Individual Animal Organ Weight Data (28 kB)
Individual Animal Reproductive Performance Data (11 kB)
Individual Animal Tissue Concentration Data (19 kB)
Individual Animal Urinalysis Data (21 kB)
Individual Pup Census and Litter Weight by Sex Data (26 kB)
Male Individual Animal Survival Data (33 kB)
Male Individual Animal Terminal_Body Weight Data (57 kB)
Male Individual Body Weight Data (235 kB)
Male Individual Body Weight Data (397 kB)
Male Individual Clinical Observations Data (183 kB)
Male Neoplastic Pathology Data (107 kB)
Male NonNeoplastic Pathology Data (797 kB)

Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C03038) of Sodium Tungstate Dihydrate (10213-10-2) in B6C3F1/N Mice Exposed via Dosed Water

Study Tables

E01 - Animal Removal Summary by Treatment Group (13 kB)
E02 - Animals Removed from Experiment (110 kB)
E03 - Growth Curves (470 kB)
E04 - Mean Body Weights and Survival Table (24 kB)
E05 - Clinical Observations Summary (20 kB)
E07 - Mean Water Consumption by Treatment Group (25 kB)
E08 - Feed Water and Compound Consumption Table (36 kB)
E12 - Animal History (1 mB)
P02 - Incidence Rates of Neoplasms by Anatomic Site (57 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (64 kB)
P04 - Neoplasms by Individual Animal (734 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (51 kB)
P08 - Statistical Analysis of Primary Tumors (224 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (885 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (564 kB)
P11 - Statistical Analysis of Survival Data (24 kB)
P14 - Individual Animal Pathology Data (1 mB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (608 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (66 kB)
P40 - Survival Curves (453 kB)
PA06_Organ_Weights_Summary (236 kB)
PA48C - Tissue Concentration Curve (3 mB)
PA48_Summary_of_Tissue_Concentration (167 kB)

Individual Animal Data

Female Individual Animal Survival (34 kB)
Female Individual Animal Terminal Body Weight Data (57 kB)
Female Individual Body Weight (320 kB)
Female Individual Clinical Observations (30 kB)
Female Neoplastic Pathology Data (148 kB)
Female NonNeoplastic Pathology Data (520 kB)
Individual Animal Organ Weight Data (25 kB)
Individual Animal Tissue Concentration Data (19 kB)
Individual Animal Urinalysis Data (20 kB)
Male Individual Animal Survival (34 kB)
Male Individual Animal Terminal_Body Weight Data (57 kB)
Male Individual Body Weight (377 kB)
Male Individual Clinical Observations (74 kB)
Male Neoplastic Pathology Data (148 kB)
Male NonNeoplastic Pathology Data (627 kB)

Protocol

Genetic Toxicology Studies

Data

Genetic Toxicity Evaluation of Sodium Tungstate Dihydrate (10213-10-2) in DNA Damage Study G03038F in Harlan Sprague Dawley Rats

Summary and Individual Animal Data

G01 - In Vivo Alkaline Comet Summary Data (70 kB)
Individual Animal In Vivo Alkaline Comet Data (32 kB)

Data

Genetic Toxicity Evaluation of Sodium Tungstate Dihydrate (10213-10-2) in Micronucleus Study G03038B in B6C3F1 Mice

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (79 kB)
Individual Animal In Vivo Micronucleus Data (10 kB)

Data

Genetic Toxicity Evaluation of Sodium Tungstate Dihydrate (10213-10-2) in Micronucleus Study G03038C in Harlan Sprague-Dawley Rats

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (79 kB)
Individual Animal In Vivo Micronucleus Data (10 kB)

Data

Genetic Toxicity Evaluation of Sodium Tungstate Dihydrate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G03038D

Summary Data

G06 - Ames Summary Data (80 kB)

Data

Genetic Toxicity Evaluation of Sodium tungstate dihydrate (10213-10-2) in DNA Damage Study G03038E in B6C3F1 Mice

Summary and Individual Animal Data

G01 - In Vivo Alkaline Comet Summary Data (93 kB)
Individual Animal In Vivo Alkaline Comet Data (23 kB)

TR-599: Sodium tungstate dihydrate (10213-10-2)

Study Results

Genetic Toxicology

Citation Information

Related Links

Publications

Study Data

Toxicity and Carcinogenicity Studies

3-Month Evaluation of the Toxicity (C03038) of Sodium Tungstate Dihydrate (10213-10-2) in Harlan Sprague-Dawley Rats Exposed via Dosed Water

Study Tables

Individual Animal Data

3-Month Evaluation of the Toxicity (C03038) of Sodium Tungstate Dihydrate (10213-10-2) in B6C3F1/N Mice Exposed via Dosed Water

Study Tables

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C03038) of Sodium Tungstate Dihydrate (10213-10-2) in Harlan Sprague-Dawley Rats Exposed via Dosed Water

Study Tables

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C03038) of Sodium Tungstate Dihydrate (10213-10-2) in B6C3F1/N Mice Exposed via Dosed Water

Study Tables

Individual Animal Data

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Sodium Tungstate Dihydrate (10213-10-2) in DNA Damage Study G03038F in Harlan Sprague Dawley Rats

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Sodium Tungstate Dihydrate (10213-10-2) in Micronucleus Study G03038B in B6C3F1 Mice

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Sodium Tungstate Dihydrate (10213-10-2) in Micronucleus Study G03038C in Harlan Sprague-Dawley Rats

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Sodium Tungstate Dihydrate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G03038D

Summary Data

Genetic Toxicity Evaluation of Sodium tungstate dihydrate (10213-10-2) in DNA Damage Study G03038E in B6C3F1 Mice

Summary and Individual Animal Data