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4-Chloronitrobenzene (100-00-5)


Study Results


Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 4-Chloronitrobenzene (100-00-5).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to 4-Chloronitrobenzene (100-00-5).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 4-Chloronitrobenzene (100-00-5).
Bacterial Mutagenicity
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  • Positive
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  • Positive

Citation Information


NTP. 4-Chloronitrobenzene (100-00-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TOX-33 Toxicity Studies of 2-Chloronitrobenzene (CASRN 88-73-3) and 4-Chloronitrobenzene (CASRN 100-00-5) Administered by Inhalation to F344/N Rats and B6C3F1Mice
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C62259) of 4-Chloronitrobenzene (100-00-5) in F344 Rats via Whole Body Respiratory Exposure. NTP Special Study
3-Month Evaluation of the Toxicity (C62259) of 4-Chloronitrobenzene (100-00-5) in B6C3F1 Mice via Whole Body Respiratory Exposure. NTP Special Study
3-Month Evaluation of the Toxicity (C62259) of 4-Chloronitrobenzene (100-00-5) in F344/N Rats via Whole Body Respiratory Exposure
3-Month Evaluation of the Toxicity (C62259) of 4-Chloronitrobenzene (100-00-5) in B6C3F1 Mice via Whole Body Respiratory Exposure

Other NTP Studies


ADME/TK Evaluation (S0077) of 4-Chloronitrobenzene (100-00-5) in F344 Rats Exposed via Topical Application
ADME/TK Evaluation (S0105) of 4-Chloronitrobenzene (100-00-5) in F344 Rats Exposed via Gavage
ADME/TK Evaluation (S0363) of 4-Chloronitrobenzene (100-00-5) in F344 Rats Exposed via Gavage
ADME/TK Evaluation (S0779) of 4-Chloronitrobenzene (100-00-5) in F344 Rats Exposed via Gavage