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Diethanolamine (111-42-2)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Female, Rats
  • No Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Diethanolamine (111-42-2).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Diethanolamine (111-42-2).
Mammalian Cell Mutagenicity
View
  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Diethanolamine (111-42-2).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Diethanolamine (111-42-2).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. Diethanolamine (111-42-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-478 Toxicology and Carcinogenesis Studies of Diethanolamine (CASRN 111-42-2) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
TOX-20 Toxicity Studies of Diethanolamine (CASRN 111-42-2) Administered Topically and in Drinking Water to F344/N Rats and B6C3F1Mice
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Developmental Toxicity Screen for Diethanolamine (CASRN 111-42-2) Administered by Gavage to Sprague-Dawley (CD®) Rats on Gestational Days 6 through 19: Evaluation of Dams and Pups through Postnatal Day 21
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C55174B) of Diethanolamine (111-42-2) in F344/N Rats Exposed via Topical Application
3-Month Evaluation of the Toxicity (C55174C) of Diethanolamine (111-42-2) in F344/N Rats Exposed via Dosed Water
3-Month Evaluation of the Toxicity (C55174B) of Diethanolamine (111-42-2) in B6C3F1 Mice Exposed via Topical Application
3-Month Evaluation of the Toxicity (C55174C) of Diethanolamine (111-42-2) in B6C3F1 Mice Exposed via Dosed Water
Evaluation of the Chronic Toxicity and Carcinogenicity (C55174D) of Diethanolamine (111-42-2) in F344/N Rats Exposed via Topical Application
Evaluation of the Chronic Toxicity and Carcinogenicity (C55174D) of Diethanolamine (111-42-2) in B6C3F1 Mice Exposed via Topical Application

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Diethanolamine (111-42-2) in Micronucleus Study A08796 in B6C3F1 Mice
Genetic Toxicity Evaluation of Diethanolamine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 310797
Summary Data

Other NTP Studies


ADME/TK Evaluation (S0814) of Diethanolamine (111-42-2) in F344 Rats and B6C3F1 Mice Exposed via Gavage, Intravenous Injection or Topical Application
Prenatal Developmental Toxicity Study (TER96001) of Diethanolamine (111-42-2) in Sprague-Dawley Rats Exposed via Gavage