bis(2-Chloroethoxy)methane (111-91-1)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4023917
Study Results
Chronic Bioassay Level of Evidence
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| Mice | |
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Genetic Toxicology
| Micronucleus - Mice |
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| Micronucleus - Rats |
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| Bacterial Mutagenicity |
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Publications
TR-536
Toxicology and Carcinogenesis Studies of bis(2-Chloroethoxy)methane (CASRN 111-91-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
Study Data
Toxicity and Carcinogenicity Studies
2-Week Evaluation of the Toxicity (C99028) of bis(2-Chloroethoxy)methane (111-91-1) in F344/N Rats Exposed via Topical Application
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
2-Week Evaluation of the Toxicity (C99028) of bis(2-Chloroethoxy)methane (111-91-1) in F344/N Rats Exposed via Topical Application
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
2-Week Evaluation of the Toxicity (C99028) of bis(2-Chloroethoxy)methane (111-91-1) in F344/N Rats Exposed via Topical Application. NTP Special Study
3-Month Evaluation of the Toxicity (C99028) of bis(2-Chloroethoxy)methane (111-91-1) in F344 Rats Exposed via Topical Application. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Clinical Chemistry Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C99028) of bis(2-Chloroethoxy)methane (111-91-1) in F344 Rats Exposed via Topical Application. NTP Special Study
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Female Individual Animal Clinical Chemistry Data
- Female Individual Animal Hematology Data
Clinical Chemistry Reports
2-Week Evaluation of the Toxicity (C99028) of bis(2-Chloroethoxy)methane (111-91-1) in B6C3F1 Mice Exposed via Topical Application
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
2-Week Evaluation of the Toxicity (C99028) of bis(2-Chloroethoxy)methane (111-91-1) in B6C3F1 Mice Exposed via Topical Application. NTP Special Study
3-Month Evaluation of the Toxicity (C99028) of bis(2-Chloroethoxy)methane (111-91-1) in B6C3F1 Mice Exposed via Topical Application. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C99028) of bis(2-Chloroethoxy)methane (111-91-1) in F344/N Rats Exposed via Topical Application
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E12 - Animal History
Individual Animal Data
3-Month Evaluation of the Toxicity (C99028) of bis(2-Chloroethoxy)methane (111-91-1) in F344/N Rats Exposed via Topical Application
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C99028) of bis(2-Chloroethoxy)methane (111-91-1) in B6C3F1 Mice Exposed via Topical Application
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Acute Evaluation of the Toxicity (C99028) of bis(2-Chloroethoxy)methane (111-91-1) in F344/N Rats Exposed via Topical Application
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Acute Evaluation of the Toxicity (C99028B) of bis(2-Chloroethoxy)methane (111-91-1) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C99028) of bis(2-Chloroethoxy)methane (111-91-1) in F344/N Rats Exposed via Topical Application
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C99028) of bis(2-Chloroethoxy)methane (111-91-1) in B6C3F1 Mice Exposed via Topical Application
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Genetic Toxicology Studies
Genetic Toxicity Evaluation of bis(2-Chloroethoxy)methane (111-91-1) in Micronucleus Study A22073 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of bis(2-Chloroethoxy)methane (111-91-1) in Micronucleus Study A53820 in F344 Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of bis(2-Chloroethoxy)methane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A20931
Summary Data
- G06 - Ames Summary Data (77 KB)
Genetic Toxicity Evaluation of bis(2-Chloroethoxy)methane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A92025
Summary Data
- G06 - Ames Summary Data (141 KB)
Other NTP Studies
ADME/TK Evaluation (S0816) of bis(2-Chloroethoxy)methane (111-91-1) in F344/N Rats and B6C3F1 Mice Exposed via Gavage, Intravenous Injection or Topical Application
Toxicokinetic Evaluation (C99028) of Bis 2-Chloroethoxy Methane (111-91-1) in F344/N Rats and B6C3F1 Mice Exposed via Topical Application or Intravenous Injection
Data - bis(2-Chloroethoxy)methane and Thiodiglycolic Acid
Data - bis(2-Chloroethoxy)methane
- Data Summary - Mice (305 kB)
- Data Summary - Rats (154 kB)
Data - Thiodiglycolic Acid
- Data Summary - Mice (75 kB)
- Data Summary - Rats (75 kB)
Toxicokinetic Evaluation (K08624) of Bis 2-Chloroethoxy Methane (DTXSID4023917) in Rat and Mouse
Data
- Annotated Group Parameters (45 kB)
- Annotated Individual Animal Data (926 kB)
- Original Data (170 kB)
- Summary Data - Mice, Bis 2-Chloroethoxy Methane (382 kB)
- Summary Data - Mice, Thiodiglycolic Acid (2 mB)
- Summary Data - Rats, Bis 2-Chloroethoxy Methane (277 kB)
- Summary Data - Rats, Thiodiglycolic Acid (195 kB)