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Nickel subsulfide (12035-72-2)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Female, Rats
  • Clear Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Nickel subsulfide (12035-72-2).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Nickel subsulfide (12035-72-2).
Bacterial Mutagenicity
View
  • Equivocal

Citation Information


NTP. Nickel subsulfide (12035-72-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-453 Toxicology and Carcinogenesis Studies of Nickel Subsulfide (CASRN 12035-72-2) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Benson JM, Barr EB, Bechtold WE, Cheng YS. Fate of Inhaled Nickel Oxide and Nickel Subsulfide in F344/N Rats. Inhalation Toxicology, 6:167-183, 1994.

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity (C61654) of Nickel Subsulfide (12035-72-2) in F344/N Rats via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity (C61654) of Nickel Subsulfide (12035-72-2) in B6C3F1 Mice via Whole Body Respiratory Exposure

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Nickel Subsulfide (12035-72-2) in Micronucleus Study A50848 in B6C3F1 Mice
Genetic Toxicity Evaluation of Nickel Subsulfide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 498230
Summary Data

Other NTP Studies


ADME/TK Evaluation (K61654) of Nickel Subsulfide (12035-72-2) in F344/N Rats Exposed via Gavage or Nose-Only Respiratory Exposure