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2-Hydroxy-4-methoxybenzophenone (131-57-7)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID3022405

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 2-Hydroxy-4-methoxybenzophenone (131-57-7).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 2-Hydroxy-4-methoxybenzophenone (131-57-7).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 2-Hydroxy-4-methoxybenzophenone (131-57-7).
Bacterial Mutagenicity
View
  • Weakly Positive
View
  • Negative
View
  • Negative

Citation Information

NTP. 2-Hydroxy-4-methoxybenzophenone (131-57-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-597 NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2-Hydroxy-4-methoxybenzophenone in Harlan Sprague-Dawley Rats
TOX-21 Toxicity Studies of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered Topically and in Dosed Feed to F344/N Rats and B6C3F1Mice
DART-05 NTP Developmental and Reproductive Toxicity Technical Report on the Modified One-Generation Study of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats with Prenatal and Reproductive Performance Assessments in F1 Offspring
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Simultaneous Quantitation of 2-Hydroxy-4-Methoxybenzophenone, a Sunscreen Ingredient, and its Metabolites in Harlan Sprague Dawley Rat Plasma Following Perinatal Dietary Exposure Mutlu E, Pierfelice J, McIntyre BS, Cunny HC, Kissling GE, Burback B, Waidyanatha S.
Journal of Analytical Toxicology (2017) DOI: https://doi.org/10.1093/jat/bkx070 PMID: 28977387

Study Data

Protocol

Toxicity and Carcinogenicity Studies

3-Month Evaluation of the Toxicity (C60957A) of 2-Hydroxy-4-methoxybenzophenone (131-57-7) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C60957B) of 2-Hydroxy-4-methoxybenzophenone (131-57-7) in F344/N Rats Exposed via Topical Application
Pathology Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C60957A) of 2-Hydroxy-4-methoxybenzophenone (131-57-7) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C60957B) of 2-Hydroxy-4-methoxybenzophenone (131-57-7) in B6C3F1 Mice Exposed via Topical Application
Pathology Tables
Individual Animal Data
Evaluation of the Chronic (with Perinatal Exposure) Toxicity and Carcinogenicity (C10260) of 2-Hydroxy-4-methoxybenzophenone (131-57-7 ) in Harlan Sprague-Dawley Rat Exposed via Dosed Feed
Study Tables
Interim of Chronic (with Perinatal Exposure) Study at 3 Months
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C10260) of 2-Hydroxy-4-methoxybenzophenone (131-57-7) in B6C3F1/N Mice Exposed via Dosed Feed
Study Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 2-Hydroxy-4-methoxybenzophenone (131-57-7) in Micronucleus Study A48127 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 2-Hydroxy-4-methoxybenzophenone in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 381877
Summary Data
Genetic Toxicity Evaluation of 2-Hydroxy-4-methoxybenzophenone in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 613844
Summary Data
Genetic Toxicity Evaluation of 2-hydroxy-4-methoxybenzophenone (131-57-7) in Salmonella/E. coli Mutagenicity Test or Ames Test. Study G10260
Summary Data

Other NTP Studies

ADME/TK Evaluation (S0073) of 2-Hydroxy-4-methoxybenzophenone (131-57-7) in F344 Rats Exposed via Gavage Administration, Dermal Application or Intravenous Injection
Data Summary
Modified One Generation (MOG) Dose Range Finding Toxicity Study (MOG002) of 2-Hydroxy-4-methoxybenzophenone (131-57-7) in Harlan Sprague-Dawley Rats Exposed via Dosed Feed
Modified One Generation DRF Study Tables
Modified One Generation DRF Individual Data
Modified One Generation (MOG) Toxicity Study (MOG002B) of 2-Hydroxy-4-methoxybenzophenone (131-57-7) in Harlan Sprague-Dawley Rats Exposed via Dosed Feed
Modified One Generation Study Tables
Modified One Generation Individual Data
Toxicokinetic Evaluation (S0593) of 2-Hydroxy-4-methoxybenzophenone (DTXSID3022405) in Rat and Mouse
Data

NTP Data Collections