U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

N-Phenyl-2-naphthylamine (135-88-6)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4021131

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Male, Rats
View
  • No Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Male, Mice
View
  • Equivocal Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to N-Phenyl-2-naphthylamine (135-88-6).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to N-Phenyl-2-naphthylamine (135-88-6).
Mammalian Cell Cytogenetics
CA SCE
  • View
    • Weakly Positive
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to N-Phenyl-2-naphthylamine (135-88-6).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. N-Phenyl-2-naphthylamine (135-88-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-333 Toxicology and Carcinogenesis Studies of N-Phenyl-2-Naphthylamine (CASRN 135-88-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of N-Phenyl-2-naphthylamine (135-88-6) in Male F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of N-Phenyl-2-naphthylamine (135-88-6) in Female F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of N-Phenyl-2-naphthylamine (135-88-6) in Male B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of N-Phenyl-2-naphthylamine (135-88-6) in Female B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of N-Phenyl-2-naphthylamine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 585564
Summary Data

NTP Data Collections