3'-Azido-3'-deoxythymidine (30516-87-1)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID8020127
Study Results
Chronic Bioassay Level of Evidence
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Genetic Toxicology
| Micronucleus - Mice |
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| Mammalian Cell Cytogenetics | |
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| CA | SCE |
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| Bacterial Mutagenicity |
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Publications
TR-469
Toxicology and Carcinogenesis Studies of AZT (CASRN 30516-87-1) and AZT/ a-Interferon A/D B6C3F1 Mice (Gavage Studies)
TR-522
Toxicology and Carcinogenesis Studies of Transplacental AZT (CASRN 30516-87-1) in Swiss (CD-1®) Mice (in utero Studies)
Phillips, M.D., Nascimbeni, B., Tice, R.R., and Shelby, M.D. Induction of MN in Mouse BM cells: An evaluation of nucleoside analogues used in the treatment of Aids. Environ. Molec. Mutag. Vol. 18 (1991) 168-183
GMM-14
Toxicology and Carcinogenicity Studies of 3´-Azido-3´-Deoxythymidine (AZT) (CAS No. 30516-87-1) in Genetically Modified C3B6.129F1-Trp53tm1Brd N12 Haploinsufficient Mice (In Utero and Postnatal Gavage Study)
Study Data
Toxicity and Carcinogenicity Studies
18-33 Day Evaluation of the Toxicity (C89006) of Interferon AD + 3'-Azido-3'-deoxythymidine (AIDS Initiative) (INTAZTCOMB) in B6C3F1 Mice Exposed via Subcutaneous Injection
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
18-33 Day Evaluation of the Toxicity (C89007) of 3'-Azido-3'-deoxythymidine/2',3'-Dideoxycytidine (AZTDDCCOMB) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C98002) of AZT + Nitazoxanide (AIDS Initiative) (AZT+NITAZOX) in B6C3F1 Mice Exposed via Gavage. NTP Special Study
26-39 Week Evaluation of the Toxicity (C20310C) of 3'-Azido-3'-deoxythymidine (AIDS) (30516-87-1) in C3B6F1-+/Trp53(tm1Brd) Mice Exposed via Gavage
26-39 Week Evaluation of the Toxicity (C20310C) of 3'-Azido-3'-deoxythymidine (AIDS) (30516-87-1) in C3B6F1-+/Trp53(tm1Brd) Mice Exposed via Gavage
3-Month Evaluation of the Toxicity (C88072) of 3'-Azido-3'-deoxythymidine (AIDS) (30516-87-1) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C88072) of 3'-Azido-3'-deoxythymidine (AIDS) (30516-87-1) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
19-Month (with Perinatal Exposure) Evaluation of the Toxicity (C99022) of AZT transplacental carcinogenesis study (30516-87-1) in SWISS Mice via In-Utero Exposure
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C88072) of 3'-Azido-3'-deoxythymidine (AIDS) (30516-87-1) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C89006) of Interferon AD + 3'-Azido-3'-deoxythymidine (AIDS Initiative) (INTAZTCOMB) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C89006) of Interferon AD + 3'-Azido-3'-deoxythymidine (AIDS Initiative) (INTAZTCOMB) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Genetic Toxicology Studies
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AIDS) (30516-87-1) in Micronucleus Study 912603 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AIDS) (30516-87-1) in Micronucleus Study A88072 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AIDS) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 860655
Summary Data
- G06 - Ames Summary Data (148 KB)
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AIDS) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G88195
Summary Data
- G06 - Ames Summary Data (96 KB)
Other NTP Studies
28-Day Immunotoxicity Evaluation (IMM96013) of AZT + Pyrimethamine Combination (Aids) (AZT/PYRIMETH) in B6C3F1 Mice via Gavage
B6CF1 Mice Individual and Summary Data
- Absolute Leukocyte Differentials (14 kB)
- Body Weights (52 kB)
- Hematology (17 kB)
- In Vitro Cytotoxic T Lymphocyte (CTL) Assay (16 kB)
- Mixed Leukocyte Response (12 kB)
- Natural Killer Activity (18 kB)
- Organ Weights (19 kB)
- Reticulocytes (10 kB)
- Reticuloendothelial System (25 kB)
- Serum IgM (17 kB)
- T-Dependent AB Response Day 4 (26 kB)
Toxicokinetic Evaluation (K88072) of 3'-Azido-3'-deoxythimidine (AZT) (DTXSID8020127) in Rat
Data
- Annotated Group Parameters (14 kB)
- Annotated Individual Animal Data (118 kB)
- Data Summary (332 kB)
Toxicokinetic Evaluation (K88072B) of 3'-Azido-3'-deoxythimidine (AZT) (DTXSID8020127) in Rat
Data
- Annotated Group Parameters (14 kB)
- Annotated Individual Animal Data (99 kB)
- Data Summary (2 mB)
Toxicokinetic Evaluation (S0305) of 3'-Azido-3'-deoxythymidine and Methadone Hydrochloride (AZTMETHCOMB) in B6C3F1 and CD-1 Mice Exposed via Intravenous Injection or Gavage
Data - Methadone Hydrochloride (HCl)
- Data Summary (Female) (56 kB)
- Data Summary (Male) (63 kB)
Data - 3'-Azido-3'-deoxythymidine (AZT), AZT + Methadone HCl, and Methadone Hydrochloride (HCl)
- Data Summary (Female 1991) (57 kB)
- Data Summary (Female 1992) (63 kB)
- Data Summary (Male, Female 1991) (62 kB)
- Individual Animal Data (Female 1992) (38 kB)
- Individual Animal Data (Male, Female 1991) (73 kB)
Data - 3'-Azido-3'-deoxythymidine (AZT)
- Data Summary (Female) (57 kB)
- Data Summary (Male) (63 kB)
Toxicokinetic Evaluation (S0553) of AZT + Rifampin (AIDS Initiative) (DTXSID6021244) in Mouse
Data - 3'-Azido-3'-deoxythymidine and 3'-Azido-3'-deoxythymidine + Rifampicin
- Annotated Group Parameters (17 kB)
- Annotated Individual Animal Data (160 kB)
- Original Data (75 kB)
Data - 3'-Azido-3'-deoxythymidine + Rifampicin
- Summary Data (138 kB)
Data - 3'-Azido-3'-deoxythymidine
- Summary Data (155 kB)
Toxicokinetic Evaluation (S0609) of 3'-Azido-3'-deoxythymidine (30516-87-1) and 3'-Azido-3'-deoxythymidine + Trimethoprim and Sulfamethoxazole (AZTTMPSMX) in B6C3F1 Mice Exposed via Intravenous Injection or Gavage
Data - AZT + TMP/SMX (Mixture) Combination
- Data Summary (Multiple-Dose Gavage) (125 kB)
- Data Summary (Single-Dose Gavage followed by IV) (123 kB)
- Data Summary (Single-Dose Gavage) (127 kB)
Data - 3'-Azido-3'-deoxythymidine and AZT + TMP/SMX (Mixture) Combination
- Individual Animal Data (713 kB)
Data - 3'-Azido-3'-deoxythymidine (AZT)
- Data Summary (127 kB)
Toxicokinetic Evaluation (S0610) of 3'-Azido-3'-deoxythymidine (30516-87-1) and 3'-Azido-3'-deoxythymidine + Trimethoprim and Sulfamethoxazole (AZTTMPSMX) in B6C3F1 Mice Exposed via Gavage
Toxicokinetic Evaluation (S0643) of AZT + Rifampin (AIDS Initiative) (DTXSID6021244) in Mouse
Data - 3'-Azido-3'-deoxythymidine and 3'-Azido-3'-deoxythymidine + Rifampicin
- Annotated Group Parameters (25 kB)
- Annotated Individual Animal Data (468 kB)
- Original Data (168 kB)
Data - 3'-Azido-3'-deoxythymidine (AZT) + Rifampicin
- Summary Data (241 kB)
Data - 3'-Azido-3'-deoxythymidine
- Summary Data (159 kB)
Toxicokinetic Evaluation (S0874) of AZT transplacental carcinogenesis study (DTXSID8020127) in Rat
Data
- Annotated Group Parameters (19 kB)
- Annotated Individual Animal Data (212 kB)
- Data Summary (224 kB)
- Original Data (66 kB)