COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:

5-Azacytidine (320-67-2)

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Inadequate Study, Male, Rats
View
  • Inadequate Study, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Inadequate Study, Male, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 5-Azacytidine (320-67-2).
Micronucleus - Mice
View
  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 5-Azacytidine (320-67-2).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 5-Azacytidine (320-67-2).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 5-Azacytidine (320-67-2).
Bacterial Mutagenicity
View
  • Positive
View
  • Positive

Citation Information

NTP. 5-Azacytidine (320-67-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-042 Bioassay of 5-Azacytidine for Possible Carcinogenicity (CASRN 320-67-2)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of 5-Azacytidine (320-67-2) in Male Sprague-Dawley Rats Exposed via Intraperitoneal Injection
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 5-Azacytidine (320-67-2) in Female Sprague-Dawley Rats Exposed via Intraperitoneal Injection
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 5-Azacytidine (320-67-2) in Male B6C3F1 Mice Exposed via Intraperitoneal Injection
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 5-Azacytidine (320-67-2) in Female B6C3F1 Mice Exposed via Intraperitoneal Injection
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 5-Azacytidine (320-67-2) in Micronucleus Study A95392 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 5-Azacytidine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 440974
Summary Data
Genetic Toxicity Evaluation of 5-Azacytidine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A21960
Summary Data

NTP Data Collections