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2,2-bis(Bromomethyl)-1,3-propanediol (3296-90-0)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Clear Evidence, Female, Rats
  • Clear Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 2,2-bis(Bromomethyl)-1,3-propanediol (3296-90-0).
Micronucleus - Mice
View
  • Male: Equivocal
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 2,2-bis(Bromomethyl)-1,3-propanediol (3296-90-0).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 2,2-bis(Bromomethyl)-1,3-propanediol (3296-90-0).
Bacterial Mutagenicity
View
  • Negative
View
  • Positive
View
  • Positive

Citation Information


NTP. 2,2-bis(Bromomethyl)-1,3-propanediol (3296-90-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-452 Toxicology and Carcinogenesis Studies of 2,2-Bis(Bromomethyl)-1,3-Propanediol (FR-1138 ®) (CASRN 3296-90-0) in F344 Rats and B6C3F1 Mice (Feed Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C55516B) of 2,2-bis(Bromomethyl)-1,3-propanediol (3296-90-0) in F344/N Rats Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C55516B) of 2,2-bis(Bromomethyl)-1,3-propanediol (3296-90-0) in B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity (C55516C) of 2,2-bis(Bromomethyl)-1,3-propanediol (3296-90-0) in F344/N Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity (C55516C) of 2,2-bis(Bromomethyl)-1,3-propanediol (3296-90-0) in B6C3F1 Mice Exposed via Dosed Feed

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 2,2-bis(Bromomethyl)-1,3-propanediol (3296-90-0) in Micronucleus Study 303529 in B6C3F1 Mice
Genetic Toxicity Evaluation of 2,2-bis(Bromomethyl)-1,3-propanediol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 380647
Summary Data
Genetic Toxicity Evaluation of 2,2-bis(Bromomethyl)-1,3-propanediol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 933355
Summary Data
Genetic Toxicity Evaluation of 2,2-bis(Bromomethyl)-1,3-propanediol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A70660
Summary Data