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Procarbazine hydrochloride (366-70-1)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID3021190

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Positive, Male, Rats
View
  • Positive, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Positive, Male, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Procarbazine hydrochloride (366-70-1).
Mammalian Cell Mutagenicity
View
  • Positive
View
  • Positive
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Procarbazine hydrochloride (366-70-1).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. Procarbazine hydrochloride (366-70-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-019 Bioassay of Procarbazine for Possible Carcinogenicity (CASRN 366-70-1)
EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of Procarbazine Hydrochloride (366-70-1) in Male Sprague-Dawley Rats Exposed via Intraperitoneal Injection
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Procarbazine Hydrochloride (366-70-1) in Male Sprague-Dawley Rats Exposed via Intraperitoneal Injection
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Procarbazine Hydrochloride (366-70-1) in Female Sprague-Dawley Rats Exposed via Intraperitoneal Injection
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Procarbazine Hydrochloride (366-70-1) in Female Sprague-Dawley Rats Exposed via Intraperitoneal Injection
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Procarbazine Hydrochloride (366-70-1) in Male B6C3F1 Mice Exposed via Intraperitoneal Injection
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Procarbazine Hydrochloride (366-70-1) in Female B6C3F1 Mice Exposed via Intraperitoneal Injection
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Procarbazine Hydrochloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 557891
Summary Data

DTT Data Collections