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Urethane (51-79-6)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Urethane (51-79-6).
Micronucleus - Mice
View
  • Male: Positive
    Female: Positive
View
  • Male: Negative
View
  • Male: Positive
    Female: Positive
View
  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Urethane (51-79-6).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Urethane (51-79-6).
Drosophila Germ Cell Mutagenicity
SLRL RT
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Urethane (51-79-6).
Bacterial Mutagenicity
View
  • Positive
View
  • Equivocal

Citation Information


NTP. Urethane (51-79-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-510 Toxicology and Carcinogenesis Studies of Urethane + Ethanol (CASRNs 51-79-6 & 64-17-5) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
TOX-52 Toxicity Studies of Urethane in Drinking Water and Urethane in 5% Ethanol in F344/N Rats and B6C3F1Mice (CASRN 51-79-6)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C00602B) of Urethane (51-79-6) in F344 Rats Exposed via Dosed Water. NTP Special Study
3-Month Evaluation of the Toxicity (C00602B) of Urethane (51-79-6) in B6C3F1 Mice Exposed via Dosed Water. NTP Special Study
3-Month Evaluation of the Toxicity (C00602B) of Urethane (51-79-6) in F344/N Rats Exposed via Dosed Water
3-Month Evaluation of the Toxicity (C00602B) of Urethane (51-79-6) in B6C3F1 Mice Exposed via Dosed Water
Evaluation of the Chronic Toxicity and Carcinogenicity of Urethane (51-79-6) in Female B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-) Mice Exposed via Dosed Water

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Urethane (51-79-6) in Micronucleus Study A06541 in B6C3F1 Mice
Genetic Toxicity Evaluation of Urethane (51-79-6) in Micronucleus Study A36432 in B6C3F1 Mice
Genetic Toxicity Evaluation of Urethane (51-79-6) in Micronucleus Study A44972 in B6C3F1 Mice
Genetic Toxicity Evaluation of Urethane (51-79-6) in Micronucleus Study A86637 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Urethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 113016
Summary Data
Genetic Toxicity Evaluation of Urethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 588195
Summary Data

Other NTP Studies


2-Week Immunotoxicity Evaluation (IMM83002) of Urethane (51-79-6) in Female B6C3F1 Mice Exposed via Subcutaneous Injection
ADME/TK Evaluation (S0768) of Urethane (51-79-6) in F344 Rats and B6C3F1 Mice Exposed via Gavage or Intravenous Injection