1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)-ethanone (54464-57-2)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID7031290
Publications
TOX-92
NTP Technical Report on the Toxicity Studies of Octahydro-tetramethyl-naphthalenyl-ethanone (OTNE) Administered Dermally to F344/NTac Rats and B6C3F1/N Mice
Study Data
Toxicity and Carcinogenicity Studies
3-Month Evaluation of the Toxicity (C20307) of Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) (54464-57-2) in F344/NTac Rats Exposed via Topical Application
Study Tables
- E03 - Growth Curves (63 kB)
- E04 - Mean Body Weights and Survival Table (23 kB)
- E05 - Clinical Observations Summary (19 kB)
- E09 - Summary of Dermal Clinical Observations at Site Of Application (12 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (56 kB)
- P04 - Neoplasms by Individual Animal (269 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (57 kB)
- P08 - Statistical Analysis of Primary Tumors (Untreated + High Dose) (111 kB)
- P08 - Statistical Analysis of Primary Tumors (Without High Dose) (104 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (283 kB)
- P14 - Individual Animal Pathology Data (343 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (58 kB)
- P40 - Survival Curves (59 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (40 kB)
- Female Individual Animal Clinical Observations (3 kB)
- Female Individual Animal Non Neoplastic Pathology Data (48 kB)
- Female Individual Animal Organ Weight Data (30 kB)
- Female Individual Animal Survival Data (13 kB)
- Male Individual Animal Body Weight Data (40 kB)
- Male Individual Animal Clinical Observations (3 kB)
- Male Individual Animal Non Neoplastic Pathology Data (51 kB)
- Male Individual Animal Organ Weight Data (30 kB)
- Male Individual Animal Survival Data (13 kB)
3-Month Evaluation of the Toxicity (C20307) of Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) (54464-57-2) in B6C3F1 Mice Exposed via Topical Application
Study Tables
- E03 - Growth Curves (66 kB)
- E04 - Mean Body Weights and Survival Table (23 kB)
- E05 - Clinical Observations Summary (19 kB)
- E09 - Summary of Dermal Clinical Observations at Site Of Application (15 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (56 kB)
- P04 - Neoplasms by Individual Animal (275 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (57 kB)
- P08 - Statistical Analysis of Primary Tumors (Untreated + High Dose) (109 kB)
- P08 - Statistical Analysis of Primary Tumors (Without High Dose) (107 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (291 kB)
- P14 - Individual Animal Pathology Data (351 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (58 kB)
- P40 - Survival Curves (58 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (39 kB)
- Female Individual Animal Clinical Observations (24 kB)
- Female Individual Animal Non Neoplastic Pathology Data (92 kB)
- Female Individual Animal Organ Weight Data (30 kB)
- Female Individual Animal Survival Data (13 kB)
- Male Individual Animal Body Weight Data (39 kB)
- Male Individual Animal Clinical Observations (30 kB)
- Male Individual Animal Neoplastic Pathology Data (2 kB)
- Male Individual Animal Non Neoplastic Pathology Data (87 kB)
- Male Individual Animal Organ Weight Data (30 kB)
- Male Individual Animal Survival Data (13 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) (54464-57-2) in Micronucleus Study F28470 in F344/NTac Rats
Genetic Toxicity Evaluation of Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) (54464-57-2) in Micronucleus Study F35719 in B6C3F1 Mice
Genetic Toxicity Evaluation of Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A39068
Summary Data
- G06 - Ames Summary Data (58 KB)
Genetic Toxicity Evaluation of Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G99091
Summary Data
- G06 - Ames Summary Data (76 KB)