U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

2',3'-Dideoxyinosine (69655-05-6)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID6022927

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 2',3'-Dideoxyinosine (69655-05-6).
Micronucleus - Mice
View
  • Male: Negative
View
  • Male: Negative
View
  • Male: Negative
View
  • Female: Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 2',3'-Dideoxyinosine (69655-05-6).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 2',3'-Dideoxyinosine (69655-05-6).
Bacterial Mutagenicity
View
  • Weakly Positive

Citation Information

NTP. 2',3'-Dideoxyinosine (69655-05-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

Witt KL, Tice RR, Wolfe GW, Bishop JB. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment. Environ Mol Mutagen. 2004;44(4):321-8.
Phillips, M.D., Nascimbeni, B., Tice, R.R., and Shelby, M.D. Induction of MN in Mouse BM cells: An evaluation of nucleoside analogues used in the treatment of Aids. Environ. Molec. Mutag. Vol. 18 (1991) 168-183

Study Data

Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 2',3'-Dideoxyinosine (AIDS Initiative) (69655-05-6) in Micronucleus Study 865388 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 2',3'-Dideoxyinosine (AIDS Initiative) (69655-05-6) in Micronucleus Study A08622 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 2',3'-Dideoxyinosine (AIDS Initiative) (69655-05-6) in Micronucleus Study A20001 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 2',3'-Dideoxyinosine (AIDS Initiative) (69655-05-6) in Micronucleus Study A90144 in CD-1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 2',3'-Dideoxyinosine (AIDS Initiative) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 783382
Summary Data

Other NTP Studies

180-Day Immunotoxicity Evaluation (IMM94006) of 2',3'-Dideoxyinosine (Aids Initiative) (69655-05-6) in B6C3F1 Mice via Gavage
B6CF1 Mice Individual and Summary Data
Toxicokinetic Evaluation (K88074) of 2',3'-Dideoxyinosine (DDI) (DTXSID6022927) in Mouse
Data

NTP Data Collections