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1,1,1-Trichloroethane (71-55-6)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0021381

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Inadequate Study, Male, Rats
View
  • Inadequate Study, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Inadequate Study, Male, Mice
View
  • Inadequate Study, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 1,1,1-Trichloroethane (71-55-6).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
View
  • Male: Equivocal
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 1,1,1-Trichloroethane (71-55-6).
Mammalian Cell Mutagenicity
View
  • Negative
View
  • Equivocal
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 1,1,1-Trichloroethane (71-55-6).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 1,1,1-Trichloroethane (71-55-6).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative
View
  • Negative
View
  • Negative

Citation Information

NTP. 1,1,1-Trichloroethane (71-55-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-003 Bioassay of 1,1,1-Trichloroethane for Possible Carcinogenicity (CASRN 71-55-6)
TOX-41 Toxicity Studies of 1,1,1-Trichloroethane (CASRN 71-55-6)
TOX-45 Renal Toxicity Studies of Selected Halogenated Ethanes Administered by Gavage to F344/N Rats
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Developmental Toxicity Evaluation of 1,1,1-Trichloroethane Administered in Drinking Water to CD Rats (Part II)
Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data

Protocol

Toxicity and Carcinogenicity Studies

3-Month Evaluation of the Toxicity (C04626C) of 1,1,1-Trichloroethane (71-55-6) in F344 Rats Exposed via Microcapsules in Feed. NTP Special Study
Pathology Tables
Individual Animal Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C04626C) of 1,1,1-Trichloroethane (71-55-6) in B6C3F1 Mice Exposed via Microcapsules in Feed. NTP Special Study
Pathology Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C04626) of 1,1,1-Trichloroethane (71-55-6) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C04626C) of 1,1,1-Trichloroethane (71-55-6) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C04626C) of 1,1,1-Trichloroethane (71-55-6) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,1,1-Trichloroethane (71-55-6) in Male Osborne-Mendel Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,1,1-Trichloroethane (71-55-6) in Female Osborne-Mendel Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,1,1-Trichloroethane (71-55-6) in Male B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,1,1-Trichloroethane (71-55-6) in Female B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 1,1,1-Trichloroethane (71-55-6) in Micronucleus Study A09633 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 1,1,1-Trichloroethane (71-55-6) in Micronucleus Study B09633 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 1,1,1-Trichloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 098436
Summary Data
Genetic Toxicity Evaluation of 1,1,1-Trichloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 677121
Summary Data
Genetic Toxicity Evaluation of 1,1,1-Trichloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 797607
Summary Data
Genetic Toxicity Evaluation of 1,1,1-Trichloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 844035
Summary Data

Other NTP Studies

ADME/TK Evaluation (S0091) of 1,1,1-Trichloroethane (71-55-6) in F344 Rats and B6C3F1 Mice Exposed via Gavage Administration and Intravenous Injection
Data Summary
Prenatal Developmental Toxicity Study (T0179) of 1,1,1-Trichloroethane (71-55-6) in Sprague-Dawley Rats Exposed via Dosed Water
Individual and Summary Data

DTT Data Collections