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TOX-45: 1,1,2,2-Tetrachloroethane (79-34-5), Pentachloroethane (76-01-7), Pentabromoethane (75-95-6), 1,1,1-Trichloroethane (71-55-6), Hexachloroethane (67-72-1), 5-Bromo-2'-deoxyuridine (59-14-3), Colchicine (64-86-8), 1,1,1,2-Tetrachloroethane (630-20-6), 1,1,1,2-Tetrabromoethane (630-16-0), 1,2-Difluoro-1,1,2,2-tetrachloroethane (76-12-0), 1,1,2,2-Tetrabromoethane (79-27-6)


Study Results


Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to TOX-45: 1,1,2,2-Tetrachloroethane (79-34-5), Pentachloroethane (76-01-7), Pentabromoethane (75-95-6), 1,1,1-Trichloroethane (71-55-6), Hexachloroethane (67-72-1), 5-Bromo-2'-deoxyuridine (59-14-3), Colchicine (64-86-8), 1,1,1,2-Tetrachloroethane (630-20-6), 1,1,1,2-Tetrabromoethane (630-16-0), 1,2-Difluoro-1,1,2,2-tetrachloroethane (76-12-0), 1,1,2,2-Tetrabromoethane (79-27-6).
Rodent Cytogenetics
CA SCE
  • View
    • Negative (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to TOX-45: 1,1,2,2-Tetrachloroethane (79-34-5), Pentachloroethane (76-01-7), Pentabromoethane (75-95-6), 1,1,1-Trichloroethane (71-55-6), Hexachloroethane (67-72-1), 5-Bromo-2'-deoxyuridine (59-14-3), Colchicine (64-86-8), 1,1,1,2-Tetrachloroethane (630-20-6), 1,1,1,2-Tetrabromoethane (630-16-0), 1,2-Difluoro-1,1,2,2-tetrachloroethane (76-12-0), 1,1,2,2-Tetrabromoethane (79-27-6).
Micronucleus - Mice
View
  • Male: Negative
View
  • Male: Equivocal
    Female: Negative
View
  • Male: Equivocal
    Female: Positive
View
  • Male: Negative
    Female: Negative
View
  • Male: Positive
View
  • Male: Positive
    Female: Positive
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to TOX-45: 1,1,2,2-Tetrachloroethane (79-34-5), Pentachloroethane (76-01-7), Pentabromoethane (75-95-6), 1,1,1-Trichloroethane (71-55-6), Hexachloroethane (67-72-1), 5-Bromo-2'-deoxyuridine (59-14-3), Colchicine (64-86-8), 1,1,1,2-Tetrachloroethane (630-20-6), 1,1,1,2-Tetrabromoethane (630-16-0), 1,2-Difluoro-1,1,2,2-tetrachloroethane (76-12-0), 1,1,2,2-Tetrabromoethane (79-27-6).
Mammalian Cell Mutagenicity
View
  • Positive
View
  • Negative
View
  • Negative
View
  • Negative
View
  • Positive
View
  • Equivocal
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to TOX-45: 1,1,2,2-Tetrachloroethane (79-34-5), Pentachloroethane (76-01-7), Pentabromoethane (75-95-6), 1,1,1-Trichloroethane (71-55-6), Hexachloroethane (67-72-1), 5-Bromo-2'-deoxyuridine (59-14-3), Colchicine (64-86-8), 1,1,1,2-Tetrachloroethane (630-20-6), 1,1,1,2-Tetrabromoethane (630-16-0), 1,2-Difluoro-1,1,2,2-tetrachloroethane (76-12-0), 1,1,2,2-Tetrabromoethane (79-27-6).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to TOX-45: 1,1,2,2-Tetrachloroethane (79-34-5), Pentachloroethane (76-01-7), Pentabromoethane (75-95-6), 1,1,1-Trichloroethane (71-55-6), Hexachloroethane (67-72-1), 5-Bromo-2'-deoxyuridine (59-14-3), Colchicine (64-86-8), 1,1,1,2-Tetrachloroethane (630-20-6), 1,1,1,2-Tetrabromoethane (630-16-0), 1,2-Difluoro-1,1,2,2-tetrachloroethane (76-12-0), 1,1,2,2-Tetrabromoethane (79-27-6).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TOX-45: 1,1,2,2-Tetrachloroethane (79-34-5), Pentachloroethane (76-01-7), Pentabromoethane (75-95-6), 1,1,1-Trichloroethane (71-55-6), Hexachloroethane (67-72-1), 5-Bromo-2'-deoxyuridine (59-14-3), Colchicine (64-86-8), 1,1,1,2-Tetrachloroethane (630-20-6), 1,1,1,2-Tetrabromoethane (630-16-0), 1,2-Difluoro-1,1,2,2-tetrachloroethane (76-12-0), 1,1,2,2-Tetrabromoethane (79-27-6).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative
View
  • Negative
View
  • Negative
View
  • Negative
View
  • Weakly Positive
View
  • Weakly Positive
View
  • Negative
View
  • Negative
View
  • Negative
View
  • Negative
View
  • Negative
View
  • Negative
View
  • Negative
View
  • Negative

Citation Information


NTP. TOX-45: 1,1,2,2-Tetrachloroethane (79-34-5), Pentachloroethane (76-01-7), Pentabromoethane (75-95-6), 1,1,1-Trichloroethane (71-55-6), Hexachloroethane (67-72-1), 5-Bromo-2'-deoxyuridine (59-14-3), Colchicine (64-86-8), 1,1,1,2-Tetrachloroethane (630-20-6), 1,1,1,2-Tetrabromoethane (630-16-0), 1,2-Difluoro-1,1,2,2-tetrachloroethane (76-12-0), 1,1,2,2-Tetrabromoethane (79-27-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TOX-45 Renal Toxicity Studies of Selected Halogenated Ethanes Administered by Gavage to F344/N Rats

Study Data


Genetic Toxicology Studies


Genetic Toxicity Evaluation of 1,1,1,2-Tetrabromoethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A87711
Summary Data
Genetic Toxicity Evaluation of 1,1,1,2-Tetrachloroethane (630-20-6) in Micronucleus Study 299785 in B6C3F1 Mice
Genetic Toxicity Evaluation of 1,1,1,2-Tetrachloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 466226
Summary Data
Genetic Toxicity Evaluation of 1,1,1,2-Tetrachloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 806178
Summary Data
Genetic Toxicity Evaluation of 1,1,1-Trichloroethane (71-55-6) in Micronucleus Study A09633 in B6C3F1 Mice
Genetic Toxicity Evaluation of 1,1,1-Trichloroethane (71-55-6) in Micronucleus Study B09633 in B6C3F1 Mice
Genetic Toxicity Evaluation of 1,1,1-Trichloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 098436
Summary Data
Genetic Toxicity Evaluation of 1,1,1-Trichloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 677121
Summary Data
Genetic Toxicity Evaluation of 1,1,1-Trichloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 797607
Summary Data
Genetic Toxicity Evaluation of 1,1,1-Trichloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 844035
Summary Data
Genetic Toxicity Evaluation of 1,1,2,2-Tetrabromoethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 612759
Summary Data
Genetic Toxicity Evaluation of 1,1,2,2-Tetrachloroethane (79-34-5) in Micronucleus Study A72450 in B6C3F1 Mice
Genetic Toxicity Evaluation of 1,1,2,2-Tetrachloroethane (79-34-5) in Micronucleus Study B72450 in B6C3F1 Mice
Genetic Toxicity Evaluation of 1,1,2,2-Tetrachloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 547949
Summary Data
Genetic Toxicity Evaluation of 1,1,2,2-Tetrachloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 866388
Summary Data
Genetic Toxicity Evaluation of 1,2-Difluoro-1,1,2,2-tetrachloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A88735
Summary Data
Genetic Toxicity Evaluation of Hexachloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 188925
Summary Data
Genetic Toxicity Evaluation of Hexachloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 248997
Summary Data
Genetic Toxicity Evaluation of Pentabromoethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A80503
Summary Data
Genetic Toxicity Evaluation of Pentachloroethane (76-01-7) in Micronucleus Study A48831 in B6C3F1 Mice
Genetic Toxicity Evaluation of Pentachloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 926918
Summary Data