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Nitromethane (75-52-5)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Clear Evidence, Female, Rats
  • No Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Nitromethane (75-52-5).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Nitromethane (75-52-5).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Nitromethane (75-52-5).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. Nitromethane (75-52-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-461 Toxicology and Carcinogenesis Studies of Nitromethane (CASRN 75-52-5) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C61927) of Nitromethane (75-52-5) in F344/N Rats via Whole Body Respiratory Exposure
3-Month Evaluation of the Toxicity (C61927) of Nitromethane (75-52-5) in B6C3F1 Mice via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity (C61927) of Nitromethane (75-52-5) in F344/N Rats via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity (C61927) of Nitromethane (75-52-5) in B6C3F1 Mice via Whole Body Respiratory Exposure

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Nitromethane (75-52-5) in Micronucleus Study A55749 in B6C3F1 Mice
Genetic Toxicity Evaluation of Nitromethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 860172
Summary Data