tert-Butyl alcohol (75-65-0)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID8020204
Study Results
Chronic Bioassay Level of Evidence
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Genetic Toxicology
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| Micronucleus - Rats |
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| Mammalian Cell Mutagenicity |
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| Mammalian Cell Cytogenetics | |
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| CA | SCE |
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| Bacterial Mutagenicity |
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Publications
TR-436
Toxicology and Carcinogenesis Studies of t-Butyl Alcohol (CASRN 75-65-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
TOX-53
Toxicity Studies oft-Butyl Alcohol Administered in F344/N Rats and B6C3F1Mice (Inhalation Studies) (CASRN 75-65-0)
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
Study Data
Toxicity and Carcinogenicity Studies
18-Day Evaluation of the Toxicity (C55367C) of tert-Butyl Alcohol (75-65-0) in F344 Rats via Whole Body Respiratory Exposure. NTP Special Study
18-Day Evaluation of the Toxicity (C55367C) of tert-Butyl Alcohol (75-65-0) in B6C3F1 Mice via Whole Body Respiratory Exposure. NTP Special Study
3-Month Evaluation of the Toxicity (C55367C) of tert-Butyl Alcohol (75-65-0) in F344 Rats via Whole Body Respiratory Exposure. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Clinical Chemistry Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C55367C) of tert-Butyl Alcohol (75-65-0) in B6C3F1 Mice via Whole Body Respiratory Exposure. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C55367B) of tert-Butyl Alcohol (75-65-0) in F344/N Rats Exposed via Dosed Water
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C55367C) of tert-Butyl Alcohol (75-65-0) in F344/N Rats via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C55367B) of tert-Butyl Alcohol (75-65-0) in B6C3F1 Mice Exposed via Dosed Water
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C55367C) of tert-Butyl Alcohol (75-65-0) in B6C3F1 Mice via Whole Body Respiratory Exposure
Pathology Tables
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C55367B) of tert-Butyl Alcohol (75-65-0) in F344/N Rats Exposed via Dosed Water
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C55367B) of tert-Butyl Alcohol (75-65-0) in B6C3F1 Mice Exposed via Dosed Water
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Genetic Toxicology Studies
Cytogenetic Study of tert-Butyl Alcohol in Chinese Hamster Ovary Cell Sister Chromatid Exchange Test
Genetic Toxicity Evaluation of tert-Butyl Alcohol (75-65-0) in Micronucleus Study A00971 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of tert-Butyl Alcohol (75-65-0) in Micronucleus Study A26596 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of tert-Butyl Alcohol (75-65-0) in Micronucleus Study A50244 in F344 Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of tert-Butyl Alcohol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 875987
Summary Data
- G06 - Ames Summary Data (128 KB)