U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

4,4'-Sulfonyldianiline (80-08-0)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4020371

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Positive, Male, Rats
View
  • Negative, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Negative, Male, Mice
View
  • Negative, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 4,4'-Sulfonyldianiline (80-08-0).
Mammalian Cell Mutagenicity
View
  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 4,4'-Sulfonyldianiline (80-08-0).
Mammalian Cell Cytogenetics
CA SCE
  • View
    • Weakly Positive
  • View
    • Weakly Positive
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 4,4'-Sulfonyldianiline (80-08-0).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. 4,4'-Sulfonyldianiline (80-08-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-020 Bioassay of Dapsone for Possible Carcinogenicity (CASRN 80-08-0)
IMM90015 NTP Summary Reports on Immunotoxicology Vol. 1, No. 1-15: Immunotoxicological Evaluation of AIDS Therapeutics: Immunotoxicological Effects of Dapsone after 30 Days Oral Exposure In C57Bl/6 Mice - Repeat Study
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of 4,4'-Sulfonyldianiline (Dapsone) (80-08-0) in Male F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 4,4'-Sulfonyldianiline (Dapsone) (80-08-0) in Female F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 4,4'-Sulfonyldianiline (Dapsone) (80-08-0) in Male B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 4,4'-Sulfonyldianiline (Dapsone) (80-08-0) in Female B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 4,4'-Sulfonyldianiline (Dapsone) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 318705
Summary Data

Other NTP Studies

30-Day Immunotoxicity Evaluation (IMM90015) of 4,4'-Sulfonyldianiline (Dapsone) (80-08-0) in C57BL/6 Mice via Gavage
C57BL/6 Mice Individual and Summary Data

NTP Data Collections