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alpha-Pinene (80-56-8)

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to alpha-Pinene (80-56-8).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to alpha-Pinene (80-56-8).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. alpha-Pinene (80-56-8). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-606 NTP Technical Report on the Toxicology and Carcinogenesis Studies of α-Pinene (CASRN 80-56-8) Administered by Inhalation to Sprague Dawley (Hsd:Sprague Dawley SD) Rats, B6C3F1/N Mice, and CD-1 Mice
TOX-81 Toxicity Studies of α-Pinene (CAS No. 80-56-8) Administered by Inhalation to F344/N Rats and B6C3F1/N Mice
Toxicokinetic evaluation of the common indoor air pollutant, α-pinene, and its potential reactive metabolite, α-pinene oxide, following inhalation exposure in rodents Suramya Waidyanatha, Michael Hackett, Sherry R. Black, Timothy R. Fennell, Mathew D. Stout, Melanie R. Silinski, Scott L. Watson, Joseph Licause, Veronica G. Robinson, Barney Sparrow, Reshan A. Fernando, Stephen Cooper and Cynthia V. Rider

Toxicology and Applied Pharmacology, (2021) DOI: https://doi.org/10.1016/j.taap.2021.115496 PMID: 33744279 PMCID: PMC8336714

DOI: https://doi.org/10.22427/NTP-DATA-002-03031-0014-0000-4
The common indoor air pollutant α-pinene is metabolized to a genotoxic metabolite α-pinene oxide Suramya Waidyanatha, Sherry R. Black, Kristine L. Witt, Timothy R. Fennell, Carol Swartz, Leslie Recio, Scott L. Watson, Purvi R. Patel, Reshan A. Fernando, and Cynthia V. Rider

Taylor & Francis Online (2022) DOI: https://doi.org/10.1080/00498254.2022.2070047 PMID: 35473450
DOI: https://doi.org/10.22427/NTP-DATA-002-03031-0019-0000-9
Oral toxicokinetics of the indoor air pollutant, α-pinene, and its genotoxic metabolite, α-pinene oxide, in rodents and comparison to inhalation route of exposure Suramya Waidyanatha1*, Timothy R. Fennell2, Sherry R. Black2, Melanie R. Silinski2, Gabriel A. Knudsen2, Reshan A. Fernando2, and Cynthia V. Rider1

Affiliations
1Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
2RTI International, Research Triangle Park, NC, USA

*Corresponding Author
Suramya Waidyanatha,PhD.
Division of Translational Toxicology
National Institute of Environmental Health Sciences
111 TW Alexander Dr.

Toxicology and Applied Pharmacology, (2026) Vol 513 https://doi.org/10.1016/j.taap.2026.117893 PMID: 42217586

DOI: https://doi.org/10.22427/NTP-DATA-500-103-003-000-2

Study Data

Protocol

Toxicity and Carcinogenicity Studies

3-Month Evaluation of the Toxicity (C20302) of alpha-Pinene (80-56-8) in F344/N Rats via Nose-Only Respiratory Exposure
Study Tables
Individual Animal Data
3-Month Investigative Study of the Toxicity (C20302B) of alpha-Pinene (80-56-8) in Harlan Sprague Dawley Rats via Whole Body Respiratory Exposure
Study Tables
Individual Animal Data
3-Month Reproductive and Chronic Evaluation of the Toxicity (C20302B) of alpha-Pinene (80-56-8) in Harlan Sprague Dawley Rats via Whole Body Respiratory Exposure
Study Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C20302) of alpha-Pinene (80-56-8) in B6C3F1 Mice via Nose-Only Respiratory Exposure
Study Tables
Individual Animal Data
3-Month Reproductive Evaluation of the Toxicity (C20302B) of alpha-Pinene (80-56-8) in CD-1 Mice via Whole Body Respiratory Exposure
Study Tables
Individual Animal Data
3-Month and Chronic Evaluation of the Toxicity (C20302B) of alpha-Pinene (80-56-8) in B6C3F1 Mice via Whole Body Respiratory Exposure
Study Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of alpha-Pinene (80-56-8) in Micronucleus Study A82162 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of alpha-Pinene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A29697
Summary Data

Other NTP Studies

Toxicokinetic Evaluation (K03014) of Alpha pinene (DTXSID4026501) in Mouse and Rat
Individual Animal Data - Rats
Individual Animal Data - Mice
Blood and mammary gland toxicokinetics of α-pinene and α-pinene oxide

DTT Data Collections