alpha-Pinene (80-56-8)
Publications
TOX-81
Toxicity Studies of α-Pinene (CAS No. 80-56-8) Administered by Inhalation to F344/N Rats and B6C3F1/N Mice
Toxicokinetic evaluation of the common indoor air pollutant, α-pinene, and its potential reactive metabolite, α-pinene oxide, following inhalation exposure in rodents
Suramya Waidyanatha, Michael Hackett, Sherry R. Black, Timothy R. Fennell, Mathew D. Stout, Melanie R. Silinski, Scott L. Watson, Joseph Licause, Veronica G. Robinson, Barney Sparrow, Reshan A. Fernando, Stephen Cooper and Cynthia V. Rider
DOI: https://doi.org/10.22427/NTP-DATA-002-03031-0014-0000-4
DOI: https://doi.org/10.22427/NTP-DATA-002-03031-0014-0000-4
The common indoor air pollutant α-pinene is metabolized to a genotoxic metabolite α-pinene oxide
Suramya Waidyanatha, Sherry R. Black, Kristine L. Witt, Timothy R. Fennell, Carol Swartz, Leslie Recio, Scott L. Watson, Purvi R. Patel, Reshan A. Fernando, and Cynthia V. Rider
Taylor & Francis Online (2022) DOI: https://doi.org/10.1080/00498254.2022.2070047 PMID: 35473450
DOI: https://doi.org/10.22427/NTP-DATA-002-03031-0019-0000-9
Taylor & Francis Online (2022) DOI: https://doi.org/10.1080/00498254.2022.2070047 PMID: 35473450
DOI: https://doi.org/10.22427/NTP-DATA-002-03031-0019-0000-9
Study Data
Toxicity and Carcinogenicity Studies
3-Month Evaluation of the Toxicity (C20302) of alpha-Pinene (80-56-8) in F344/N Rats via Nose-Only Respiratory Exposure
Study Tables
- E03 - Growth Curves (214 kB)
- E04 - Mean Body Weights and Survival Table (57 kB)
- E05 - Clinical Observations Summary (49 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (159 kB)
- P04 - Neoplasms by Individual Animal (1 mB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (109 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (976 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (104 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (105 kB)
- P40 - Survival Curves (195 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (36 kB)
- Female Individual Animal Non Neoplastic Pathology Data (11 kB)
- Female Individual Animal Organ Weight Data (19 kB)
- Female Individual Animal Survival Data (11 kB)
- Male Individual Animal Body Weight Data (35 kB)
- Male Individual Animal Clinical Observations (5 kB)
- Male Individual Animal Non Neoplastic Pathology Data (61 kB)
- Male Individual Animal Organ Weight Data (19 kB)
- Male Individual Animal Survival Data (11 kB)
3-Month Evaluation of the Toxicity (C20302) of alpha-Pinene (80-56-8) in B6C3F1 Mice via Nose-Only Respiratory Exposure
Study Tables
- E03 - Growth Curves (204 kB)
- E04 - Mean Body Weights and Survival Table (181 kB)
- E05 - Clinical Observations Summary (67 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (82 kB)
- P04 - Neoplasms by Individual Animal (1 mB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (83 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (3 mB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (73 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (69 kB)
- P40 - Survival Curves (195 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (34 kB)
- Female Individual Animal Clinical Observations (3 kB)
- Female Individual Animal Neoplastic Pathology Data (2 kB)
- Female Individual Animal Non Neoplastic Pathology Data (12 kB)
- Female Individual Animal Organ Weight Data (19 kB)
- Female Individual Animal Survival Data (11 kB)
- Male Individual Animal Body Weight Data (34 kB)
- Male Individual Animal Clinical Observations (2 kB)
- Male Individual Animal Non Neoplastic Pathology Data (13 kB)
- Male Individual Animal Organ Weight Data (19 kB)
- Male Individual Animal Survival Data (11 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of alpha-Pinene (80-56-8) in Micronucleus Study A82162 in B6C3F1 Mice
Genetic Toxicity Evaluation of alpha-Pinene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A29697
Summary Data
- G06 - Ames Summary Data (134 KB)
Other NTP Studies
Toxicokinetic Evaluation (K03014) of Alpha pinene (DTXSID4026501) in Mouse and Rat
Individual Animal Data - Rats
- Body Weights and Calculated Dose (28 kB)
- Orginal Data- Pinene Mammary Tissue Data (95 kB)
- Original Data - Pinene Blood Data (55 kB)
- Original Data - Pinene Oxide Blood Data (108 kB)
- Original Data - Pinene Oxide Mammary Tissue Data (50 kB)
Individual Animal Data - Mice
- Body Weights and Calculated Dose (27 kB)
- Original Data - Pinene Blood Data (51 kB)
- Original Data - Pinene Mammary Tissue Data (54 kB)
- Original Data - Pinene Oxide Blood Data (49 kB)
- Original Data - Pinene Oxide Mammary Tissue Data (64 kB)
Blood and mammary gland toxicokinetics of α-pinene and α-pinene oxide
- Annotated Group Parameters - Rats & Mice (30 kB)
- Summary Data - Mice (1 mB)
- Summary Data - Rats (3 mB)