Dibutyl phthalate (84-74-2)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID2021781
Publications
TR-600
Toxicology and Carcinogenesis Studies of Di-n-butyl Phthalate Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice
TOX-30
Toxicity Studies of Dibutyl Phthalate (CASRN 84-74-2) Administered in Feed to F344/N Rats and B6C3F1Mice
Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT): Interlaboratory Study Dose Range Finding (DRF) data
DOI:
https://doi.org/10.22427/NTP-DATA-002-00102-0001-000-6
Study Data
Toxicity and Carcinogenicity Studies
3-Month Evaluation of the Toxicity (C93027A) of Peroxisome Project (Dibutyl Phthalate) (84-74-2) in Sprague-Dawley Rats Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C93027A) of Peroxisome Project (Dibutyl Phthalate) (84-74-2) in Sprague-Dawley Rats Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C93027A) of Peroxisome Project (Dibutyl Phthalate) (84-74-2) in B6C3F1 Mice Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C93027A) of Peroxisome Project (Dibutyl Phthalate) (84-74-2) in B6C3F1 Mice Exposed via Dosed Feed. NTP Special Study
2-Week Evaluation of the Toxicity (C93027A) of Peroxisome Project (Dibutyl Phthalate) (84-74-2) in Syrian Golden Hamsters Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C93027A) of Peroxisome Project (Dibutyl Phthalate) (84-74-2) in Syrian Golden Hamsters Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C93027A) of Peroxisome Project (Dibutyl Phthalate) (84-74-2) in Syrian Golden Hamsters Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C93027A) of Peroxisome Project (Dibutyl Phthalate) (84-74-2) in Harlan Sprague-Dawley Rats Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
Individual Animal Data
3-Month Evaluation of the Toxicity (C93027A) of Peroxisome Project (Dibutyl Phthalate) (84-74-2) in Harlan Sprague-Dawley Rats Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
3-Month Evaluation of the Toxicity (C93027A) of Peroxisome Project (Dibutyl Phthalate) (84-74-2) in Harlan Sprague-Dawley Rats Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C93027A) of Peroxisome Project (Dibutyl Phthalate) (84-74-2) in B6C3F1 Mice Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C93027A) of Peroxisome Project (Dibutyl Phthalate) (84-74-2) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
Individual Animal Data
3-Month Evaluation of the Toxicity (C93027A) of Peroxisome Project (Dibutyl Phthalate) (84-74-2) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
3-Month Evaluation of the Toxicity (C93027A) of Peroxisome Project (Dibutyl Phthalate) (84-74-2) in Syrian Golden Hamsters Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C93027A) of Peroxisome Project (Dibutyl Phthalate) (84-74-2) in Syrian Golden Hamsters Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
3-Month Evaluation of the Toxicity (C93027A) of Peroxisome Project (Dibutyl Phthalate) (84-74-2) in Syrian Golden Hamsters Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
Individual Animal Data
Evaluation of the Chronic (with Perinatal Exposure) Toxicity and Carcinogenicity (C10987) of Dibutyl Phthalate (84-74-2) in Harlan Sprague Dawley Rats Exposed via Dosed Feed
Chronic (with Perinatal Exposure) Study Tables
- E01 - Animal Removal Summary By Treatment Group (17 kB)
- E02 - Animals Removed from Experiment (165 kB)
- E03 - Growth Curves (65 kB)
- E04 - Mean Body Weights and Survival Table (20 kB)
- E05 - Clinical Observations Summary (33 kB)
- E08 - Feed Water and Compound Consumption Table (41 kB)
- Gestational Body Weights (22 kB)
- Gestational Food Consumption (18 kB)
- Gestational and Lactational Chemical Consumption (20 kB)
- Lactational Body Weights (22 kB)
- Lactational Food Consumption (19 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (66 kB)
- P04 - Neoplasms by Individual Animal (781 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (50 kB)
- P08 - Statistical Analysis of Primary Tumors (222 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (1 mB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (502 kB)
- P11 - Statistical Analysis of Survival Data (22 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (712 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (68 kB)
- P22 - Cause of Death Summary (17 kB)
- P40 - Survival Curves (481 kB)
- PA48 - Summary of Tissue Concentration.pdf (54 kB)
- PND 1 Litter Data (27 kB)
- PND 4 and 21 Live Litter Size and Survival (30 kB)
- Pup Body Weights (23 kB)
- R02 - Reproductive Performance Summary.pdf (40 kB)
Chronic (with Perinatal Exposure) Individual Animal Data
- Female Individual Animal Clinical Observations (262 kB)
- Female Individual Animal Neoplastic Pathology Data (133 kB)
- Female Individual Animal Non Neoplastic Pathology Data (832 kB)
- Female Individual Animal Survival Data (42 kB)
- Individual Animal DamID and PupID Data (22 kB)
- Individual Animal Reproductive Performance Data (21 kB)
- Individual Animal Tissue Concentration Data (9 kB)
- Male Individual Animal Clinical Observations (174 kB)
- Male Individual Animal Non Neoplastic Pathology Data (881 kB)
- Male Individual Animal Survival Data (41 kB)
- Male Individual Animal Terminal_Body Weight Data (71 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C10987) of Dibutyl Phthalate (84-74-2 ) in B6C3F1/N, Mouse Exposed Via Dosed Feed
Study Tables
- E01 - Animal Removal Summary By Treatment Group (12 kB)
- E02 - Animals Removed from Experiment (107 kB)
- E03 - Growth Curves (462 kB)
- E04 - Mean Body Weights and Survival Table (19 kB)
- E05 - Clinical Observations Summary (13 kB)
- E08 - Feed Water and Compound Consumption Table (25 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (58 kB)
- P04 - Neoplasms by Individual Animal (643 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (48 kB)
- P08 - Statistical Analysis of Primary Tumors (137 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (787 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (461 kB)
- P11 - Statistical Analysis of Survival Data (24 kB)
- P14 - Individual Animal Pathology Data (1 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (571 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (60 kB)
- P22 - Cause of Death Summary (15 kB)
- P40 - Survival Curves (430 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (309 kB)
- Female Individual Animal Clinical Observations (27 kB)
- Female Individual Animal Neoplastic Pathology Data (105 kB)
- Female Individual Animal Non Neoplastic Pathology Data (465 kB)
- Female Individual Animal Survival Data (34 kB)
- Female Individual Animal Terminal Body Weight Data (57 kB)
- Male Individual Animal Body Weight Data (335 kB)
- Male Individual Animal Neoplastic Pathology Data (95 kB)
- Male Individual Animal Non Neoplastic Pathology Data (501 kB)
- Male Individual Animal Terminal_Body Weight Data (57 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Peroxisome Project (Dibutyl Phthalate) (84-74-2) in Micronucleus Study A17278 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Peroxisome Project (Dibutyl Phthalate) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 077089
Summary Data
- G06 - Ames Summary Data (134 KB)
Other NTP Studies
ADME/TK Evaluation (S0045) of Dibutyl phthalate (84-74-2) in F344 Rats Exposed via Dermal Application
Toxicokinetic Evaluation (S0545) of dibutyl phthalate (DTXSID2021781) in Rat, Mouse and Hamster
Data
- Annotated Group Parameters (20 kB)
- Annotated Individual Animal Data (240 kB)
- Original Data (96 kB)
- Summary Data - Hamsters (558 kB)
- Summary Data - Mice (854 kB)
- Summary Data - Rats (948 kB)