COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:

2,4-Diaminotoluene (95-80-7)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4020402


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Positive, Male, Rats
View
  • Positive, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Negative, Male, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 2,4-Diaminotoluene (95-80-7).
Micronucleus - Mice
View
  • Male: Negative
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 2,4-Diaminotoluene (95-80-7).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 2,4-Diaminotoluene (95-80-7).
Bacterial Mutagenicity
View
  • Positive

Citation Information


NTP. 2,4-Diaminotoluene (95-80-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-162 Bioassay of 2,4-Diaminotoluene for Possible Carcinogenicity (CASRN 95-80-7)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of 2,4-Diaminotoluene (2,4-Toluene Diamine) (95-80-7) in Male F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,4-Diaminotoluene (2,4-Toluene Diamine) (95-80-7) in Female F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,4-Diaminotoluene (2,4-Toluene Diamine) (95-80-7) in Male B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,4-Diaminotoluene (2,4-Toluene Diamine) (95-80-7) in Female B6C3F1 Mice Exposed via Dosed Feed

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 2,4-Diaminotoluene (2,4-Toluene Diamine) (95-80-7) in Micronucleus Study 520516 in B6C3F1 Mice
Genetic Toxicity Evaluation of 2,4-Diaminotoluene (2,4-Toluene Diamine) (95-80-7) in Micronucleus Study 571690 in B6C3F1 Mice
Genetic Toxicity Evaluation of 2,4-Diaminotoluene (2,4-Toluene Diamine) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 707834
Summary Data

Other NTP Studies


14-Day Immunotoxicity Evaluation (IMM87034) of 2,4-Diaminotoluene (2,4-Toluene Diamine) (95-80-7) in B6C3F1 Mice via Gavage
2-Week Immunotoxicity Evaluation (IMM86001) of Toluenes (2-4-Diaminotoluene, p-Nitrotoluene, 4-Chloro-o-Phenylenediamine) (TOLUENES) in Female B6C3F1 Mice Exposed via Gavage