TOX-97: Toxicity Report Tables & Curves
Pathology Tables, Survival and Growth Curves from NTP
Short-Term Studies
On 05 April 2018 indirect bilirubin measurements were added to the clinical chemistry tables. No changes were made to existing data.
Pathology Working Group Approval Date: January 16, 2018.
On January 17, 2019 "Summary of Tissue Concentration (PA48)" tables were corrected: adjusted dose values are in millimolar concentrations, not molar
[July 28, 2022] Transcription errors were identified in the TOX-97 NTP report, and an audit was conducted. The report was revised and is republished with an appendix that identifies the corrections. Please note that the final data tables are available in the Chemical Effects in Biological Systems (CEBS) database.
DOI: http://doi.org/10.22427/NTP-OTHER-2
On January 17, 2019 "Summary of Tissue Concentration (PA48)" tables were corrected: adjusted dose values are in millimolar concentrations, not molar
[July 28, 2022] Transcription errors were identified in the TOX-97 NTP report, and an audit was conducted. The report was revised and is republished with an appendix that identifies the corrections. Please note that the final data tables are available in the Chemical Effects in Biological Systems (CEBS) database.
DOI: http://doi.org/10.22427/NTP-OTHER-2
TOX-97: Perfluorinated Compounds: Carboxylates
Short-Term
28-Day PFHXA (Perfluorohexanoic acid) Study Tables
- E01 - Animal Removal Summary By Treatment Group (12 KB)
- E02 - Animals Removed from Experiment (65 KB)
- E03 - Growth Curves (382 KB)
- E04 - Mean Body Weights and Survival Table (16 KB)
- E05 - Clinical Observations Summary (18 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (31 KB)
- P04 - Neoplasms by Individual Animal (212 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (33 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (231 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (132 KB)
- P11 - Statistical Analysis of Survival Data (27 KB)
- P14 - Individual Animal Pathology Data (273 KB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (213 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (32 KB)
- P40 - Survival Curves (383 KB)
- PA06 - Organ Weights Summary (115 KB)
- PA41 - Clinical Chemistry Summary (301 KB)
- PA43 - Hematology Summary (270 KB)
- PA45 - Liver Special Studies Summary (35 KB)
- PA48 - Summary of Tissue Concentration (71 KB)
- R06 - Andrology Summary (49 KB)
- R07 - Hormone Summary (66 KB)
- Results of Vaginal Cytology Study Using Transition Matrix Approach (43 KB)
- Summary of Estrous Stages and Cycle Data (53 KB)
- Vaginal Cytology Plot (17 KB)
28-Day PFHXA (Perfluorohexanoic acid) Individual Animal Data
- Female Individual Animal Body Weight Data (18 KB)
- Female Individual Animal Non Neoplastic Pathology Data (43 KB)
- Female Individual Animal Survival Data (11 KB)
- Female Individual Animal Terminal Body Weight Data (18 KB)
- Female Individual Clinical Observations (2 KB)
- Individual Animal Andrology Data (7 KB)
- Individual Animal Clinical Chemistry Data (15 KB)
- Individual Animal Hematology Data (18 KB)
- Individual Animal Hormone Data (11 KB)
- Individual Animal Liver Special Studies Data (6 KB)
- Individual Animal Organ Weight Data (14 KB)
- Individual Animal Tissue Concentration Data (10 KB)
- Individual Vaginal Cytology Data (23 KB)
- Individual_Animal_PCR_Data (24 KB)
- Male Individual Animal Body Weight Data (17 KB)
- Male Individual Animal Neoplastic Pathology Data (2 KB)
- Male Individual Animal Non Neoplastic Pathology Data (49 KB)
- Male Individual Animal Survival Data (11 KB)
- Male Individual Clinical Observations (3 KB)
28-Day PFOA (Perfluorooctanoic Acid) Study Tables
- E01 - Animal Removal Summary By Treatment Group (12 KB)
- E02 - Animals Removed from Experiment (65 KB)
- E03 - Growth Curves (356 KB)
- E04 - Mean Body Weights and Survival Table (16 KB)
- E05 - Clinical Observations Summary (18 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (35 KB)
- P04 - Neoplasms by Individual Animal (212 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (33 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (244 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (179 KB)
- P11 - Statistical Analysis of Survival Data (27 KB)
- P14 - Individual Animal Pathology Data (275 KB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (215 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (34 KB)
- P40 - Survival Curves (393 KB)
- PA06 - Organ Weights Summary Females (69 KB)
- PA06 - Organ Weights Summary Males (69 KB)
- PA41 - Clinical Chemistry Summary Females (160 KB)
- PA41 - Clinical Chemistry Summary Males (160 KB)
- PA43 - Hematology Summary Females (144 KB)
- PA43 - Hematology Summary Males (144 KB)
- PA45 - Liver Special Studies Summary (35 KB)
- PA48 - Summary of Tissue Concentration Females (41 KB)
- PA48 - Summary of Tissue Concentration Males (53 KB)
- R06 - Andrology Summary (49 KB)
- R07 - Hormone Summary Females (45 KB)
- R07 - Hormone Summary Males (45 KB)
- Results of Vaginal Cytology Study Using Transition Matrix Approach (48 KB)
- Summary of Estrous Stages and Cycle Data (58 KB)
- Vaginal Cytology Plot (17 KB)
28-Day PFOA (Perfluorooctanoic Acid) Individual Animal Data
- Female Individual Animal Body Weight Data (18 KB)
- Female Individual Animal Non Neoplastic Pathology Data (54 KB)
- Female Individual Animal Survival Data (11 KB)
- Female Individual Animal Terminal Body Weight Data (18 KB)
- Female Individual Clinical Observations (3 KB)
- Individual Animal Andrology Data (7 KB)
- Individual Animal Clinical Chemistry Data Females (10 KB)
- Individual Animal Clinical Chemistry Data Males (10 KB)
- Individual Animal Hematology Data Females (11 KB)
- Individual Animal Hematology Data Males (11 KB)
- Individual Animal Hormone Data Females (7 KB)
- Individual Animal Hormone Data Males (7 KB)
- Individual Animal Liver Special Studies Data (6 KB)
- Individual Animal Organ Weight Data Females (9 KB)
- Individual Animal Organ Weight Data Males (9 KB)
- Individual Animal PCR Data (24 KB)
- Individual Animal Tissue Concentration Data Females (7 KB)
- Individual Animal Tissue Concentration Data Males (7 KB)
- Individual Vaginal Cytology Data (23 KB)
- Male Individual Animal Body Weight Data (18 KB)
- Male Individual Animal Non Neoplastic Pathology Data (62 KB)
- Male Individual Animal Survival Data (11 KB)
- Male Individual Animal Terminal Body Weight Data (18 KB)
- Male Individual Clinical Observations (3 KB)
28-Day PFNA (Perfluorononanoic Acid) Study Tables
- E01 - Animal Removal Summary By Treatment Group (17 KB)
- E02 - Animals Removed from Experiment (65 KB)
- E03 - Growth Curves (366 KB)
- E04 - Mean Body Weights and Survival Table (16 KB)
- E05 - Clinical Observations Summary (18 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (34 KB)
- P04 - Neoplasms by Individual Animal (271 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (33 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (294 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (162 KB)
- P11 - Statistical Analysis of Survival Data (27 KB)
- P14 - Individual Animal Pathology Data (304 KB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (270 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (35 KB)
- P40 - Survival Curves (408 KB)
- PA06 - Organ Weights Summary Females (63 KB)
- PA06 - Organ Weights Summary Males (63 KB)
- PA41 - Clinical Chemistry Summary Females (126 KB)
- PA41 - Clinical Chemistry Summary Males (126 KB)
- PA43 - Hematology Summary Females (101 KB)
- PA43 - Hematology Summary Males (131 KB)
- PA45 - Liver Special Studies Summary (30 KB)
- PA48 - Summary of Tissue Concentration Females (39 KB)
- PA48 - Summary of Tissue Concentration Males (50 KB)
- R06 - Andrology Summary (49 KB)
- R07 - Hormone Summary Females (38 KB)
- R07 - Hormone Summary Males (38 KB)
- Results of Vaginal Cytology Study Using Transition Matrix Approach (45 KB)
- Summary of Estrous Stages and Cycle Data (53 KB)
- Vaginal Cytology Plot (17 KB)
28-Day PFNA (Perfluorononanoic Acid) Individual Animal Data
- Female Individual Animal Body Weight Data (17 KB)
- Female Individual Animal Non Neoplastic Pathology Data (68 KB)
- Female Individual Animal Survival Data (11 KB)
- Female Individual Animal Terminal Body Weight Data (18 KB)
- Female Individual Clinical Observations (8 KB)
- Individual Animal Andrology Data (7 KB)
- Individual Animal Clinical Chemistry Data Females (10 KB)
- Individual Animal Clinical Chemistry Data Males (10 KB)
- Individual Animal Hematology Data Females (11 KB)
- Individual Animal Hematology Data Males (11 KB)
- Individual Animal Hormone Data Females (7 KB)
- Individual Animal Hormone Data Males (7 KB)
- Individual Animal Liver Special Studies Data (6 KB)
- Individual Animal Organ Weight Data Females (8 KB)
- Individual Animal Organ Weight Data Males (8 KB)
- Individual Animal Tissue Concentration Data Females (7 KB)
- Individual Animal Tissue Concentration Data Males (7 KB)
- Individual Vaginal Cytology Data (23 KB)
- Individual_Animal_PCR_Data (20 KB)
- Male Individual Animal Body Weight Data (17 KB)
- Male Individual Animal Non Neoplastic Pathology Data (145 KB)
- Male Individual Animal Organ Weight Data (18 KB)
- Male Individual Animal Survival Data (11 KB)
- Male Individual Clinical Observations (10 KB)
28-Day PFDA (Perfluorodecanoic Acid) Study Tables
- E01 - Animal Removal Summary By Treatment Group (12 KB)
- E02 - Animals Removed from Experiment (65 KB)
- E03 - Growth Curves (362 KB)
- E04 - Mean Body Weights and Survival Table (16 KB)
- E05 - Clinical Observations Summary (14 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (33 KB)
- P04 - Neoplasms by Individual Animal (219 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (35 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (232 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (150 KB)
- P11 - Statistical Analysis of Survival Data (27 KB)
- P14 - Individual Animal Pathology Data (276 KB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (219 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (34 KB)
- P40 - Survival Curves (408 KB)
- PA06 - Organ Weights Summary (115 KB)
- PA41 - Clinical Chemistry Summary (300 KB)
- PA43 - Hematology Summary (270 KB)
- PA45 - Liver Special Studies Summary (35 KB)
- PA48 - Summary of Tissue Concentration (71 KB)
- R06 - Andrology Summary (49 KB)
- R07 - Hormone Summary (67 KB)
- Results of Vaginal Cytology Study Using Transition Matrix Approach (41 KB)
- Summary of Estrous Stages and Cycle Data (58 KB)
- Vaginal Cytology Plot (17 KB)
28-Day PFDA (Perfluorodecanoic Acid) Individual Animal Data
- Female Individual Animal Body Weight Data (18 KB)
- Female Individual Animal Non Neoplastic Pathology Data (44 KB)
- Female Individual Animal Survival Data (11 KB)
- Female Individual Animal Terminal Body Weight Data (18 KB)
- Female Individual Clinical Observations (2 KB)
- Individual Animal Andrology Data (7 KB)
- Individual Animal Clinical Chemistry Data (16 KB)
- Individual Animal Hematology Data (17 KB)
- Individual Animal Hormone Data (11 KB)
- Individual Animal Liver Special Studies Data (6 KB)
- Individual Animal Organ Weight Data (15 KB)
- Individual Animal Tissue Concentration Data (10 KB)
- Individual Vaginal Cytology Data (23 KB)
- Individual_Animal_PCR_Data (24 KB)
- Male Individual Animal Body Weight Data (18 KB)
- Male Individual Animal Non Neoplastic Pathology Data (73 KB)
- Male Individual Animal Survival Data (11 KB)
- Male Individual Animal Terminal Body Weight Data (18 KB)
- Male Individual Clinical Observations (4 KB)
28-Day Wyeth 14,643 (WY) Study Tables
- E01 - Animal Removal Summary By Treatment Group (12 KB)
- E02 - Animals Removed from Experiment (46 KB)
- E03 - Growth Curves (338 KB)
- E04 - Mean Body Weights and Survival Table (15 KB)
- E05 - Clinical Observations Summary (12 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (33 KB)
- P04 - Neoplasms by Individual Animal (162 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (32 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (167 KB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (131 KB)
- P11 - Statistical Analysis of Survival Data (22 KB)
- P14 - Individual Animal Pathology Data (191 KB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (162 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (33 KB)
- P40 - Survival Curves (378 KB)
- PA06 - Organ Weights Summary (93 KB)
- PA41 - Clinical Chemistry Summary (201 KB)
- PA43 - Hematology Summary (180 KB)
- PA45 - Liver Special Studies Summary (29 KB)
- R06 - Andrology Summary (49 KB)
- R07 - Hormone Summary (49 KB)
- Results of Vaginal Cytology Study Using Transition Matrix Approach (42 KB)
- Summary of Estrous Stages and Cycle Data (53 KB)
- Vaginal Cytology Plot (17 KB)
28-Day Wyeth 14,643 (WY) Individual Animal Data
- Female Individual Animal Body Weight Data (12 KB)
- Female Individual Animal Non Neoplastic Pathology Data (24 KB)
- Female Individual Animal Survival Data (8 KB)
- Female Individual Animal Terminal Body Weight Data (13 KB)
- Individual Animal Andrology Data (7 KB)
- Individual Animal Clinical Chemistry Data (12 KB)
- Individual Animal Hematology Data (14 KB)
- Individual Animal Hormone Data (9 KB)
- Individual Animal Liver Special Studies Data (5 KB)
- Individual Animal Organ Weight Data (11 KB)
- Individual Vaginal Cytology Data (23 KB)
- Individual_Animal_PCR_Data (20 KB)
- Male Individual Animal Body Weight Data (12 KB)
- Male Individual Animal Non Neoplastic Pathology Data (33 KB)
- Male Individual Animal Survival Data (8 KB)
- Male Individual Animal Terminal Body Weight Data (13 KB)
- Male Individual Clinical Observations (2 KB)