TOX-97: Perfluorohexanoic acid (307-24-4), Perfluorooctanoic acid (335-67-1), Perfluorononanoic acid (375-95-1), Perfluorodecanoic acid (335-76-2), WY-14643 (50892-23-4)
DOI: http://doi.org/10.22427/NTP-OTHER-2
Study Results
Genetic Toxicology
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Citation Information
NTP. TOX-97: Perfluorohexanoic acid (307-24-4), Perfluorooctanoic acid (335-67-1), Perfluorononanoic acid (375-95-1), Perfluorodecanoic acid (335-76-2), WY-14643 (50892-23-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).
Publications
TOX-97
NTP Report on the Toxicity Studies of Perfluorinated Compounds: Carboxylates Administered via Oral Gavage in Hsd: Sprague Dawley SD Rats
Study Data
Toxicity and Carcinogenicity Studies
28-Day Evaluation of the Toxicity (C04049) of Perfluorononanoic Acid (PFNA) (375-95-1) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
- E01 - Animal Removal Summary By Treatment Group (17 kB)
- E02 - Animals Removed from Experiment (67 kB)
- E03 - Growth Curves (375 kB)
- E04 - Mean Body Weights and Survival Table (16 kB)
- E05 - Clinical Observations Summary (18 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (34 kB)
- P04 - Neoplasms by Individual Animal (278 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (301 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (166 kB)
- P11 - Statistical Analysis of Survival Data (28 kB)
- P14 - Individual Animal Pathology Data (311 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (277 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (36 kB)
- P40 - Survival Curves (418 kB)
- PA06 - Organ Weights Summary Females (65 kB)
- PA06 - Organ Weights Summary Males (65 kB)
- PA41 - Clinical Chemistry Summary Females (129 kB)
- PA41 - Clinical Chemistry Summary Males (129 kB)
- PA43 - Hematology Summary Females (103 kB)
- PA43 - Hematology Summary Males (135 kB)
- PA45 - Liver Special Studies Summary (31 kB)
- PA48 - Summary of Tissue Concentration Males (52 kB)
- PA48 - Summary of Tissue Concentration Females (40 kB)
- R06 - Andrology Summary (50 kB)
- R07 - Hormone Summary Females (38 kB)
- R07 - Hormone Summary Males (38 kB)
- Results of Vaginal Cytology Study Using Transition Matrix Approach (47 kB)
- Summary of Estrous Stages and Cycle Data (54 kB)
- Vaginal Cytology Plot (17 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (18 kB)
- Female Individual Animal Non Neoplastic Pathology Data (70 kB)
- Female Individual Animal Survival Data (11 kB)
- Female Individual Animal Terminal Body Weight Data (19 kB)
- Female Individual Clinical Observations (8 kB)
- Individual Animal Andrology Data (7 kB)
- Individual Animal Clinical Chemistry Data Females (10 kB)
- Individual Animal Clinical Chemistry Data Males (10 kB)
- Individual Animal Hematology Data Females (11 kB)
- Individual Animal Hematology Data Males (11 kB)
- Individual Animal Hormone Data Females (7 kB)
- Individual Animal Hormone Data Males (7 kB)
- Individual Animal Liver Special Studies Data (6 kB)
- Individual Animal Organ Weight Data Females (8 kB)
- Individual Animal Organ Weight Data Males (8 kB)
- Individual Animal Tissue Concentration Data Females (7 kB)
- Individual Animal Tissue Concentration Data Males (7 kB)
- Individual Vaginal Cytology Data (23 kB)
- Individual_Animal_PCR_Data (20 kB)
- Male Individual Animal Body Weight Data (18 kB)
- Male Individual Animal Non Neoplastic Pathology Data (148 kB)
- Male Individual Animal Survival Data (11 kB)
- Male Individual Animal Terminal Body Weight Data (19 kB)
- Male Individual Clinical Observations (11 kB)
28-Day Evaluation of the Toxicity (C20613) of Perfluorohexanoic acid (PFHXA) (307-24-4) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
- E01 - Animal Removal Summary By Treatment Group (12 kB)
- E02 - Animals Removed from Experiment (67 kB)
- E03 - Growth Curves (391 kB)
- E04 - Mean Body Weights and Survival Table (16 kB)
- E05 - Clinical Observations Summary (18 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (32 kB)
- P04 - Neoplasms by Individual Animal (217 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (237 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (136 kB)
- P11 - Statistical Analysis of Survival Data (27 kB)
- P14 - Individual Animal Pathology Data (280 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (218 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (33 kB)
- P40 - Survival Curves (393 kB)
- PA06 - Organ Weights Summary (117 kB)
- PA41 - Clinical Chemistry Summary (308 kB)
- PA43 - Hematology Summary (276 kB)
- PA45 - Liver Special Studies Summary (36 kB)
- PA48 - Summary of Tissue Concentration (72 kB)
- R06 - Andrology Summary (50 kB)
- R07 - Hormone Summary (68 kB)
- Results of Vaginal Cytology Study Using Transition Matrix Approach (44 kB)
- Summary of Estrous Stages and Cycle Data (54 kB)
- Vaginal Cytology Plot (17 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (18 kB)
- Female Individual Animal Non Neoplastic Pathology Data (44 kB)
- Female Individual Animal Survival Data (11 kB)
- Female Individual Animal Terminal Body Weight Data (19 kB)
- Female Individual Clinical Observations (2 kB)
- Individual Animal Andrology Data (7 kB)
- Individual Animal Clinical Chemistry Data (16 kB)
- Individual Animal Hematology Data (18 kB)
- Individual Animal Hormone Data (11 kB)
- Individual Animal Liver Special Studies Data (6 kB)
- Individual Animal Organ Weight Data (15 kB)
- Individual Animal Tissue Concentration Data (10 kB)
- Individual Vaginal Cytology Data (24 kB)
- Individual_Animal_PCR_Data (25 kB)
- Male Individual Animal Body Weight Data (18 kB)
- Male Individual Animal Neoplastic Pathology Data (2 kB)
- Male Individual Animal Non Neoplastic Pathology Data (50 kB)
- Male Individual Animal Survival Data (11 kB)
- Male Individual Clinical Observations (3 kB)
28-Day Evaluation of the Toxicity (C20615) of Perfluorodecanoic Acid (PFDA) (335-76-2) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
- E01 - Animal Removal Summary By Treatment Group (12 kB)
- E02 - Animals Removed from Experiment (67 kB)
- E03 - Growth Curves (371 kB)
- E04 - Mean Body Weights and Survival Table (16 kB)
- E05 - Clinical Observations Summary (14 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (34 kB)
- P04 - Neoplasms by Individual Animal (225 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (35 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (238 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (154 kB)
- P11 - Statistical Analysis of Survival Data (27 kB)
- P14 - Individual Animal Pathology Data (282 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (224 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (35 kB)
- P40 - Survival Curves (417 kB)
- PA06 - Organ Weights Summary (118 kB)
- PA41 - Clinical Chemistry Summary (307 kB)
- PA43 - Hematology Summary (276 kB)
- PA45 - Liver Special Studies Summary (36 kB)
- PA48 - Summary of Tissue Concentration (73 kB)
- R06 - Andrology Summary (50 kB)
- R07 - Hormone Summary (68 kB)
- Results of Vaginal Cytology Study Using Transition Matrix Approach (42 kB)
- Summary of Estrous Stages and Cycle Data (59 kB)
- Vaginal Cytology Plot (17 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (18 kB)
- Female Individual Animal Non Neoplastic Pathology Data (46 kB)
- Female Individual Animal Survival Data (11 kB)
- Female Individual Animal Terminal Body Weight Data (19 kB)
- Female Individual Clinical Observations (2 kB)
- Individual Animal Andrology Data (7 kB)
- Individual Animal Clinical Chemistry Data (16 kB)
- Individual Animal Hematology Data (18 kB)
- Individual Animal Hormone Data (12 kB)
- Individual Animal Liver Special Studies Data (6 kB)
- Individual Animal Organ Weight Data (15 kB)
- Individual Animal Tissue Concentration Data (10 kB)
- Individual Vaginal Cytology Data (23 kB)
- Individual_Animal_PCR_Data (24 kB)
- Male Individual Animal Body Weight Data (18 kB)
- Male Individual Animal Non Neoplastic Pathology Data (74 kB)
- Male Individual Animal Survival Data (11 kB)
- Male Individual Animal Terminal Body Weight Data (19 kB)
- Male Individual Clinical Observations (4 kB)
28-Day Evaluation of the Toxicity (C91069) of Wyeth 14,643 (WY) (50892-23-4) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
- E01 - Animal Removal Summary By Treatment Group (12 kB)
- E02 - Animals Removed from Experiment (47 kB)
- E03 - Growth Curves (346 kB)
- E04 - Mean Body Weights and Survival Table (15 kB)
- E05 - Clinical Observations Summary (12 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (34 kB)
- P04 - Neoplasms by Individual Animal (165 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (33 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (171 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (134 kB)
- P11 - Statistical Analysis of Survival Data (23 kB)
- P14 - Individual Animal Pathology Data (196 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (166 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (33 kB)
- P40 - Survival Curves (387 kB)
- PA06 - Organ Weights Summary (95 kB)
- PA41 - Clinical Chemistry Summary (206 kB)
- PA43 - Hematology Summary (185 kB)
- PA45 - Liver Special Studies Summary (30 kB)
- R06 - Andrology Summary (50 kB)
- R07 - Hormone Summary (50 kB)
- Results of Vaginal Cytology Study Using Transition Matrix Approach (43 kB)
- Summary of Estrous Stages and Cycle Data (54 kB)
- Vaginal Cytology Plot (17 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (13 kB)
- Female Individual Animal Non Neoplastic Pathology Data (25 kB)
- Female Individual Animal Survival Data (8 kB)
- Female Individual Animal Terminal Body Weight Data (13 kB)
- Individual Animal Andrology Data (7 kB)
- Individual Animal Clinical Chemistry Data (12 kB)
- Individual Animal Hematology Data (14 kB)
- Individual Animal Hormone Data (9 kB)
- Individual Animal Liver Special Studies Data (5 kB)
- Individual Animal Organ Weight Data (12 kB)
- Individual Vaginal Cytology Data (24 kB)
- Individual_Animal_PCR_Data (20 kB)
- Male Individual Animal Body Weight Data (13 kB)
- Male Individual Animal Non Neoplastic Pathology Data (33 kB)
- Male Individual Animal Survival Data (8 kB)
- Male Individual Animal Terminal Body Weight Data (13 kB)
- Male Individual Clinical Observations (2 kB)
28-Day Evaluation of the Toxicity (C91070B) of Perfluorooctanoic Acid (PFOA) (335-67-1) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
- E01 - Animal Removal Summary By Treatment Group (12 kB)
- E02 - Animals Removed from Experiment (67 kB)
- E03 - Growth Curves (365 kB)
- E04 - Mean Body Weights and Survival Table (16 kB)
- E05 - Clinical Observations Summary (18 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (36 kB)
- P04 - Neoplasms by Individual Animal (218 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (250 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (184 kB)
- P11 - Statistical Analysis of Survival Data (27 kB)
- P14 - Individual Animal Pathology Data (282 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (220 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (35 kB)
- P40 - Survival Curves (402 kB)
- PA06 - Organ Weights Summary Females (70 kB)
- PA06 - Organ Weights Summary Males (71 kB)
- PA41 - Clinical Chemistry Summary Females (164 kB)
- PA41 - Clinical Chemistry Summary Males (164 kB)
- PA43 - Hematology Summary Females (148 kB)
- PA43 - Hematology Summary Males (148 kB)
- PA45 - Liver Special Studies Summary Males (36 kB)
- PA48 - Summary of Tissue Concentration Males (54 kB)
- PA48 - Summary of Tissue Concentration Females (42 kB)
- R06 - Andrology Summary (50 kB)
- R07 - Hormone Summary Females (46 kB)
- R07 - Hormone Summary Males (46 kB)
- Results of Vaginal Cytology Study Using Transition Matrix Approach (49 kB)
- Summary of Estrous Stages and Cycle Data (59 kB)
- Vaginal Cytology Plot (17 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (18 kB)
- Female Individual Animal Non Neoplastic Pathology Data (55 kB)
- Female Individual Animal Survival Data (11 kB)
- Female Individual Animal Terminal Body Weight Data (19 kB)
- Female Individual Clinical Observations (3 kB)
- Individual Animal Andrology Data (7 kB)
- Individual Animal Clinical Chemistry Data Females (10 kB)
- Individual Animal Clinical Chemistry Data Males (11 kB)
- Individual Animal Hematology Data Females (12 kB)
- Individual Animal Hematology Data Males (12 kB)
- Individual Animal Hormone Data Females (8 kB)
- Individual Animal Hormone Data Males (8 kB)
- Individual Animal Liver Special Studies Data (6 kB)
- Individual Animal Organ Weight Data Females (9 kB)
- Individual Animal Organ Weight Data Males (9 kB)
- Individual Animal PCR Data (25 kB)
- Individual Animal Tissue Concentration Data Females (7 kB)
- Individual Animal Tissue Concentration Data Males (7 kB)
- Individual Vaginal Cytology Data (24 kB)
- Male Individual Animal Body Weight Data (18 kB)
- Male Individual Animal Non Neoplastic Pathology Data (63 kB)
- Male Individual Animal Survival Data (11 kB)
- Male Individual Animal Terminal Body Weight Data (19 kB)
- Male Individual Clinical Observations (3 kB)