TR-601: Technical Report Pathology Tables and Curves
Pathology Tables, Survival and Growth Curves from NTP
Long Term, Genetic Toxicology, Bench Mark Dose Analyses of Neoplastic Lesions Studies
P03 - Reports show the bilateral incidence (“bilateral” descriptor) and the unilateral incidence (no descriptor) for paired organs and does not show the combined unilateral/bilateral incidence
P09 - Reports show the bilateral incidence (“bilateral” descriptor) and the unilateral incidence (no descriptor) for paired organs and does not show the combined unilateral/bilateral incidence
P10 - Report only analyzes the bilateral incidence (“bilateral” descriptor) and the combined unilateral/bilateral incidence (no descriptor) for paired organs and does not show the unilateral incidence
P18 - Reports show the bilateral incidence (“bilateral” descriptor) and the unilateral incidence (no descriptor) for paired organs and does not show the combined unilateral/bilateral incidence
Genetox data added on 30-September-2020
BMD Male Pancreas file updated on November 10, 2020 to include highest exposure group in the analysis for perinatal chronic study.
PND 4 Live Litter Size and Survival table was updated on March 31,2021.
DOI: https://doi.org/10.22427/NTP-DATA-TR-601
P09 - Reports show the bilateral incidence (“bilateral” descriptor) and the unilateral incidence (no descriptor) for paired organs and does not show the combined unilateral/bilateral incidence
P10 - Report only analyzes the bilateral incidence (“bilateral” descriptor) and the combined unilateral/bilateral incidence (no descriptor) for paired organs and does not show the unilateral incidence
P18 - Reports show the bilateral incidence (“bilateral” descriptor) and the unilateral incidence (no descriptor) for paired organs and does not show the combined unilateral/bilateral incidence
Genetox data added on 30-September-2020
BMD Male Pancreas file updated on November 10, 2020 to include highest exposure group in the analysis for perinatal chronic study.
PND 4 Live Litter Size and Survival table was updated on March 31,2021.
DOI: https://doi.org/10.22427/NTP-DATA-TR-601
TR-601: Di(2-ethylhexyl) Phthalate
Long Term
Chronic with Perinatal Study Tables - Rats
- E01 - Animal Removal Summary By Treatment Group (12 KB)
- E02 - Animals Removed from Experiment (168 KB)
- E03 - Growth Curves - Litter Based (66 KB)
- E04 - Mean Body Weights and Survival Table - Litter Based (20 KB)
- E05 - Clinical Observations Summary (32 KB)
- E08 - Feed Water and Compound Consumption Table (41 KB)
- Gestational and Lactational Chemical Consumption (19 KB)
- Gestational Body Weights (22 KB)
- Gestational Food Consumption (17 KB)
- Lactational Body Weights (20 KB)
- Lactational Food Consumption (18 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (72 KB)
- P04 - Neoplasms by Individual Animal (797 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (55 KB)
- P08 - Statistical Analysis of Primary Tumors (274 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (1 MB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Litter based (608 KB)
- P11 - Statistical Analysis of Survival Data (28 KB)
- P14 - Individual Animal Pathology Data (2 MB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (738 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (75 KB)
- P22 - Cause of Death Summary (19 KB)
- P40 - Survival Curves (483 KB)
- PA46Rs - Summary of Gross Pathology with Litter Incidence (319 KB)
- PA48 - Summary of Tissue Concentration (37 KB)
- PND 1 Litter Data (24 KB)
- PND 4 Live Litter Size and Survival (113 KB)
- Pup Body Weights (22 KB)
- R02 - Reproductive Performance Summary (40 KB)
- R23 - Gubernaculum Length Summary (55 KB)
Chronic with Perinatal Individual Animal Data - Rats
- Female Individual Animal Body Weight Data All Animals (501 KB)
- Female Individual Animal Body Weight Data All Animals- Gestation (63 KB)
- Female Individual Animal Body Weight Data All Animals - Lactation (37 KB)
- Female Individual Animal Clinical Observations (246 KB)
- Female Individual Animal Neoplastic Pathology Data (134 KB)
- Female Individual Animal Non Neoplastic Pathology Data (1 MB)
- Female Individual Animal Survival Data (41 KB)
- Female Individual Animal Survival Data - Gestation (36 KB)
- Female Individual Animal Survival Data - Lactation (23 KB)
- Female Individual Animal Terminal Body Weight Data (70 KB)
- Female Individual Animal Terminal Body Weight Data - Gestation (62 KB)
- Female Individual Animal Terminal Body Weight Data - Lactation (42 KB)
- Individual Animal Clinical Observations Data (9 KB)
- Individual Animal DamID and PupID Data (22 KB)
- Individual Animal Reproductive Performance Data (13 KB)
- Individual Animal Tissue Concentration Data (7 KB)
- Individual Pup Census and Litter Weight by Sex Data (26 KB)
- Male Individual Animal Body Weight Data All Animals (499 KB)
- Male Individual Animal Clinical Observations (190 KB)
- Male Individual Animal Neoplastic Pathology Data (142 KB)
- Male Individual Animal Non Neoplastic Pathology Data (1 MB)
- Male Individual Animal Survival Data (40 KB)
- Male Individual Animal Terminal Body Weight Data (69 KB)
- Urogenital Observation Data and Summaries (343 KB)
Chronic Study Tables - Rats
- E01 - Animal Removal Summary By Treatment Group (12 KB)
- E02 - Animals Removed from Experiment (148 KB)
- E03 - Growth Curves (480 KB)
- E04 - Mean Body Weights and Survival Table (20 KB)
- E05 - Clinical Observations Summary (31 KB)
- E08 - Feed Water and Compound Consumption Table (41 KB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (74 KB)
- P04 - Neoplasms by Individual Animal (850 KB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (53 KB)
- P08 - Statistical Analysis of Primary Tumors (237 KB)
- P09 - Non-Neoplastic Lesions by Individual Animal (1 MB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (478 KB)
- P11 - Statistical Analysis of Survival Data (28 KB)
- P14 - Individual Animal Pathology Data (2 MB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (736 KB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (76 KB)
- P22 - Cause of Death Summary (17 KB)
- P40 - Survival Curves (491 KB)
Chronic Individual Animal Data - Rats
- Female Individual Animal Body Weight Data All Animals (480 KB)
- Female Individual Animal Clinical Observations (229 KB)
- Female Individual Animal Neoplastic Pathology Data (163 KB)
- Female Individual Animal Non Neoplastic Pathology Data (1 MB)
- Female Individual Animal Survival Data (41 KB)
- Female Individual Animal Terminal Body Weight Data (70 KB)
- Male Individual Animal Body Weight Data All Animals (474 KB)
- Male Individual Animal Clinical Observations (144 KB)
- Male Individual Animal Neoplastic Pathology Data (146 KB)
- Male Individual Animal Non Neoplastic Pathology Data (1 MB)
- Male Individual Animal Survival Data (40 KB)
- Male Individual Animal Terminal Body Weight Data (69 KB)
Genetic Toxicology
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate (117-81-7) in Micronucleus Study A04384 in Tg.AC (FVB/N) Mice
- A04384 G04 In Vivo Micronucleus Summary Data (65 KB)
- A04384 Individual Animal In Vivo Micronucleus Data (11 KB)
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate (117-81-7) in Micronucleus Study A15851 in Tg.AC (FVB/N) Mice
- A15851 G04 In Vivo Micronucleus Summary Data (65 KB)
- A15851 Individual Animal In Vivo Micronucleus Data (11 KB)
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate (117-81-7) in Micronucleus Study A15927 in B6C3F1 Mice
- A15927 G04 In Vivo Micronucleus Summary Data (60 KB)
- A15927 Individual Animal In Vivo Micronucleus Data (10 KB)
Bench Mark Dose Analyses of Neoplastic Lesions
Results Summary
- Summary of BMD Results (10 KB)
BMD Analyses, Chronic with Perinatal Study-Rats
- Perinatal Female Liver BMD analysis (366 KB)
- Perinatal Female Pancreas BMD analysis (361 KB)
- Perinatal Female Uterus BMD analysis (365 KB)
- Perinatal Male Liver BMD analysis (364 KB)
- Perinatal Male Pancreas BMD analysis (384 KB)
- Perinatal Male Testes BMD analysis (362 KB)
BMD Analyses, Chronic Study-Rats
- Adult Female Liver BMD analysis (367 KB)
- Adult Female Pancreas BMD analysis (362 KB)
- Adult Female Uterus BMD analysis (365 KB)
- Adult Male Liver BMD analysis (366 KB)
- Adult Male Pancreas BMD analysis (365 KB)
- Adult Male Testes BMD analysis (365 KB)