Multigenerational reproductive assessment of 4-methylimidazole administered in the diet to Hsd:Sprague Dawley SD rats
Mamta Behl, Cynthia J Willson, Helen Cunny, Paul M D Foster, Barry McIntyre, Cynthia Shackelford, Keith R Shockley, Sandra McBride, Katie Turner, Suramya Waidyanatha, Chad R Blystone
Reproductive Toxicology (2020)
DOI:
https://doi.org/10.1016/j.reprotox.2020.03.005
PMID:
32229253
DOI:
https://doi.org/10.22427/NTP-DATA-002-01511-0000-0000-0
Reproductive Assessment Through Continuous Breeding
Study Information
- 4-MI Readme File (15 KB)
DRF Study Tables
- I01 - Animal Removal Summary (50 KB)
- I02 - Animal Removals (310 KB)
- I03 - Growth Curve (178 KB)
- I04 - Mean Body Weights (358 KB)
- I04G - Mean Body Weight Gain (85 KB)
- I05 - Clinical Observationss Summary (160 KB)
- I05P - Pup Clinical Observations Summary (232 KB)
- I06 - Mean Feed Consumption (290 KB)
- I08 - Mean Test Compound Consumption (219 KB)
- PA46 - Gross Pathology Summary (102 KB)
- R01 - Multigeneration Cross Reference (714 KB)
- R02 - Reproductive Performance Summary (44 KB)
- R03 - Litter Data Summary (61 KB)
- R19 - Pup Mean Body Weight Summary (152 KB)
- R19G - Pup Mean Body Weight Gain (132 KB)
- R20 - Pup Necropsy Summary (59 KB)
DRF Individual Animal Data
- Individual Animal Body Weight Data (67 KB)
- Individual Animal Clinical Observations Data (184 KB)
- Individual Animal Consumption Data (85 KB)
- Individual Animal Gross Pathology Data (5 KB)
- Individual Animal Litter Data (35 KB)
- Individual Animal Pup Body Weight Data (56 KB)
- Individual Animal Pup Clinical Observations Data (275 KB)
- Individual Animal Pup Necropsy Data (5 KB)
- Individual Animal Removal Reasons Data (6 KB)
- Individual Animal Reproductive Performance Data (6 KB)
RACB Study Tables
- F0 and F1 Rats Vagcyt Plots (206 KB)
- F0 and F1 Rats VagCyt Trans Matrix (46 KB)
- F0 and F1c Parental Rats VagCyt Summary (208 KB)
- I01 - Animal Removal Summary (174 KB)
- I02 - Animal Removals (5 MB)
- I03 - Growth Curve (770 KB)
- I04 - Mean Body Weight Summary (1 MB)
- I04G - Mean Body Weight Gain (334 KB)
- I05 - Clinical Observations Summary (2 MB)
- I05P - Pup Clinical Observations Summary (920 KB)
- I06 - Mean Feed Consumption (759 KB)
- I08 - Mean Test Compound Consumption (565 KB)
- I23 - Average Dose by Phase (79 KB)
- PA02R - Neoplastic Lesion Summary with Percent and Litter Incidence (760 KB)
- PA03R - Non-Neoplastic Lesion Summary with Percent and Litter Incidence (920 KB)
- PA05R - Incidence Rates of Neoplastic Lesions with Litter Incidence Systemic Lesions Abridged (751 KB)
- PA06R - Organ Weights Summary (239 KB)
- PA08R - Statistical Analysis of Neoplastic Lesions with Litter Incidence (614 KB)
- PA10R - Statistical Analysis of Non-Neoplastic Lesions with Litter Incidence (873 KB)
- PA11 - Statistical Analysis of Survival Data (410 KB)
- PA14 - Individual Animal Pathology Data (9 MB)
- PA18R - Non-Neoplastic Lesion Summary with Severity Grade and Litter Incidence (921 KB)
- PA23 - Ovarian Follicles Summary (90 KB)
- PA40 - Survival Curve (1 MB)
- PA46R - Summary of Gross Pathology with Litter Incidence (1 MB)
- R01 - Multigeneration Cross Reference (12 MB)
- R02 - Reproductive Performance Summary (145 KB)
- R03 - Litter Data Summary (214 KB)
- R04 - Anogenital Distance Summary (120 KB)
- R06 - Andrology Summary (100 KB)
- R14 - Developmental_Markers_Summary (138 KB)
- R16 - Pubertal_Markers_Summary (152 KB)
- R19 - Pup Mean Body Weight Summary (658 KB)
- R19G - Pup Mean Body Weight Gain (461 KB)
- R20 - Pup Necropsy Summary (685 KB)
- R21 - Cross Generational Summary of Reproductive Performance (60 KB)
- R22 - Cross Generational Summary of Litters (68 KB)
RACB Individual Animal Data
- Individual Animal Andrology Data (34 KB)
- Individual Animal Body Weight Data (1 MB)
- Individual Animal Clinical Observations Data (4 MB)
- Individual Animal Consumption Data (1 MB)
- Individual Animal Developmental Markers Data (386 KB)
- Individual Animal Gross Pathology Data (521 KB)
- Individual Animal Histo Pathology Data (322 KB)
- Individual Animal Litter Crossover Data (20 KB)
- Individual Animal Litter Data (299 KB)
- Individual Animal Organ Weight Data (89 KB)
- Individual Animal Pup Body Weight Data (681 KB)
- Individual Animal Pup Clinical Observations Data (3 MB)
- Individual Animal Pup Necropsy Data (41 KB)
- Individual Animal Removal Reasons Data (54 KB)
- Individual Animal Reproductive Performance Crossover Data (9 KB)
- Individual Animal Reproductive Performance Data (28 KB)