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TR-404: 5,5-Diphenylhydantoin (57-41-0)

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Equivocal Evidence, Male, Rats
  • No Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to TR-404: 5,5-Diphenylhydantoin (57-41-0).
Rodent Cytogenetics
CA SCE
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to TR-404: 5,5-Diphenylhydantoin (57-41-0).
Micronucleus - Mice
View
  • Male: Negative
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to TR-404: 5,5-Diphenylhydantoin (57-41-0).
Mammalian Cell Mutagenicity
View
  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to TR-404: 5,5-Diphenylhydantoin (57-41-0).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to TR-404: 5,5-Diphenylhydantoin (57-41-0).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TR-404: 5,5-Diphenylhydantoin (57-41-0).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative

Citation Information

NTP. TR-404: 5,5-Diphenylhydantoin (57-41-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-404 Toxicology and Carcinogenesis Studies of 5,5-Diphenylhydantoin (Phenytoin) (CASRN 57-41-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity (C55765) of 5,5-Diphenylhydantoin (Phenytoin) (57-41-0) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C55765) of 5,5-Diphenylhydantoin (Phenytoin) (57-41-0) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 5,5-Diphenylhydantoin (Phenytoin) (57-41-0) in Micronucleus Study 110489 in BALB/c Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 5,5-Diphenylhydantoin (Phenytoin) (57-41-0) in Micronucleus Study 252424 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 5,5-Diphenylhydantoin (Phenytoin) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 255790
Summary Data
Genetic Toxicity Evaluation of 5,5-Diphenylhydantoin (Phenytoin) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 599479
Summary Data