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TR-456: 1,2-Dihydro-2,2,4-trimethylquinoline (monomer) (147-47-7)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Female, Rats
  • Some Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to TR-456: 1,2-Dihydro-2,2,4-trimethylquinoline (monomer) (147-47-7).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative (Nonstandard Protocol)
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to TR-456: 1,2-Dihydro-2,2,4-trimethylquinoline (monomer) (147-47-7).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TR-456: 1,2-Dihydro-2,2,4-trimethylquinoline (monomer) (147-47-7).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. TR-456: 1,2-Dihydro-2,2,4-trimethylquinoline (monomer) (147-47-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-456 Toxicology and Carcinogenesis Studies of 1,2-Dihydro-2,2,4-Trimethylquinoline (CASRN 147-47-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies) and the Initiation/Promotion (Dermal Study) in Female Sencar Mice

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C60902) of 1,2-Dihydro-2,2,4-trimethylquinoline (Monomer) (147-47-7) in F344/N Rats Exposed via Topical Application
3-Month Evaluation of the Toxicity (C60902) of 1,2-Dihydro-2,2,4-trimethylquinoline (Monomer) (147-47-7) in B6C3F1 Mice Exposed via Topical Application
Evaluation of the Chronic Toxicity and Carcinogenicity (C60902B) of 1,2-Dihydro-2,2,4-trimethylquinoline (Monomer) (147-47-7) in F344/N Rats Exposed via Topical Application
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C60902D) of 1,2-Dihydro-2,2,4-trimethylquinoline (Monomer) (147-47-7) in F344/N Rats Exposed via Topical Application
Evaluation of the Chronic Toxicity and Carcinogenicity (C60902B) of 1,2-Dihydro-2,2,4-trimethylquinoline (Monomer) (147-47-7) in B6C3F1 Mice Exposed via Topical Application
Evaluation of the Chronic Toxicity and Carcinogenicity (C60902D) of 1,2-Dihydro-2,2,4-trimethylquinoline (Monomer) (147-47-7) in B6C3F1 Mice Exposed via Topical Application
Initiation/Promotion Evaluation of the Toxicity (C60902B) of 1,2-Dihydro-2,2,4-trimethylquinoline (Monomer) (147-47-7) in Sencar Mice Exposed via Topical Application

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 1,2-Dihydro-2,2,4-trimethylquinoline (Monomer) (147-47-7) in Micronucleus Study A03326 in B6C3F1 Mice
Genetic Toxicity Evaluation of 1,2-Dihydro-2,2,4-trimethylquinoline (Monomer) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 246341
Summary Data