TR-582: Vinylidene chloride (75-35-4)
Study Results
Chronic Bioassay Level of Evidence
| Rats | |
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| Mice | |
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Genetic Toxicology
| Micronucleus - Mice |
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| Mammalian Cell Mutagenicity |
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| Drosophila Germ Cell Mutagenicity |
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| SLRL |
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| Bacterial Mutagenicity |
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Publications
TR-582
Toxicology and Carcinogenesis Studies of Vinylidene Chloride (CASRN 75-35-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Study Data
Toxicity and Carcinogenicity Studies
2-Week Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in F344/N Rats via Whole Body Respiratory Exposure
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
2-Week Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in B6C3F1 Mice via Whole Body Respiratory Exposure
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in F344/N Rats via Whole Body Respiratory Exposure
Study Tables
- E03 - Growth Curves (258 kB)
- E04 - Mean Body Weights and Survival Table (62 kB)
- E05 - Clinical Observations Summary (31 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (138 kB)
- P04 - Neoplasms by Individual Animal (895 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (89 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (976 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (65 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (96 kB)
- P40 - Survival Curves (232 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (37 kB)
- Female Individual Animal Non Neoplastic Pathology Data (63 kB)
- Female Individual Animal Organ Weight Data (19 kB)
- Female Individual Animal Survival Data (11 kB)
- Male Individual Animal Body Weight Data (37 kB)
- Male Individual Animal Non Neoplastic Pathology Data (79 kB)
- Male Individual Animal Organ Weight Data (19 kB)
- Male Individual Animal Survival Data (11 kB)
3-Month Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in B6C3F1 Mice via Whole Body Respiratory Exposure
Study Tables
- E03 - Growth Curves (255 kB)
- E04 - Mean Body Weights and Survival Table (118 kB)
- E05 - Clinical Observations Summary (29 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (198 kB)
- P04 - Neoplasms by Individual Animal (2 mB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (102 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (1 mB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (175 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (163 kB)
- P40 - Survival Curves (245 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (36 kB)
- Female Individual Animal Clinical Observations (2 kB)
- Female Individual Animal Non Neoplastic Pathology Data (102 kB)
- Female Individual Animal Organ Weight Data (19 kB)
- Female Individual Animal Survival Data (11 kB)
- Male Individual Animal Body Weight Data (30 kB)
- Male Individual Animal Clinical Observations (2 kB)
- Male Individual Animal Non Neoplastic Pathology Data (40 kB)
- Male Individual Animal Organ Weight Data (17 kB)
- Male Individual Animal Survival Data (10 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C20303) of Vinylidene Chloride (75-35-4) in F344/N Rats via Whole Body Respiratory Exposure
Study Tables
- E03 - Growth Curves (65 kB)
- E04 - Mean Body Weights and Survival Table (24 kB)
- E05 - Clinical Observations Summary (24 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (55 kB)
- P04 - Neoplasms by Individual Animal (806 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (52 kB)
- P08 - Statistical Analysis of Primary Tumors (278 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (797 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (395 kB)
- P11 - Statistical Analysis of Survival Data (28 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (652 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (57 kB)
- P40 - Survival Curves (67 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (379 kB)
- Female Individual Animal Clinical Observations (322 kB)
- Female Individual Animal Neoplastic Pathology Data (348 kB)
- Female Individual Animal Non Neoplastic Pathology Data (757 kB)
- Female Individual Animal Organ Weight Data (57 kB)
- Female Individual Animal Survival Data (34 kB)
- Male Individual Animal Body Weight Data (410 kB)
- Male Individual Animal Clinical Observations (170 kB)
- Male Individual Animal Neoplastic Pathology Data (452 kB)
- Male Individual Animal Non Neoplastic Pathology Data (768 kB)
- Male Individual Animal Organ Weight Data (57 kB)
- Male Individual Animal Survival Data (33 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C20303) of Vinylidene Chloride (75-35-4) in B6C3F1 Mice via Whole Body Respiratory Exposure
Study Tables
- E03 - Growth Curves (71 kB)
- E04 - Mean Body Weights and Survival Table (24 kB)
- E05 - Clinical Observations Summary (20 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (54 kB)
- P04 - Neoplasms by Individual Animal (727 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (50 kB)
- P08 - Statistical Analysis of Primary Tumors (213 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (802 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (360 kB)
- P11 - Statistical Analysis of Survival Data (24 kB)
- P14 - Individual Animal Pathology Data (1 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (665 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (56 kB)
- P40 - Survival Curves (65 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (409 kB)
- Female Individual Animal Clinical Observations (82 kB)
- Female Individual Animal Neoplastic Pathology Data (238 kB)
- Female Individual Animal Non Neoplastic Pathology Data (538 kB)
- Female Individual Animal Organ Weight Data (57 kB)
- Female Individual Animal Survival Data (34 kB)
- Male Individual Animal Body Weight Data (393 kB)
- Male Individual Animal Clinical Observations (91 kB)
- Male Individual Animal Neoplastic Pathology Data (197 kB)
- Male Individual Animal Non Neoplastic Pathology Data (483 kB)
- Male Individual Animal Organ Weight Data (57 kB)
- Male Individual Animal Survival Data (33 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Vinylidene Chloride (75-35-4) in Micronucleus Study A71539 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Vinylidene Chloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 121030
Summary Data
- G06 - Ames Summary Data (167 KB)