TR-584: Indole-3-carbinol (700-06-1)

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View No Evidence, Male, Rats Some Evidence, Female, Rats

An overview of chronic evidence from Mice studies.
Mice
View Clear Evidence, Male, Mice No Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Rats study conclusions related to TR-584: Indole-3-carbinol (700-06-1).
Micronucleus - Rats
View Male: Negative

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to TR-584: Indole-3-carbinol (700-06-1).
Micronucleus - Mice
View Male: Negative Female: Negative

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TR-584: Indole-3-carbinol (700-06-1).
Bacterial Mutagenicity
View Equivocal
View Positive

Citation Information

NTP. TR-584: Indole-3-carbinol (700-06-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

TR-584 Toxicology Studies of Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Indole-3-Carbinol in Harlan Sprague Dawley Rats and B6C3F1/N Mice (Gavage Studies)

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Data

3-Month Evaluation of the Toxicity (C20006) of Indole-3-carbinol (700-06-1) in F344/N Rats Exposed via Gavage

Study Tables

E03 - Growth Curves (363 kB)
E04 - Mean Body Weights and Survival Table (59 kB)
E05 - Clinical Observations Summary (90 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (147 kB)
P04 - Neoplasms by Individual Animal (967 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (192 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (1 mB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (143 kB)
P14 - Individual Animal Pathology Data (2 mB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (151 kB)
P40 - Survival Curves (382 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (37 kB)
Female Individual Animal Clinical Observations (3 kB)
Female Individual Animal Non Neoplastic Pathology Data (55 kB)
Female Individual Animal Organ Weight Data (19 kB)
Female Individual Animal Survival Data (11 kB)
Male Individual Animal Body Weight Data (37 kB)
Male Individual Animal Clinical Observations (2 kB)
Male Individual Animal Non Neoplastic Pathology Data (63 kB)
Male Individual Animal Organ Weight Data (19 kB)
Male Individual Animal Survival Data (11 kB)

Data

3-Month Evaluation of the Toxicity (C20006) of Indole-3-carbinol (700-06-1) in B6C3F1 Mice Exposed via Gavage

Study Tables

E03 - Growth Curves (361 kB)
E04 - Mean Body Weights and Survival Table (193 kB)
E05 - Clinical Observations Summary (51 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (156 kB)
P04 - Neoplasms by Individual Animal (933 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (174 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (896 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (176 kB)
P14 - Individual Animal Pathology Data (261 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (197 kB)
P40 - Survival Curves (378 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (34 kB)
Female Individual Animal Non Neoplastic Pathology Data (22 kB)
Female Individual Animal Organ Weight Data (19 kB)
Female Individual Animal Survival Data (11 kB)
Male Individual Animal Body Weight Data (36 kB)
Male Individual Animal Clinical Observations (2 kB)
Male Individual Animal Non Neoplastic Pathology Data (18 kB)
Male Individual Animal Organ Weight Data (19 kB)
Male Individual Animal Survival Data (11 kB)

Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C20006B) of Indole-3-carbinol (700-06-1) in Harlan Sprague-Dawley Rats Exposed via Gavage

Study Tables

E03 - Growth Curves (67 kB)
E04 - Mean Body Weights and Survival Table (24 kB)
E05 - Clinical Observations Summary (20 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (55 kB)
P04 - Neoplasms by Individual Animal (657 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (48 kB)
P08 - Statistical Analysis of Primary Tumors (226 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (800 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (398 kB)
P11 - Statistical Analysis of Survival Data (28 kB)
P14 - Individual Animal Pathology Data (1 mB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (598 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (57 kB)
P40 - Survival Curves (70 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (433 kB)
Female Individual Animal Clinical Observations (215 kB)
Female Individual Animal Neoplastic Pathology Data (126 kB)
Female Individual Animal Non Neoplastic Pathology Data (687 kB)
Female Individual Animal Organ Weight Data (57 kB)
Female Individual Animal Survival Data (34 kB)
Male Individual Animal Body Weight Data (427 kB)
Male Individual Animal Clinical Observations (173 kB)
Male Individual Animal Neoplastic Pathology Data (75 kB)
Male Individual Animal Non Neoplastic Pathology Data (879 kB)
Male Individual Animal Organ Weight Data (57 kB)
Male Individual Animal Survival Data (33 kB)

Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C20006B) of Indole-3-carbinol (700-06-1) in B6C3F1 Mice Exposed via Gavage

Study Tables

E03 - Growth Curves (68 kB)
E04 - Mean Body Weights and Survival Table (24 kB)
E05 - Clinical Observations Summary (20 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (54 kB)
P04 - Neoplasms by Individual Animal (674 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (48 kB)
P08 - Statistical Analysis of Primary Tumors (199 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (753 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (350 kB)
P11 - Statistical Analysis of Survival Data (24 kB)
P14 - Individual Animal Pathology Data (1 mB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (599 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (55 kB)
P40 - Survival Curves (65 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (350 kB)
Female Individual Animal Clinical Observations (47 kB)
Female Individual Animal Neoplastic Pathology Data (120 kB)
Female Individual Animal Non Neoplastic Pathology Data (699 kB)
Female Individual Animal Organ Weight Data (57 kB)
Female Individual Animal Survival Data (34 kB)
Male Individual Animal Body Weight Data (397 kB)
Male Individual Animal Clinical Observations (88 kB)
Male Individual Animal Neoplastic Pathology Data (152 kB)
Male Individual Animal Non Neoplastic Pathology Data (666 kB)
Male Individual Animal Organ Weight Data (57 kB)
Male Individual Animal Survival Data (34 kB)

Protocol

Genetic Toxicology Studies

Data

Genetic Toxicity Evaluation of Indole-3-carbinol (700-06-1) in Micronucleus Study A31749 in F344 Rats

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (45 KB)
Individual Animal In Vivo Micronucleus Data (7 KB)

Data

Genetic Toxicity Evaluation of Indole-3-carbinol (700-06-1) in Micronucleus Study A94530 in B6C3F1 Mice

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (69 KB)
Individual Animal In Vivo Micronucleus Data (9 KB)

Data

Genetic Toxicity Evaluation of Indole-3-carbinol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A34549

Summary Data

G06 - Ames Summary Data (183 KB)

Data

Genetic Toxicity Evaluation of Indole-3-carbinol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A35905

Summary Data

G06 - Ames Summary Data (261 KB)

TR-584: Indole-3-carbinol (700-06-1)

Study Results

Chronic Bioassay Level of Evidence

Genetic Toxicology

Citation Information

Related Links

Publications

Study Data

Toxicity and Carcinogenicity Studies

3-Month Evaluation of the Toxicity (C20006) of Indole-3-carbinol (700-06-1) in F344/N Rats Exposed via Gavage

Study Tables

Individual Animal Data

3-Month Evaluation of the Toxicity (C20006) of Indole-3-carbinol (700-06-1) in B6C3F1 Mice Exposed via Gavage

Study Tables

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C20006B) of Indole-3-carbinol (700-06-1) in Harlan Sprague-Dawley Rats Exposed via Gavage

Study Tables

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C20006B) of Indole-3-carbinol (700-06-1) in B6C3F1 Mice Exposed via Gavage

Study Tables

Individual Animal Data

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Indole-3-carbinol (700-06-1) in Micronucleus Study A31749 in F344 Rats

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Indole-3-carbinol (700-06-1) in Micronucleus Study A94530 in B6C3F1 Mice

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Indole-3-carbinol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A34549

Summary Data

Genetic Toxicity Evaluation of Indole-3-carbinol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A35905

Summary Data