Indole-3-carbinol (700-06-1)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID7031458
Study Results
Chronic Bioassay Level of Evidence
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| Mice | |
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Genetic Toxicology
| Micronucleus - Rats |
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| Micronucleus - Mice |
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| Bacterial Mutagenicity |
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Publications
TR-584
Toxicology Studies of Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Indole-3-Carbinol in Harlan Sprague Dawley Rats and B6C3F1/N Mice (Gavage Studies)
Study Data
Toxicity and Carcinogenicity Studies
26-Week Evaluation of the Toxicity (C20010A) of Prevention 4 (Indole-3-carbinol) (700-06-1) in Tg.NK Mice Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C20006) of Indole-3-carbinol (700-06-1) in F344/N Rats Exposed via Gavage
Study Tables
- E03 - Growth Curves (363 kB)
- E04 - Mean Body Weights and Survival Table (59 kB)
- E05 - Clinical Observations Summary (90 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (147 kB)
- P04 - Neoplasms by Individual Animal (967 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (192 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (1 mB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (143 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (151 kB)
- P40 - Survival Curves (382 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (37 kB)
- Female Individual Animal Clinical Observations (3 kB)
- Female Individual Animal Non Neoplastic Pathology Data (55 kB)
- Female Individual Animal Organ Weight Data (19 kB)
- Female Individual Animal Survival Data (11 kB)
- Male Individual Animal Body Weight Data (37 kB)
- Male Individual Animal Clinical Observations (2 kB)
- Male Individual Animal Non Neoplastic Pathology Data (63 kB)
- Male Individual Animal Organ Weight Data (19 kB)
- Male Individual Animal Survival Data (11 kB)
3-Month Evaluation of the Toxicity (C20006) of Indole-3-carbinol (700-06-1) in B6C3F1 Mice Exposed via Gavage
Study Tables
- E03 - Growth Curves (361 kB)
- E04 - Mean Body Weights and Survival Table (193 kB)
- E05 - Clinical Observations Summary (51 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (156 kB)
- P04 - Neoplasms by Individual Animal (933 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (174 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (896 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (176 kB)
- P14 - Individual Animal Pathology Data (261 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (197 kB)
- P40 - Survival Curves (378 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (34 kB)
- Female Individual Animal Non Neoplastic Pathology Data (22 kB)
- Female Individual Animal Organ Weight Data (19 kB)
- Female Individual Animal Survival Data (11 kB)
- Male Individual Animal Body Weight Data (36 kB)
- Male Individual Animal Clinical Observations (2 kB)
- Male Individual Animal Non Neoplastic Pathology Data (18 kB)
- Male Individual Animal Organ Weight Data (19 kB)
- Male Individual Animal Survival Data (11 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C20006B) of Indole-3-carbinol (700-06-1) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
- E03 - Growth Curves (67 kB)
- E04 - Mean Body Weights and Survival Table (24 kB)
- E05 - Clinical Observations Summary (20 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (55 kB)
- P04 - Neoplasms by Individual Animal (657 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (48 kB)
- P08 - Statistical Analysis of Primary Tumors (226 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (800 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (398 kB)
- P11 - Statistical Analysis of Survival Data (28 kB)
- P14 - Individual Animal Pathology Data (1 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (598 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (57 kB)
- P40 - Survival Curves (70 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (433 kB)
- Female Individual Animal Clinical Observations (215 kB)
- Female Individual Animal Neoplastic Pathology Data (126 kB)
- Female Individual Animal Non Neoplastic Pathology Data (687 kB)
- Female Individual Animal Organ Weight Data (57 kB)
- Female Individual Animal Survival Data (34 kB)
- Male Individual Animal Body Weight Data (427 kB)
- Male Individual Animal Clinical Observations (173 kB)
- Male Individual Animal Neoplastic Pathology Data (75 kB)
- Male Individual Animal Non Neoplastic Pathology Data (879 kB)
- Male Individual Animal Organ Weight Data (57 kB)
- Male Individual Animal Survival Data (33 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C20006B) of Indole-3-carbinol (700-06-1) in B6C3F1 Mice Exposed via Gavage
Study Tables
- E03 - Growth Curves (68 kB)
- E04 - Mean Body Weights and Survival Table (24 kB)
- E05 - Clinical Observations Summary (20 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (54 kB)
- P04 - Neoplasms by Individual Animal (674 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (48 kB)
- P08 - Statistical Analysis of Primary Tumors (199 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (753 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (350 kB)
- P11 - Statistical Analysis of Survival Data (24 kB)
- P14 - Individual Animal Pathology Data (1 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (599 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (55 kB)
- P40 - Survival Curves (65 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (350 kB)
- Female Individual Animal Clinical Observations (47 kB)
- Female Individual Animal Neoplastic Pathology Data (120 kB)
- Female Individual Animal Non Neoplastic Pathology Data (699 kB)
- Female Individual Animal Organ Weight Data (57 kB)
- Female Individual Animal Survival Data (34 kB)
- Male Individual Animal Body Weight Data (397 kB)
- Male Individual Animal Clinical Observations (88 kB)
- Male Individual Animal Neoplastic Pathology Data (152 kB)
- Male Individual Animal Non Neoplastic Pathology Data (666 kB)
- Male Individual Animal Organ Weight Data (57 kB)
- Male Individual Animal Survival Data (34 kB)
Special Evaluation of the Toxicity (C20006B) of Indole-3-carbinol (700-06-1) in Sprague-Dawley Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Indole-3-carbinol (700-06-1) in Micronucleus Study A31749 in F344 Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Indole-3-carbinol (700-06-1) in Micronucleus Study A94530 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Indole-3-carbinol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A34549
Summary Data
- G06 - Ames Summary Data (183 KB)
Genetic Toxicity Evaluation of Indole-3-carbinol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A35905
Summary Data
- G06 - Ames Summary Data (261 KB)
Genetic Toxicity Evaluation of Prevention 4 (Indole-3-carbinol) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A51566
Summary Data
- G06 - Ames Summary Data (111 KB)