TR-593: 2,3-Butanedione (431-03-8)

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Rats study conclusions related to TR-593: 2,3-Butanedione (431-03-8).
Micronucleus - Rats
View Male: Negative Female: Negative

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to TR-593: 2,3-Butanedione (431-03-8).
Micronucleus - Mice
View Male: Negative
View Male: Negative Female: Negative

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TR-593: 2,3-Butanedione (431-03-8).
Bacterial Mutagenicity
View Weakly Positive
View Positive

Citation Information

NTP. TR-593: 2,3-Butanedione (431-03-8). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

TR-593 Toxicology and Carcinogenesis Studies of 2,3-Butanedione in Wistar Han [Crl:WI (Han)] Rats and B6C3F1/N Mice

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Data

3-Month Evaluation of the Toxicity (C20725) of 2,3-Butanedione (431-03-8) in Wistar Han Rats via Whole Body Respiratory Exposure

Study Tables

E03 - Growth Curves (65 kB)
E04 - Mean Body Weights and Survival Table (18 kB)
E05 - Clinical Observations Summary (18 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (38 kB)
P04 - Neoplasms by Individual Animal (214 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (249 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (307 kB)
P14 - Individual Animal Pathology Data (312 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (39 kB)
P40 - Survival Curves (435 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (35 kB)
Female Individual Animal Non Neoplastic Pathology Data (101 kB)
Female Individual Animal Survival Data (11 kB)
Female Individual Animal Terminal Body Weight Data (19 kB)
Female Individual Clinical Observations (14 kB)
Individual Animal Clinical Chemistry Data (32 kB)
Individual Animal Hematology Data (57 kB)
Individual Animal Organ Weight Data (13 kB)
Male Individual Animal Body Weight Data (37 kB)
Male Individual Animal Non Neoplastic Pathology Data (100 kB)
Male Individual Animal Survival Data (11 kB)
Male Individual Animal Terminal_Body Weight Data (19 kB)
Male Individual Clinical Observations (15 kB)

Data

3-Month Evaluation of the Toxicity (C20725) of 2,3-Butanedione (431-03-8) in B6C3F1 Mice via Whole Body Respiratory Exposure

Study Tables

E03 - Growth Curves (441 kB)
E04 - Mean Body Weights and Survival Table (18 kB)
E05 - Clinical Observations Summary (18 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (35 kB)
P04 - Neoplasms by Individual Animal (213 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (34 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (242 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (232 kB)
P14 - Individual Animal Pathology Data (317 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (37 kB)
P40 - Survival Curves (435 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (36 kB)
Female Individual Animal Clinical Observations (13 kB)
Female Individual Animal Non Neoplastic Pathology Data (120 kB)
Female Individual Animal Survival Data (11 kB)
Female Individual Animal Terminal Body Weight Data (19 kB)
Individual Animal Hematology Data (23 kB)
Individual Animal Organ Weight Data (12 kB)
Male Individual Animal Body Weight Data (36 kB)
Male Individual Animal Clinical Observations (15 kB)
Male Individual Animal Non Neoplastic Pathology Data (122 kB)
Male Individual Animal Survival Data (11 kB)
Male Individual Animal Terminal Body Weight Data (19 kB)

Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C20725) of 2,3-Butanedione (431-03-8) in Wistar Han Rats via Whole Body Respiratory Exposure

Study Tables

E03 - Growth Curves (71 kB)
E04 - Mean Body Weights and Survival Table (25 kB)
E05 - Clinical Observations Summary (25 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (60 kB)
P04 - Neoplasms by Individual Animal (648 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (48 kB)
P08 - Statistical Analysis of Primary Tumors (192 kB)
P08 - Statistical Analysis of Primary Tumors-Custom Nose (22 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (907 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (526 kB)
P11 - Statistical Analysis of Survival Data (24 kB)
P14 - Individual Animal Pathology Data (1 mB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (607 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (63 kB)
P40 - Survival Curves (446 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (367 kB)
Female Individual Animal Clinical Observations (271 kB)
Female Individual Animal Neoplastic Pathology Data (119 kB)
Female Individual Animal Non Neoplastic Pathology Data (967 kB)
Female Individual Animal Survival Data (34 kB)
Female Individual Animal Terminal Body Weight Data (57 kB)
Male Individual Animal Body Weight Data (378 kB)
Male Individual Animal Clinical Observations (272 kB)
Male Individual Animal Neoplastic Pathology Data (77 kB)
Male Individual Animal Non Neoplastic Pathology Data (941 kB)
Male Individual Animal Survival Data (33 kB)
Male Individual Animal Terminal Body Weight Data (57 kB)

Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C20725) of 2,3-Butanedione (431-03-8) in B6C3F1 Mice via Whole Body Respiratory Exposure

Study Tables

E03 - Growth Curves (454 kB)
E04 - Mean Body Weights and Survival Table (24 kB)
E05 - Clinical Observations Summary (20 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (70 kB)
P04 - Neoplasms by Individual Animal (748 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (52 kB)
P08 - Statistical Analysis of Primary Tumors (141 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (954 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (712 kB)
P11 - Statistical Analysis of Survival Data (24 kB)
P14 - Individual Animal Pathology Data (2 mB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (632 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (72 kB)
P40 - Survival Curves (443 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (409 kB)
Female Individual Animal Clinical Observations (140 kB)
Female Individual Animal Neoplastic Pathology Data (172 kB)
Female Individual Animal Non Neoplastic Pathology Data (915 kB)
Female Individual Animal Survival Data (33 kB)
Female Individual Animal Terminal Body Weight Data (57 kB)
Male Individual Animal Body Weight Data (393 kB)
Male Individual Animal Clinical Observations (84 kB)
Male Individual Animal Neoplastic Pathology Data (122 kB)
Male Individual Animal Non Neoplastic Pathology Data (812 kB)
Male Individual Animal Survival Data (33 kB)
Male Individual Animal Terminal Body Weight Data (57 kB)

Protocol

Genetic Toxicology Studies

Data

Genetic Toxicity Evaluation of 2,3-Butanedione (431-03-8) in Micronucleus Study A44706 in B6C3F1 Mice

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (54 KB)
Individual Animal In Vivo Micronucleus Data (8 KB)

Data

Genetic Toxicity Evaluation of 2,3-Butanedione (431-03-8) in Micronucleus Study G94009 in Wistar Han Rats

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (77 KB)
Individual Animal In Vivo Micronucleus Data (10 KB)

Data

Genetic Toxicity Evaluation of 2,3-Butanedione (431-03-8) in Micronucleus Study G94009B in B6C3F1 Mice

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (77 KB)
Individual Animal In Vivo Micronucleus Data (10 KB)

Data

Genetic Toxicity Evaluation of 2,3-Butanedione in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A04292

Summary Data

G06 - Ames Summary Data (186 KB)

Data

Genetic Toxicity Evaluation of 2,3-Butanedione in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G94009C

Summary Data

G06 - Ames Summary Data (102 KB)

TR-593: 2,3-Butanedione (431-03-8)

Study Results

Genetic Toxicology

Citation Information

Related Links

Publications

Study Data

Toxicity and Carcinogenicity Studies

3-Month Evaluation of the Toxicity (C20725) of 2,3-Butanedione (431-03-8) in Wistar Han Rats via Whole Body Respiratory Exposure

Study Tables

Individual Animal Data

3-Month Evaluation of the Toxicity (C20725) of 2,3-Butanedione (431-03-8) in B6C3F1 Mice via Whole Body Respiratory Exposure

Study Tables

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C20725) of 2,3-Butanedione (431-03-8) in Wistar Han Rats via Whole Body Respiratory Exposure

Study Tables

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C20725) of 2,3-Butanedione (431-03-8) in B6C3F1 Mice via Whole Body Respiratory Exposure

Study Tables

Individual Animal Data

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 2,3-Butanedione (431-03-8) in Micronucleus Study A44706 in B6C3F1 Mice

Summary and Individual Animal Data

Genetic Toxicity Evaluation of 2,3-Butanedione (431-03-8) in Micronucleus Study G94009 in Wistar Han Rats

Summary and Individual Animal Data

Genetic Toxicity Evaluation of 2,3-Butanedione (431-03-8) in Micronucleus Study G94009B in B6C3F1 Mice

Summary and Individual Animal Data

Genetic Toxicity Evaluation of 2,3-Butanedione in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A04292

Summary Data

Genetic Toxicity Evaluation of 2,3-Butanedione in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G94009C

Summary Data