2,3-Butanedione (431-03-8)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID6021583
Publications
TR-593
Toxicology and Carcinogenesis Studies of 2,3-Butanedione in Wistar Han [Crl:WI (Han)] Rats and B6C3F1/N Mice
Airway Injury in an in vitro Human Epithelium-Fibroblast Model of Diacetyl Vapor Exposure: Diacetyl-Induced Basal/Suprabasal Spongiosis
William M. Gwinn, Gordon P. Flake, Ronald W. Bousquet, Genie J. Taylor, and Daniel L. Morgan.
Inhalation Toxicology (2017) DOI: https://doi.org/10.1080/08958378.2017.1369604 PMID: 28984536
Inhalation Toxicology (2017) DOI: https://doi.org/10.1080/08958378.2017.1369604 PMID: 28984536
Study Data
Toxicity and Carcinogenicity Studies
18-33 Day Evaluation of the Toxicity (I20606) of 2,3 Butanedione (431-03-8) in BALB/c Mice via Whole Body Respiratory Exposure
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C20725) of 2,3-Butanedione (431-03-8) in Wistar Han Rats via Whole Body Respiratory Exposure
Study Tables
- E03 - Growth Curves (71 kB)
- E04 - Mean Body Weights and Survival Table (25 kB)
- E05 - Clinical Observations Summary (25 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (60 kB)
- P04 - Neoplasms by Individual Animal (648 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (48 kB)
- P08 - Statistical Analysis of Primary Tumors (192 kB)
- P08 - Statistical Analysis of Primary Tumors-Custom Nose (22 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (907 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (526 kB)
- P11 - Statistical Analysis of Survival Data (24 kB)
- P14 - Individual Animal Pathology Data (1 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (607 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (63 kB)
- P40 - Survival Curves (446 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (367 kB)
- Female Individual Animal Clinical Observations (271 kB)
- Female Individual Animal Neoplastic Pathology Data (119 kB)
- Female Individual Animal Non Neoplastic Pathology Data (967 kB)
- Female Individual Animal Survival Data (34 kB)
- Female Individual Animal Terminal Body Weight Data (57 kB)
- Male Individual Animal Body Weight Data (378 kB)
- Male Individual Animal Clinical Observations (272 kB)
- Male Individual Animal Neoplastic Pathology Data (77 kB)
- Male Individual Animal Non Neoplastic Pathology Data (941 kB)
- Male Individual Animal Survival Data (33 kB)
- Male Individual Animal Terminal Body Weight Data (57 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C20725) of 2,3-Butanedione (431-03-8) in B6C3F1 Mice via Whole Body Respiratory Exposure
Study Tables
- E03 - Growth Curves (454 kB)
- E04 - Mean Body Weights and Survival Table (24 kB)
- E05 - Clinical Observations Summary (20 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (70 kB)
- P04 - Neoplasms by Individual Animal (748 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (52 kB)
- P08 - Statistical Analysis of Primary Tumors (141 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (954 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (712 kB)
- P11 - Statistical Analysis of Survival Data (24 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (632 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (72 kB)
- P40 - Survival Curves (443 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (409 kB)
- Female Individual Animal Clinical Observations (140 kB)
- Female Individual Animal Neoplastic Pathology Data (172 kB)
- Female Individual Animal Non Neoplastic Pathology Data (915 kB)
- Female Individual Animal Survival Data (33 kB)
- Female Individual Animal Terminal Body Weight Data (57 kB)
- Male Individual Animal Body Weight Data (393 kB)
- Male Individual Animal Clinical Observations (84 kB)
- Male Individual Animal Neoplastic Pathology Data (122 kB)
- Male Individual Animal Non Neoplastic Pathology Data (812 kB)
- Male Individual Animal Survival Data (33 kB)
- Male Individual Animal Terminal Body Weight Data (57 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of 2,3-Butanedione (431-03-8) in Micronucleus Study A44706 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 2,3-Butanedione (431-03-8) in Micronucleus Study G94009 in Wistar Han Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 2,3-Butanedione (431-03-8) in Micronucleus Study G94009B in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 2,3-Butanedione in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A04292
Summary Data
- G06 - Ames Summary Data (186 KB)
Genetic Toxicity Evaluation of 2,3-Butanedione in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G94009C
Summary Data
- G06 - Ames Summary Data (102 KB)