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2,3-Butanedione (431-03-8)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID6021583


Study Results


Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 2,3-Butanedione (431-03-8).
Micronucleus - Mice
View
  • Male: Negative
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Micronucleus Rats study conclusions related to 2,3-Butanedione (431-03-8).
Micronucleus - Rats
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 2,3-Butanedione (431-03-8).
Bacterial Mutagenicity
View
  • Positive
View
  • Weakly Positive

Citation Information


NTP. 2,3-Butanedione (431-03-8). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-593 Toxicology and Carcinogenesis Studies of 2,3-Butanedione in Wistar Han [Crl:WI (Han)] Rats and B6C3F1/N Mice
Airway Injury in an in vitro Human Epithelium-Fibroblast Model of Diacetyl Vapor Exposure: Diacetyl-Induced Basal/Suprabasal Spongiosis William M. Gwinn, Gordon P. Flake, Ronald W. Bousquet, Genie J. Taylor, and Daniel L. Morgan.
Inhalation Toxicology (2017) DOI: https://doi.org/10.1080/08958378.2017.1369604 PMID: 28984536

Study Data


Toxicity and Carcinogenicity Studies


18-33 Day Evaluation of the Toxicity (I20606) of 2,3 Butanedione (431-03-8) in BALB/c Mice via Whole Body Respiratory Exposure
3-Month Evaluation of the Toxicity (C20725) of 2,3-Butanedione (431-03-8) in Wistar Han Rats via Whole Body Respiratory Exposure
3-Month Evaluation of the Toxicity (C20725) of 2,3-Butanedione (431-03-8) in B6C3F1 Mice via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity (C20725) of 2,3-Butanedione (431-03-8) in Wistar Han Rats via Whole Body Respiratory Exposure
Study Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C20725) of 2,3-Butanedione (431-03-8) in B6C3F1 Mice via Whole Body Respiratory Exposure
Study Tables
Individual Animal Data

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 2,3-Butanedione (431-03-8) in Micronucleus Study A44706 in B6C3F1 Mice
Genetic Toxicity Evaluation of 2,3-Butanedione (431-03-8) in Micronucleus Study G94009 in Wistar Han Rats
Genetic Toxicity Evaluation of 2,3-Butanedione (431-03-8) in Micronucleus Study G94009B in B6C3F1 Mice
Genetic Toxicity Evaluation of 2,3-Butanedione in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A04292
Summary Data
Genetic Toxicity Evaluation of 2,3-Butanedione in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G94009C
Summary Data