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TR-606: alpha-Pinene (80-56-8)

Citation Information

NTP. TR-606: alpha-Pinene (80-56-8). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

TR-606 NTP Technical Report on the Toxicology and Carcinogenesis Studies of α-Pinene (CASRN 80-56-8) Administered by Inhalation to Sprague Dawley (Hsd:Sprague Dawley SD) Rats, B6C3F1/N Mice, and CD-1 Mice

Study Data

Protocol

Toxicity and Carcinogenicity Studies

3-Month Investigative Study of the Toxicity (C20302B) of alpha-Pinene (80-56-8) in Harlan Sprague Dawley Rats via Whole Body Respiratory Exposure

Study Tables

I01 - Animal_Removal_Summary (83 kB)
I02 - Animal_Removals (453 kB)
I03 - Growth_Curve (595 kB)
I03C - Growth_Curve (559 kB)
I04 - Mean_Body_Weight_Summary (182 kB)
I04G - Mean_Body_Weight_Gain (168 kB)
I05 - Clinical_Observations_Summary (111 kB)
PA02 - Neoplastic Lesion Summary with Percent Incidence (230 kB)
PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (195 kB)
PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (230 kB)
PA06 - Organ Weights Summary (82 kB)
PA10X - Statistical Analysis of Non-Neoplastic Lesions (220 kB)
PA14 - Individual Animal Pathology Data (1 mB)
PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (196 kB)
PA46s - Summary of Gross Pathology (214 kB)
PA48 - Summary of Internal Concentration (34 kB)
R06 - Andrology Summary (99 kB)
Vaginal Cytology CMTC Results (11 kB)
Vaginal Cytology CMTC Results (183 kB)
Vaginal Cytology Plots (142 kB)
Vaginal Cytology Summary (124 kB)
Vaginal Cytology Summary (9 kB)

Individual Animal Data

Individual Animal Andrology Data (9 kB)
Individual Animal Body Weight Data (53 kB)
Individual Animal Clinical Observations Data (55 kB)
Individual Animal Gross Pathology Data (29 kB)
Individual Animal Internal Concentration (17 kB)
Individual Animal Organ Weight Data (8 kB)
Individual Animal Removal Reasons Data (9 kB)

3-Month Reproductive and Chronic Evaluation of the Toxicity (C20302B) of alpha-Pinene (80-56-8) in Harlan Sprague Dawley Rats via Whole Body Respiratory Exposure

Study Tables

I01 - Animal_Removal_Summary (153 kB)
I02 - Animal_Removals (803 kB)
I03 - Growth_Curve (619 kB)
I03C - Growth_Curve (580 kB)
I04 - Mean_Body_Weight_Summary (184 kB)
I04G - Mean_Body_Weight_Gain (176 kB)
I05 - Clinical_Observations_Summary (131 kB)
PA02 - Neoplastic Lesion Summary with Percent Incidence (112 kB)
PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (112 kB)
PA04 - Neoplasms by Individual Animal (1 mB)
PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (112 kB)
PA06 - Organ Weights Summary (115 kB)
PA07 - Neoplasms by Individual Animal (Systemic Lesions Abridged) (1 mB)
PA09 - Non-Neoplastic Lesions by Individual Animal (1 mB)
PA10 - Statistical Analysis of Non-Neoplastic Lesions (118 kB)
PA14 - Individual Animal Pathology Data (4 mB)
PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (333 kB)
PA46s - Summary of Gross Pathology (176 kB)
R02 - Reproductive Performance Summary (111 kB)
R09 - Uterine Content Summary (133 kB)

Individual Animal Data

Individual Animal Body Weight Data (94 kB)
Individual Animal Clinical Observations Data (103 kB)
Individual Animal Gross Pathology Data (29 kB)
Individual Animal Histopathology Data (22 kB)
Individual Animal Organ Weight Data (16 kB)
Individual Animal Removal Reasons Data (19 kB)
Individual Animal Teratology Dam Data (15 kB)
Individual Animal Teratology Fetal Weight Data (47 kB)
Individual Animal Teratology Implant Findings Data (64 kB)

3-Month Reproductive Evaluation of the Toxicity (C20302B) of alpha-Pinene (80-56-8) in CD-1 Mice via Whole Body Respiratory Exposure

Study Tables

I01 - Animal_Removal_Summary (110 kB)
I02 - Animal_Removals (2 mB)
I03 - Growth_Curve (1 mB)
I03C - Growth_Curve (1 mB)
I04 - Mean_Body_Weight_Summary (462 kB)
I04G - Mean_Body_Weight_Gain (399 kB)
I05 - Clinical_Observations_Summary (1 mB)
PA02 - Neoplastic Lesion Summary with Percent Incidence (795 kB)
PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (1 mB)
PA04 - Neoplasms by Individual Animal (14 mB)
PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (700 kB)
PA06 - Organ Weights Summary (82 kB)
PA07 - Neoplasms by Individual Animal (Systemic Lesions Abridged) (14 mB)
PA08 - Chronic Animals: Statistical Analysis of Neoplastic Lesions (10 mB)
PA09 - Non-Neoplastic Lesions by Individual Animal (23 mB)
PA10 - Statistical Analysis of Non-Neoplastic Lesions (18 mB)
PA11 - Statistical Analysis of Survival Data (125 kB)
PA14 - Individual Animal Pathology Data (31 mB)
PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (1 mB)
PA40 - Survival Curve (533 kB)
PA40C - Survival Curve (472 kB)
PA46s - Summary of Gross Pathology (1 mB)
PA48 - Summary of Internal Concentration (35 kB)
R01 - Multigeneration Cross Reference (401 kB)
R02 - Reproductive Performance Summary (77 kB)
R09 - Uterine Content Summary (104 kB)

Individual Animal Data

Individual Animal Body Weight Data (528 kB)
Individual Animal Clinical Observations Data (400 kB)
Individual Animal Gross Pathology Data (1 mB)
Individual Animal HistoPathologySlideReview Data (930 kB)
Individual Animal Internal Concentration (19 kB)
Individual Animal Organ Weight Data (10 kB)
Individual Animal Removal Reasons Data (29 kB)
Individual Animal Reproductive Performance Data (9 kB)
Individual Animal Teratology Dam Data (9 kB)
Individual Animal Teratology Fetal Weight Data (38 kB)
Individual Animal Teratology Implant Findings Data (49 kB)

3-Month and Chronic Evaluation of the Toxicity (C20302B) of alpha-Pinene (80-56-8) in B6C3F1 Mice via Whole Body Respiratory Exposure

Study Tables

I01 - Animal_Removal_Summary (96 kB)
I02 - Animal_Removals (1 mB)
I03 - Growth_Curve (1 mB)
I03C - Growth_Curve (952 kB)
I04 - Mean_Body_Weight_Summary (613 kB)
I04G - Mean_Body_Weight_Gain (274 kB)
I05 - Clinical_Observations_Summary (825 kB)
PA02 - Neoplastic Lesion Summary with Percent Incidence (858 kB)
PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (1 mB)
PA04 - Neoplasms by Individual Animal (15 mB)
PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (726 kB)
PA06 - Organ Weights Summary (115 kB)
PA07 - Neoplasms by Individual Animal (Systemic Lesions Abridged) (13 mB)
PA08 - Chronic Animals: Statistical Analysis of Neoplastic Lesions (8 mB)
PA09 - Non-Neoplastic Lesions by Individual Animal (18 mB)
PA10 - Statistical Analysis of Non-Neoplastic Lesions (12 mB)
PA11 - Statistical Analysis of Survival Data (202 kB)
PA14 - Individual Animal Pathology Data (25 mB)
PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (1 mB)
PA40C - Survival Curve (432 kB)
PA46s - Summary of Gross Pathology (1 mB)
PA48 - Summary of Internal Concentration (34 kB)

Individual Animal Data

Individual Animal Body Weight Data (431 kB)
Individual Animal Clinical Observations Data (324 kB)
Individual Animal Gross Pathology Data (928 kB)
Individual Animal Histopathology Data (765 kB)
Individual Animal Internal Concentration (22 kB)
Individual Animal Organ Weight Data (7 kB)
Individual Animal Removal Reasons Data (23 kB)