U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Acetaminophen (103-90-2)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID2020006

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Equivocal Evidence, Female, Rats
  • No Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Acetaminophen (103-90-2).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Acetaminophen (103-90-2).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. Acetaminophen (103-90-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-394 Toxicology and Carcinogenesis Studies of Acetaminophen (CASRN 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals using High Throughput Transcriptomics and Benchmark Concentration Modeling Ramaiahgari SC, Auerbach SS, Saddler TO, Rice JR, Dunlap PE, Sipes NS, DeVito MJ, Shah RR, Bushel PR, Merrick BA, Paules RS, Ferguson SS

Toxicological Sciences (2019) DOI: https://doi.org/10.1093/toxsci/kfz065 PMID: 30850835
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0001-0000-6
SRA No. SRP166108; BioProject No. PRJNA497448

Study Data

Protocol

Toxicity and Carcinogenicity Studies

6 - 48-Hour Evaluation of the Toxicity (C55801C) of Acetaminophen (4-Hydroxyacetanilide) (103-90-2) in F344 Rats Exposed via Gavage. NTP Special Study
Individual Animal Data
Clinical Chemistry Reports
6 - 48-Hour Evaluation of the Toxicity (C55801E) of Acetaminophen (4-Hydroxyacetanilide) (103-90-2) in F344/N Rats Exposed via Gavage. NTP Special Study
Individual Animal Data
Clinical Chemistry Reports
6 - 48-Hour Evaluation of the Toxicity (C55801F) of Acetaminophen (4-Hydroxyacetanilide) (103-90-2) in F344 Rats Exposed via Gavage. NTP Special Study
Individual Animal Data
Clinical Chemistry Reports
3-Day Evaluation of the Toxicity (C20325) of Acetaminophen (4-Hydroxyacetanilide) (103-90-2) in F344 Rats Exposed via Gavage. NTP Special Study
Individual Animal Data
Clinical Chemistry Reports
Acute Evaluation of the Toxicity (C55801E) of Acetaminophen (4-Hydroxyacetanilide) (103-90-2) in F344/N Rats Exposed via Gavage
Pathology Tables
Individual Animal Data
Acute Evaluation of the Toxicity (C55801E) of Acetaminophen (4-Hydroxyacetanilide) (103-90-2) in F344/N Rats Exposed via Gavage
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C55801) of Acetaminophen (4-Hydroxyacetanilide) (103-90-2) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C55801) of Acetaminophen (4-Hydroxyacetanilide) (103-90-2) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Acetaminophen (4-Hydroxyacetanilide) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 413793
Summary Data

Other NTP Studies

Screen for Developmental Toxicity in Zebrafish- Study 1
Results

NTP Data Collections