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Caprolactam (105-60-2)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4020240


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Negative, Male, Rats
View
  • Negative, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Negative, Male, Mice
View
  • Negative, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Caprolactam (105-60-2).
Rodent Cytogenetics
CA SCE
  • View
    • Negative (Nonstandard Protocol)
  • View
    • Negative (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Caprolactam (105-60-2).
Micronucleus - Mice
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Caprolactam (105-60-2).
Mammalian Cell Mutagenicity
View
  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Caprolactam (105-60-2).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Caprolactam (105-60-2).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Caprolactam (105-60-2).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. Caprolactam (105-60-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-214 Carcinogenesis Bioassay of Caprolactam (CASRN 105-60-2) in F344 Rats and B6C3F1 Mice (Feed Study)
McFee, A.F., and Lowe, K.W. Caprolactam and benzoin: tests for induction of chromosome aberrations and sister-chromatid exchanges in mouse bone marrow. Mutation Res. Vol. 224 (1989) 347-350
Zeiger, E., and Haworth, S. Tests with a preincubation modification of the Salmonella/microsome assay. In Evaluation of Short-Term Tests for Carcinogens Elsevier/North Holland 187-199
Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
Myhr, B., Bower, L., and Caspary, W. Assays for the induction of gene mutations at the thymine kinase locus in L1578Y mouse lymphoma cells in culture. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland Vol. (1985) 555-568
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
Gulati, D., Sabharwal, P., and Shelby, M. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland 413-426
Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
McFee, A.F., and Lowe, K.W. Caprolactam and benzoin: tests for induction of chromosome aberrations and sister-chromatid exchanges in mouse bone marrow. Mutation Res. Vol. 224 (1989) 347-350

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of Caprolactam (105-60-2) in Male F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of Caprolactam (105-60-2) in Female F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of Caprolactam (105-60-2) in Male B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of Caprolactam (105-60-2) in Female B6C3F1 Mice Exposed via Dosed Feed