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1,3-Butadiene (106-99-0)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID3020203


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Mice studies.
Mice
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  • Clear Evidence, Male, Mice
View
  • Clear Evidence, Female, Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to 1,3-Butadiene (106-99-0).
Rodent Cytogenetics
CA
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 1,3-Butadiene (106-99-0).
Micronucleus - Mice
View
  • Male: Positive (Nonstandard Protocol)
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 1,3-Butadiene (106-99-0).
Mammalian Cell Mutagenicity
View
  • Negative
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to 1,3-Butadiene (106-99-0).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 1,3-Butadiene (106-99-0).
Bacterial Mutagenicity
View
  • Positive

Citation Information


NTP. 1,3-Butadiene (106-99-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-288 Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CASRN 106-99-0) in B6C3F1 Mice (Inhalation Studies)
TR-434 Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CASRN 106-99-0) in B6C3F1 Mice (Inhalation Studies)
Bucher JR, Melnick RL, and Hildebrandt PK. Lack of Carcinogenicity in Mice Exposed Once to High Concentrations of 1,3-Butadiene. J. Nat. Cancer Inst 85: 1866-1867 (1993).
Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
McGregor, D., Brown, A.G., Cattanach, P., Edwards, I., McBride, D., Riach, C., Shepherd, W., and Caspary, W. Responses of the L5178Y mouse lymphoma forward mutation assay: V. Gases and vapors. Environ. Molec. Mutagen. Vol. 17 (1991) 122-129
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C50602B) of 1,3-Butadiene (106-99-0) in F344/N Rats via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,3-Butadiene (106-99-0) in Male B6C3F1 Mice via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,3-Butadiene (106-99-0) in Male B6C3F1 Mice via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,3-Butadiene (106-99-0) in Female B6C3F1 Mice via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,3-Butadiene (106-99-0) in Female B6C3F1 Mice via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity (C50602C) of 1,3-Butadiene (106-99-0) in B6C3F1 Mice via Whole Body Respiratory Exposure

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 1,3-Butadiene (106-99-0) in Micronucleus Study A74454 in B6C3F1 Mice
Genetic Toxicity Evaluation of 1,3-Butadiene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 256166
Summary Data