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Toluene (108-88-3)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Female, Rats
  • No Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Toluene (108-88-3).
Micronucleus - Mice
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Toluene (108-88-3).
Mammalian Cell Mutagenicity
View
  • Equivocal
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Toluene (108-88-3).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Toluene (108-88-3).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. Toluene (108-88-3). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-371 Toxicology and Carcinogenesis Studies of Toluene (CASRN108-88-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity (C07272B) of Toluene (108-88-3) in F344/N Rats via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity (C07272B) of Toluene (108-88-3) in B6C3F1 Mice via Whole Body Respiratory Exposure

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Toluene (Technical) (108-88-3) in Micronucleus Study 044232 in B6C3F1 Mice
Genetic Toxicity Evaluation of Toluene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 132615
Summary Data

Other NTP Studies


2-Week Immunotoxicity Evaluation (IMM86001) of Toluenes (2-4-Diaminotoluene, p-Nitrotoluene, 4-Chloro-o-Phenylenediamine) (TOLUENES) in Female B6C3F1 Mice Exposed via Gavage
ADME/TK Evaluation (S0615) of Toluene (108-88-3) in F344 Rats and B6C3F1 Mice Exposed via Gavage
Data Summary
Screen for Developmental Toxicity in Zebrafish- Study 1
Results