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1,4-Dioxane (123-91-1)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4020533

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Positive, Male, Rats
View
  • Positive, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Positive, Male, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 1,4-Dioxane (123-91-1).
Micronucleus - Mice
View
  • Male: Equivocal
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 1,4-Dioxane (123-91-1).
Mammalian Cell Mutagenicity
View
  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 1,4-Dioxane (123-91-1).
Mammalian Cell Cytogenetics
CA SCE
  • View
    • Weakly Positive
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to 1,4-Dioxane (123-91-1).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 1,4-Dioxane (123-91-1).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative
View
  • Negative

Citation Information

NTP. 1,4-Dioxane (123-91-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-080 Bioassay of 1,4-Dioxane for Possible Carcinogenicity (CASRN 123-91-1)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of 1,4-Dioxane (123-91-1) in Male Osborne-Mendel Rats Exposed via Dosed Water
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,4-Dioxane (123-91-1) in Female Osborne-Mendel Rats Exposed via Dosed Water
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,4-Dioxane (123-91-1) in Male B6C3F1 Mice Exposed via Dosed Water
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,4-Dioxane (123-91-1) in Female B6C3F1 Mice Exposed via Dosed Water
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 1,4-Dioxane (123-91-1) in Micronucleus Study 787385 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 1,4-Dioxane (123-91-1) in Micronucleus Study 906732 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 1,4-Dioxane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 123659
Summary Data
Genetic Toxicity Evaluation of 1,4-Dioxane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 709799
Summary Data
Genetic Toxicity Evaluation of 1,4-Dioxane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 882515
Summary Data

NTP Data Collections