1,4-Dioxane (123-91-1)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4020533
Study Results
Chronic Bioassay Level of Evidence
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Genetic Toxicology
Micronucleus - Mice |
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Mammalian Cell Mutagenicity |
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Mammalian Cell Cytogenetics | |
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CA | SCE |
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Drosophila Germ Cell Mutagenicity |
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SLRL |
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Bacterial Mutagenicity |
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Publications
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
Study Data
Toxicity and Carcinogenicity Studies
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,4-Dioxane (123-91-1) in Male Osborne-Mendel Rats Exposed via Dosed Water
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,4-Dioxane (123-91-1) in Female Osborne-Mendel Rats Exposed via Dosed Water
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,4-Dioxane (123-91-1) in Male B6C3F1 Mice Exposed via Dosed Water
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,4-Dioxane (123-91-1) in Female B6C3F1 Mice Exposed via Dosed Water
Genetic Toxicology Studies
Genetic Toxicity Evaluation of 1,4-Dioxane (123-91-1) in Micronucleus Study 787385 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 1,4-Dioxane (123-91-1) in Micronucleus Study 906732 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 1,4-Dioxane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 123659
Summary Data
- G06 - Ames Summary Data (135 KB)
Genetic Toxicity Evaluation of 1,4-Dioxane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 709799
Summary Data
- G06 - Ames Summary Data (128 KB)
Genetic Toxicity Evaluation of 1,4-Dioxane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 882515
Summary Data
- G06 - Ames Summary Data (62 KB)