COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:

1-Chloro-2-propanol (127-00-4)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Female, Rats
  • No Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 1-Chloro-2-propanol (127-00-4).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 1-Chloro-2-propanol (127-00-4).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to 1-Chloro-2-propanol (127-00-4).
Drosophila Germ Cell Mutagenicity
SLRL RT
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 1-Chloro-2-propanol (127-00-4).
Bacterial Mutagenicity
View
  • Positive
View
  • Positive
View
  • Positive

Citation Information


NTP. 1-Chloro-2-propanol (127-00-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-477 Toxicology and Carcinogenesis Studies of 1-Chloro-2-Propanol (Technical Grade) (CASRN 127-00-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C61983A) of 1-Chloro-2-propanol, Technical (127-00-4) in F344 Rats Exposed via Dosed Water. NTP Special Study
3-Month Evaluation of the Toxicity (C61983A) of 1-Chloro-2-propanol, Technical (127-00-4) in B6C3F1 Mice Exposed via Dosed Water. NTP Special Study
26-Week Evaluation of the Toxicity (C61983D) of 1-Chloro-2-propanol, Technical (127-00-4) in P53(C57BL/6) Mice Exposed via Dosed Water
26-Week Evaluation of the Toxicity (C61983E) of 1-Chloro-2-propanol, Technical (127-00-4) in Tg.AC Mice Exposed via Topical Application
3-Month Evaluation of the Toxicity (C61983A) of 1-Chloro-2-propanol, Technical (127-00-4) in F344/N Rats Exposed via Dosed Water
3-Month Evaluation of the Toxicity (C61983A) of 1-Chloro-2-propanol, Technical (127-00-4) in B6C3F1 Mice Exposed via Dosed Water
Evaluation of the Chronic Toxicity and Carcinogenicity (C61983C) of 1-Chloro-2-propanol, Technical (127-00-4) in F344/N Rats Exposed via Dosed Water
Evaluation of the Chronic Toxicity and Carcinogenicity (C61983C) of 1-Chloro-2-propanol, Technical (127-00-4) in B6C3F1 Mice Exposed via Dosed Water

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 1-Chloro-2-propanol, Technical (127-00-4) in Micronucleus Study A34020 in B6C3F1 Mice
Genetic Toxicity Evaluation of 1-Chloro-2-propanol, Technical (127-00-4) in Micronucleus Study A61208 in Mice
Genetic Toxicity Evaluation of 1-Chloro-2-propanol, Technical in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 111503
Summary Data
Genetic Toxicity Evaluation of 1-Chloro-2-propanol, Technical in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 154127
Summary Data
Genetic Toxicity Evaluation of 1-Chloro-2-propanol, Technical in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 648348
Summary Data

Other NTP Studies


Toxicokinetic Evaluation (S0539) of 1-Chloro-2-propanol (127-00-4) in F344/N Rats and B6C3F1 Mice Exposed via Gavage