1-Chloro-2-propanol (127-00-4)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID5020285
Study Results
Chronic Bioassay Level of Evidence
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| Mice | |
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Genetic Toxicology
| Micronucleus - Mice |
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| Mammalian Cell Cytogenetics | |
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| CA | SCE |
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| Drosophila Germ Cell Mutagenicity | |
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| SLRL | RT |
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| Bacterial Mutagenicity |
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Publications
TR-477
Toxicology and Carcinogenesis Studies of 1-Chloro-2-Propanol (Technical Grade) (CASRN 127-00-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
Study Data
Toxicity and Carcinogenicity Studies
3-Month Evaluation of the Toxicity (C61983A) of 1-Chloro-2-propanol, Technical (127-00-4) in F344 Rats Exposed via Dosed Water. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Clinical Chemistry Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C61983A) of 1-Chloro-2-propanol, Technical (127-00-4) in B6C3F1 Mice Exposed via Dosed Water. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
26-Week Evaluation of the Toxicity (C61983D) of 1-Chloro-2-propanol, Technical (127-00-4) in P53(C57BL/6) Mice Exposed via Dosed Water
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
26-Week Evaluation of the Toxicity (C61983E) of 1-Chloro-2-propanol, Technical (127-00-4) in Tg.AC Mice Exposed via Topical Application
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
3-Month Evaluation of the Toxicity (C61983A) of 1-Chloro-2-propanol, Technical (127-00-4) in F344/N Rats Exposed via Dosed Water
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C61983A) of 1-Chloro-2-propanol, Technical (127-00-4) in B6C3F1 Mice Exposed via Dosed Water
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C61983C) of 1-Chloro-2-propanol, Technical (127-00-4) in F344/N Rats Exposed via Dosed Water
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C61983C) of 1-Chloro-2-propanol, Technical (127-00-4) in B6C3F1 Mice Exposed via Dosed Water
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Genetic Toxicology Studies
Genetic Toxicity Evaluation of 1-Chloro-2-propanol, Technical (127-00-4) in Micronucleus Study A34020 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 1-Chloro-2-propanol, Technical (127-00-4) in Micronucleus Study A61208 in Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 1-Chloro-2-propanol, Technical in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 111503
Summary Data
- G06 - Ames Summary Data (107 KB)
Genetic Toxicity Evaluation of 1-Chloro-2-propanol, Technical in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 154127
Summary Data
- G06 - Ames Summary Data (112 KB)
Genetic Toxicity Evaluation of 1-Chloro-2-propanol, Technical in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 648348
Summary Data
- G06 - Ames Summary Data (95 KB)
Other NTP Studies
Toxicokinetic Evaluation (S0539) of 1-chloro-2-propanol (DTXSID5020285) in Rat and Mouse
Data
- Annotated Group Parameters (17 kB)
- Annotated Individual Animal Data (125 kB)
- Original Data (38 kB)
- Summary Data - Mouse (186 kB)
- Summary Data - Rat (147 kB)