Tricresyl phosphate (1330-78-5)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4021391
Study Results
Chronic Bioassay Level of Evidence
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Genetic Toxicology
Mammalian Cell Cytogenetics | |
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Publications
TR-433
Toxicology and Carcinogenesis Studies of Tricresyl Phosphate (CASRN 1330-78-5) in F344/N Rats and B6C3F1 Mice (Gavage and Feed Studies)
NIEHS-06
NIEHS Report on the In Vivo Repeat Dose Biological Potency Study of Tricresyl Phosphate (CASRN 1330-78-5) in Male Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Ryan KR, Sirenko O, Parham F, Hsieh JH, Cromwell EF, Tice RR, Behl M. Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high-throughput screen for developmental neurotoxicity or neurotoxicity. Neurotoxicology. 2016 Mar;53:271-281. doi: 10.1016/j.neuro.2016.02.003. Epub 2016 Feb 4. PMID: 26854185
Behl M, Rice JR, Smith MV, Co CA, Bridge MF, Hsieh JH, Freedman JH, Boyd WA. Editor's Highlight: Comparative Toxicity of Organophosphate Flame Retardants and Polybrominated Diphenyl Ethers to Caenorhabditis elegans. Toxicol Sci. 2016 Dec;154(2):241-252. doi: 10.1093/toxsci/kfw162. Epub 2016 Aug 26. PMID: 27566445
Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR. In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. Toxicol Appl Pharmacol. 2017 May 1;322:60-74. doi: 10.1016/j.taap.2017.02.020. Epub 2017 Mar 1. PMID: 28259702
Nyffeler J, Dolde X, Krebs A, Pinto-Gil K, Pastor M, Behl M, Waldmann T, Leist M. Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library. Arch Toxicol. 2017 Nov;91(11):3613-3632. doi: 10.1007/s00204-017-1977-y. Epub 2017 May 5. PMID: 28477266
Sirenko O, Parham F, Dea S, Sodhi N, Biesmans S, Mora-Castilla S, Ryan K, Behl M, Chandy G, Crittenden C, Vargas-Hurlston S, Guicherit O, Gordon R, Zanella F, Carromeu C. Functional and Mechanistic Neurotoxicity Profiling Using Human iPSC-Derived Neural 3D Cultures. Toxicol Sci. 2019 Jan 1;167(1):58-76. doi: 10.1093/toxsci/kfy218. PMID: 30169818
Alzualde A, Behl M, Sipes NS, Hsieh JH, Alday A, Tice RR, Paules RS, Muriana A, Quevedo C. Toxicity profiling of flame retardants in zebrafish embryos using a battery of assays for developmental toxicity, neurotoxicity, cardiotoxicity and hepatotoxicity toward human relevance. Neurotoxicol Teratol. 2018 Nov-Dec;70:40-50. doi: 10.1016/j.ntt.2018.10.002. Epub 2018 Oct 9. PMID: 30312655
Quevedo C, Behl M, Ryan K, Paules RS, Alday A, Muriana A, Alzualde A. Detection and Prioritization of Developmentally Neurotoxic and/or Neurotoxic Compounds Using Zebrafish. Toxicol Sci. 2019 Mar 1;168(1):225-240. doi: 10.1093/toxsci/kfy291. PMID: 30521027
Zhang S, Ireland D, Sipes NS, Behl M, Collins ES. Screening for neurotoxic potential of 15 flame retardants using freshwater planarians. Neurotoxicol Teratol. 2019 May-Jun;73:54-66. doi: 10.1016/j.ntt.2019.03.003. Epub 2019 Mar 31. PMID: 30943442
Hogberg HT, de Cássia da Silveira E Sá R, Kleensang A, Bouhifd M, Cemiloglu Ulker O, Smirnova L, Behl M, Maertens A, Zhao L, Hartung T. Organophosphorus flame retardants are developmental neurotoxicants in a rat primary brainsphere in vitro model. Arch Toxicol. 2021 Jan;95(1):207-228. doi: 10.1007/s00204-020-02903-2. Epub 2020 Oct 19. PMID: 33078273
Klose J, Pahl M, Bartmann K, Bendt F, Blum J, Dolde X, Förster N, Holzer AK, Hübenthal U, Keßel HE, Koch K, Masjosthusmann S, Schneider S, Stürzl LC, Woeste S, Rossi A, Covaci A, Behl M, Leist M, Tigges J, Fritsche E. Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery. Cell Biol Toxicol. 2022 Oct;38(5):781-807. doi: 10.1007/s10565-021-09603-2. Epub 2021 May 10. PMID: 33969458
Emond C, DeVito MJ, Birnbaum LS. A PBPK model describing the pharmacokinetics of γ-HBCD exposure in mice. Toxicol Appl Pharmacol. 2021 Oct 1;428:115678. doi: 10.1016/j.taap.2021.115678. Epub 2021 Aug 11. PMID: 34390738
Jarema KA, Hunter DL, Shaffer RM, Behl M, Padilla S. Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish. Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):194-209. doi: 10.1016/j.ntt.2015.08.010. Epub 2015 Sep 5. PMID: 26348672
Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES 3rd, Jarema KA, Padilla S, Tice RR. Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):181-93. doi: 10.1016/j.ntt.2015.09.003. Epub 2015 Sep 18. PMID: 26386178
Study Data
Toxicity and Carcinogenicity Studies
5-Day Evaluation of the Toxicity (C10277) of Tricresyl Phosphate (TCP) (1330-78-5) on Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
- I04 - Mean Body Weight Summary (52 kB)
- I05 - Clinical Observations Summary (32 kB)
- PA06 - Organ Weights Summary (46 kB)
- PA41 - Clinical Chemistry Summary (133 kB)
- R07 - Hormone Summary (37 kB)
Individual Animal Data
3-Month Evaluation of the Toxicity (C61041B) of Tricresyl Phosphate (1330-78-5) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C61041B) of Tricresyl Phosphate (1330-78-5) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C61041B) of Tricresyl Phosphate (1330-78-5) in F344/N Rats Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C61041B) of Tricresyl Phosphate (1330-78-5) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Neoplastic
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Neoplastic
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Tricresyl Phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 197511
Genetic Toxicity Evaluation of Tricresyl Phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 618410
Other NTP Studies
Screen for Developmental Toxicity in Zebrafish- Study 1
Results
- Zebrafish 2,3,7,8-Tetrachlorodibenzo-p-dioxin CASRN 1746-01-6 (28 kB)
- Zebrafish 1-Ethyl-3-methylimidazolium diethylphosphate CASRN 848641-69-0 (21 kB)
- Zebrafish 1-Methyl-4-phenylpyridinium iodide CASRN 36913-39-0 (21 kB)
- Zebrafish 2,2',4,4',5,5'-Hexabromodiphenyl ether (BDE-153) CASRN 68631-49-2 (21 kB)
- Zebrafish 2,2',4,4',5-Pentabromodiphenyl ether (BDE-99) CASRN 60348-60-9 (22 kB)
- Zebrafish 2,2',4,4'-Tetrabromodiphenyl ether CASRN 5436-43-1 (28 kB)
- Zebrafish 2-Ethylhexyl diphenyl phosphate (EHDP) CASRN 1241-94-7 (28 kB)
- Zebrafish 2-Ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB) CASRN 183658-27-7 (21 kB)
- Zebrafish 2-Methoxyethanol CASRN 109-86-4 (22 kB)
- Zebrafish 3,3'-Iminodipropionitrile CASRN 111-94-4 (22 kB)
- Zebrafish 3,3’,5,5’-Tetrabromobisphenol A CASRN 79-94-7 (28 kB)
- Zebrafish 4-H-Cyclopenta(d,e,f)phenanthrene CASRN 203-64-5 (28 kB)
- Zebrafish 5-Fluorouracil CASRN 51-21-8 (21 kB)
- Zebrafish 5-nitro-2-furaldehyde semicarbazone CASRN 59-87-0 (23 kB)
- Zebrafish 6-Hydroxydopamine hydrochloride CASRN 28094-15-7 (21 kB)
- Zebrafish 6-Propyl-2-thiouracil CASRN 51-52-5 (21 kB)
- Zebrafish Acenaphthene CASRN 83-32-9 (28 kB)
- Zebrafish Acenaphthylene CASRN 208-96-8 (28 kB)
- Zebrafish Acetaminophen (4-hydroxyacetanilide) CASRN 103-90-2 (22 kB)
- Zebrafish Acetic acid, manganese (2+) salt CASRN 638-38-0 (22 kB)
- Zebrafish Acetylsalicylic acid CASRN 50-78-2 (21 kB)
- Zebrafish Acrylamide CASRN 79-06-1 (22 kB)
- Zebrafish Aldicarb CASRN 116-06-3 (28 kB)
- Zebrafish Amoxicillin CASRN 26787-78-0 (21 kB)
- Zebrafish Anthracene CASRN 120-12-7 (21 kB)
- Zebrafish Auramine O CASRN 2465-27-2 (28 kB)
- Zebrafish Benz(a)anthracene CASRN 56-55-3 (27 kB)
- Zebrafish Benzo(a)pyrene CASRN 50-32-8 (27 kB)
- Zebrafish Benzo(b)fluoranthene CASRN 205-99-2 (28 kB)
- Zebrafish Benzo(e)pyrene CASRN 192-97-2 (28 kB)
- Zebrafish Benzo(k)fluoranthene CASRN 207-08-9 (27 kB)
- Zebrafish Benzog,h,i perylene CASRN 191-24-2 (21 kB)
- Zebrafish Berberine chloride CASRN 633-65-8 (21 kB)
- Zebrafish Bis(2-ethylhexyl) 3,4,5,6- tetrabromophthalate (TBPH) CASRN 26040-51-7 (21 kB)
- Zebrafish Bis(tributyltin)oxide CASRN 56-35-9 (28 kB)
- Zebrafish Bisphenol A CASRN 80-05-7 (27 kB)
- Zebrafish Bisphenol AF CASRN 1478-61-1 (28 kB)
- Zebrafish Bisphenol S CASRN 80-09-1 (21 kB)
- Zebrafish Captan CASRN 133-06-2 (27 kB)
- Zebrafish Carbamic acid, butyl-, 3-iodo-2-propynyl ester CASRN 55406-53-6 (28 kB)
- Zebrafish Carbaryl CASRN 63-25-2 (27 kB)
- Zebrafish Chlorpyrifos (Dursban) CASRN 2921-88-2 (27 kB)
- Zebrafish Chrysene CASRN 218-01-9 (21 kB)
- Zebrafish Colchicine CASRN 64-86-8 (27 kB)
- Zebrafish D-Glucitol CASRN 50-70-4 (21 kB)
- Zebrafish Deltamethrin CASRN 52918-63-5 (45 kB)
- Zebrafish Di(2-ethylhexyl) phthalate CASRN 117-81-7 (22 kB)
- Zebrafish Diazepam CASRN 439-14-5 (28 kB)
- Zebrafish Dibenz a,c anthracene CASRN 215-58-7 (21 kB)
- Zebrafish Dibenz(a,h)anthracene CASRN 53-70-3 (27 kB)
- Zebrafish Dichlorodiphenyltrichloroethane (DDT) CASRN 50-29-3 (28 kB)
- Zebrafish Dieldrin CASRN 60-57-1 (27 kB)
- Zebrafish Diethylstilbestrol CASRN 56-53-1 (28 kB)
- Zebrafish Estradiol CASRN 50-28-2 (28 kB)
- Zebrafish Firemaster 550 CASRN 860302-33-6 (28 kB)
- Zebrafish Fluorene CASRN 86-73-7 (28 kB)
- Zebrafish Heptachlor CASRN 76-44-8 (28 kB)
- Zebrafish Hexachlorophene CASRN 70-30-4 (28 kB)
- Zebrafish Hydroxyurea CASRN 127-07-1 (21 kB)
- Zebrafish Isodecyl diphenyl phosphate CASRN 29761-21-5 (27 kB)
- Zebrafish L-Ascorbic acid CASRN 50-81-7 (21 kB)
- Zebrafish Lead (II) acetate trihydrate CASRN 6080-56-4 (27 kB)
- Zebrafish Lindane CASRN 58-89-9 (27 kB)
- Zebrafish MPEP CASRN 95737-68-1 (29 kB)
- Zebrafish Manganese, tricarbonyl (1,2,3,4,5-.eta.)-1-methyl-2,4-cyclopentadien-1-yl- CASRN 12108-13-3 (21 kB)
- Zebrafish Methyl mercuric (II) chloride CASRN 115-09-3 (46 kB)
- Zebrafish Naphthalene CASRN 91-20-3 (27 kB)
- Zebrafish Parathion CASRN 56-38-2 (28 kB)
- Zebrafish Permethrin CASRN 52645-53-1 (27 kB)
- Zebrafish Phenanthrene CASRN 85-01-8 (28 kB)
- Zebrafish Phenobarbital CASRN 50-06-6 (21 kB)
- Zebrafish Phenobarbital sodium salt CASRN 57-30-7 (27 kB)
- Zebrafish Phenol, isopropylated, phosphate (3 to1) CASRN 68937-41-7 (28 kB)
- Zebrafish Pyrene CASRN 129-00-0 (27 kB)
- Zebrafish Rotenone CASRN 83-79-4 (28 kB)
- Zebrafish Saccharin Sodium Salt hydrate CASRN 82385-42-0 (33 kB)
- Zebrafish Tebuconazole CASRN 107534-96-3 (28 kB)
- Zebrafish Tetraethylthiuram disulfide CASRN 97-77-8 (28 kB)
- Zebrafish Thalidomide CASRN 50-35-1 (27 kB)
- Zebrafish Toluene CASRN 108-88-3 (21 kB)
- Zebrafish Tricresyl phosphate CASRN 1330-78-5 (28 kB)
- Zebrafish Triphenyl phosphate CASRN 115-86-6 (46 kB)
- Zebrafish Tris(2-Chloroethyl) Phosphate CASRN 115-96-8 (21 kB)
- Zebrafish Valinomycin CASRN 2001-95-8 (29 kB)
- Zebrafish Valproic acid sodium salt CASRN 1069-66-5 (27 kB)
- Zebrafish n-Hexane CASRN 110-54-3 (27 kB)
- Zebrafish tert-Butylphenyl diphenyl phosphate CASRN 56803-37-3 (29 kB)
- Zebrafish tris(Chloropropyl) phosphate, TCPP CASRN 13674-84-5 (27 kB)