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Tris(Chloropropyl)phosphate (13674-84-5)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID201016652

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Rats study conclusions related to Tris(Chloropropyl)phosphate (13674-84-5).
Micronucleus - Rats
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Tris(Chloropropyl)phosphate (13674-84-5).
Micronucleus - Mice
View
  • Male: Positive
    Female: Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Tris(Chloropropyl)phosphate (13674-84-5).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative

Citation Information

NTP. Tris(Chloropropyl)phosphate (13674-84-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-602 Toxicity Studies of tris(2-Chloroisopropyl)phosphate Administered via Dosed Feed to Harlan Sprague-Dawley Rats and B6C3F1/N Mice
DART-01 Prenatal Developmental Toxicity Studies of Tris(chloropropyl) Phosphate in Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Gavage Studies)
Collins BJ, Slade D, Ryan K, Mathias R, Shan A, Algaier J, Aillon K, Waidyanatha S.J. Development and Validation of an Analytical Method to Quantitate Tris(chloroisopropyl)phosphate in Rat and Mouse Plasma using Gas Chromatography with Flame Photometric Detection. Anal Toxicol. 2019 Jan 1;43(1):36-44. doi: 10.1093/jat/bky048. PMID: 30060005
Sirenko O, Parham F, Dea S, Sodhi N, Biesmans S, Mora-Castilla S, Ryan K, Behl M, Chandy G, Crittenden C, Vargas-Hurlston S, Guicherit O, Gordon R, Zanella F, Carromeu C. Functional and Mechanistic Neurotoxicity Profiling Using Human iPSC-Derived Neural 3D Cultures. Toxicol Sci. 2019 Jan 1;167(1):58-76. doi: 10.1093/toxsci/kfy218. PMID: 30169818
Quevedo C, Behl M, Ryan K, Paules RS, Alday A, Muriana A, Alzualde A. Detection and Prioritization of Developmentally Neurotoxic and/or Neurotoxic Compounds Using Zebrafish. Toxicol Sci. 2019 Mar 1;168(1):225-240. doi: 10.1093/toxsci/kfy291. PMID: 30521027
Zhang S, Ireland D, Sipes NS, Behl M, Collins ES. Screening for neurotoxic potential of 15 flame retardants using freshwater planarians. Neurotoxicol Teratol. 2019 May-Jun;73:54-66. doi: 10.1016/j.ntt.2019.03.003. Epub 2019 Mar 31. PMID: 30943442
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito


CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005
Plasma concentrations of tris(1-chloro-2-propyl) phosphate and a metabolite bis(2-chloroisopropyl) 1-carboxyethyl phosphate in Sprague-Dawley rats and B6C3F1/N mice from a chronic study of tris(chloropropyl) phosphate via feed BJ Collins, D Slade, K Aillon, M Stout, L Betz, S Waidyanatha, K Ryan
Toxicology Reports (2022) DOI: https://doi.org/10.1016/j.toxrep.2022.03.025

DOI: https://doi.org/10.22427/NTP-DATA-002-03220-0026-0000-7

Study Data

Protocol

Toxicity and Carcinogenicity Studies

3-Month (with Perinatal Exposure) Evaluation of the Toxicity (C20712-01) of tris(2-Chloroisopropyl)phosphate (13674-84-5) in Harlan Sprague-Dawley Rats Exposed via Dosed Feed
Study Tables
Individual Animal Data
5-day study (C20263) of Tris(Chloropropyl)phosphate (13674-84-5) delivered via Gavage in HSD Rat
Study Tables
Individual Animal Data
3-Month Evaluation of the Toxicity (C20712-02) of tris(Chloropropyl)phosphate (13674-84-5) in B6C3F1/N Mice Exposed via Dosed Feed
Study Tables
Individual Animal Data
Evaluation of the Chronic (with Perinatal Exposure) Toxicity and Carcinogenicity (C20712-03) of Tris(Chloropropyl) phosphate (1367-84-5) in Harlan Sprague Dawley Rats Exposed via Dosed Feed
Study Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C20712-04) of Tris(Chloropropyl) phosphate (1367-84-5) in B6C3F1 Mice Exposed via Dosed Feed
Study Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of tris(Chloropropyl)phosphate (13674-84-5) in Micronucleus Study G20263 in Harlan Sprague-Dawley Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of tris(Chloropropyl)phosphate (13674-84-5) in Micronucleus Study G20263B in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of tris(Chloropropyl)phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 815918
Summary Data
Genetic Toxicity Evaluation of tris(Chloropropyl)phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G20263C
Summary Data

Other NTP Studies

Evaluation of the Prenatal Development Toxicity (R20263B) of tris(Chloropropyl)phosphate (TCPP) (13674-84-5) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
Individual Animal Data
Evaluation of the Prenatal Developmental Toxicity Dose Range Finding Study (R20263) of tris(Chloropropyl)phosphate (TCPP) (13674-84-5) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
Individual Animal Data
Screen for Developmental Toxicity in Zebrafish- Study 1
Results

NTP Data Collections