Tris(Chloropropyl)phosphate (13674-84-5)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID201016652
Publications
DART-01
Prenatal Developmental Toxicity Studies of Tris(chloropropyl) Phosphate in Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Gavage Studies)
Collins BJ, Slade D, Ryan K, Mathias R, Shan A, Algaier J, Aillon K, Waidyanatha S.J. Development and Validation of an Analytical Method to Quantitate Tris(chloroisopropyl)phosphate in Rat and Mouse Plasma using Gas Chromatography with Flame Photometric Detection. Anal Toxicol. 2019 Jan 1;43(1):36-44. doi: 10.1093/jat/bky048. PMID: 30060005
Sirenko O, Parham F, Dea S, Sodhi N, Biesmans S, Mora-Castilla S, Ryan K, Behl M, Chandy G, Crittenden C, Vargas-Hurlston S, Guicherit O, Gordon R, Zanella F, Carromeu C. Functional and Mechanistic Neurotoxicity Profiling Using Human iPSC-Derived Neural 3D Cultures. Toxicol Sci. 2019 Jan 1;167(1):58-76. doi: 10.1093/toxsci/kfy218. PMID: 30169818
Quevedo C, Behl M, Ryan K, Paules RS, Alday A, Muriana A, Alzualde A. Detection and Prioritization of Developmentally Neurotoxic and/or Neurotoxic Compounds Using Zebrafish. Toxicol Sci. 2019 Mar 1;168(1):225-240. doi: 10.1093/toxsci/kfy291. PMID: 30521027
Zhang S, Ireland D, Sipes NS, Behl M, Collins ES. Screening for neurotoxic potential of 15 flame retardants using freshwater planarians. Neurotoxicol Teratol. 2019 May-Jun;73:54-66. doi: 10.1016/j.ntt.2019.03.003. Epub 2019 Mar 31. PMID: 30943442
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes
William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005
Plasma concentrations of tris(1-chloro-2-propyl) phosphate and a metabolite bis(2-chloroisopropyl) 1-carboxyethyl phosphate in Sprague-Dawley rats and B6C3F1/N mice from a chronic study of tris(chloropropyl) phosphate via feed
BJ Collins, D Slade, K Aillon, M Stout, L Betz, S Waidyanatha, K Ryan
Toxicology Reports (2022) DOI: https://doi.org/10.1016/j.toxrep.2022.03.025
DOI: https://doi.org/10.22427/NTP-DATA-002-03220-0026-0000-7
Toxicology Reports (2022) DOI: https://doi.org/10.1016/j.toxrep.2022.03.025
DOI: https://doi.org/10.22427/NTP-DATA-002-03220-0026-0000-7
Study Data
Toxicity and Carcinogenicity Studies
5-day study (C20263) of Tris(Chloropropyl)phosphate (13674-84-5) delivered via Gavage in HSD Rat
Study Tables
- I01 - Animal Removal Summary (34 kB)
- I03 - Growth Curve (294 kB)
- I03C - Growth Curve (316 kB)
- I04 - Mean Body Weight Summary (65 kB)
- I04G - Mean Body Weight Gain (53 kB)
- I05 - Clinical Observations Summary (86 kB)
- PA06 - Organ Weights Summary (56 kB)
Individual Animal Data
Genetic Toxicology Studies
Genetic Toxicity Evaluation of tris(Chloropropyl)phosphate (13674-84-5) in Micronucleus Study G20263 in Harlan Sprague-Dawley Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of tris(Chloropropyl)phosphate (13674-84-5) in Micronucleus Study G20263B in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of tris(Chloropropyl)phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 815918
Summary Data
- 815918 G06 Ames Summary Data (197 KB)
Genetic Toxicity Evaluation of tris(Chloropropyl)phosphate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G20263C
Summary Data
- G06 - Ames Summary Data (83 KB)
Other NTP Studies
Evaluation of the Prenatal Development Toxicity (R20263B) of tris(Chloropropyl)phosphate (TCPP) (13674-84-5) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
- I01 - Animal Removal Summary (31 kB)
- I03 - Growth Curve (50 kB)
- I04 - Mean Body Weights and Survival (104 kB)
- I04G - Mean Body Weight Gain (52 kB)
- I05 - Clinical Observations Summary (93 kB)
- I06 - Mean Feed Consumption (59 kB)
- PA06 - Organ Weights Summary (41 kB)
- PA46 - Gross Pathology Summary (79 kB)
- R09 - Uterine Content Summary (77 kB)
- R10 - Fetal Defects (220 kB)
- R11 - Fetal Defect Summary (100 kB)
- R13 - Fetal Defect Cross Reference Summary (157 kB)
Individual Animal Data
- Individual Animal Body Weight Data (96 kB)
- Individual Animal Clinical Observations Data (130 kB)
- Individual Animal Consumption Data (33 kB)
- Individual Animal Gross Pathology Data (15 kB)
- Individual Animal Organ Weight Data (19 kB)
- Individual Animal Removal Reasons (15 kB)
- Individual Animal Teratology Dam Data (22 kB)
- Individual Animal Teratology Implant Data (423 kB)
Evaluation of the Prenatal Developmental Toxicity Dose Range Finding Study (R20263) of tris(Chloropropyl)phosphate (TCPP) (13674-84-5) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
- I01 - Animal Removal Summary (38 kB)
- I03 - Growth Curve (51 kB)
- I04 - Mean Body Weights and Survival (104 kB)
- I04G - Mean Body Weight Gain (52 kB)
- I05 - Clinical Observations Summary (117 kB)
- I06 - Mean Feed Consumption (60 kB)
- PA46 - Gross Pathology Summary (96 kB)
- R09 - Uterine Content Summary (77 kB)
- R10 - Fetal Defects (37 kB)
- R11 - Fetal Defect Summary (43 kB)
- R13 - Fetal Defect Cross Reference Summary (37 kB)
Individual Animal Data
- Individual Animal Body Weight Data (38 kB)
- Individual Animal Clinical Observations Data (52 kB)
- Individual Animal Consumption Data (19 kB)
- Individual Animal Gross Pathology Data (11 kB)
- Individual Animal Removal Reasons (12 kB)
- Individual Animal Teratology Dam Data (12 kB)
- Individual Animal Teratology Implant Data (35 kB)
Screen for Developmental Toxicity in Zebrafish- Study 1
Results
- Zebrafish 2,3,7,8-Tetrachlorodibenzo-p-dioxin CASRN 1746-01-6 (28 kB)
- Zebrafish 1-Ethyl-3-methylimidazolium diethylphosphate CASRN 848641-69-0 (21 kB)
- Zebrafish 1-Methyl-4-phenylpyridinium iodide CASRN 36913-39-0 (21 kB)
- Zebrafish 2,2',4,4',5,5'-Hexabromodiphenyl ether (BDE-153) CASRN 68631-49-2 (21 kB)
- Zebrafish 2,2',4,4',5-Pentabromodiphenyl ether (BDE-99) CASRN 60348-60-9 (22 kB)
- Zebrafish 2,2',4,4'-Tetrabromodiphenyl ether CASRN 5436-43-1 (28 kB)
- Zebrafish 2-Ethylhexyl diphenyl phosphate (EHDP) CASRN 1241-94-7 (28 kB)
- Zebrafish 2-Ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB) CASRN 183658-27-7 (21 kB)
- Zebrafish 2-Methoxyethanol CASRN 109-86-4 (22 kB)
- Zebrafish 3,3'-Iminodipropionitrile CASRN 111-94-4 (22 kB)
- Zebrafish 3,3’,5,5’-Tetrabromobisphenol A CASRN 79-94-7 (28 kB)
- Zebrafish 4-H-Cyclopenta(d,e,f)phenanthrene CASRN 203-64-5 (28 kB)
- Zebrafish 5-Fluorouracil CASRN 51-21-8 (21 kB)
- Zebrafish 5-nitro-2-furaldehyde semicarbazone CASRN 59-87-0 (23 kB)
- Zebrafish 6-Hydroxydopamine hydrochloride CASRN 28094-15-7 (21 kB)
- Zebrafish 6-Propyl-2-thiouracil CASRN 51-52-5 (21 kB)
- Zebrafish Acenaphthene CASRN 83-32-9 (28 kB)
- Zebrafish Acenaphthylene CASRN 208-96-8 (28 kB)
- Zebrafish Acetaminophen (4-hydroxyacetanilide) CASRN 103-90-2 (22 kB)
- Zebrafish Acetic acid, manganese (2+) salt CASRN 638-38-0 (22 kB)
- Zebrafish Acetylsalicylic acid CASRN 50-78-2 (21 kB)
- Zebrafish Acrylamide CASRN 79-06-1 (22 kB)
- Zebrafish Aldicarb CASRN 116-06-3 (28 kB)
- Zebrafish Amoxicillin CASRN 26787-78-0 (21 kB)
- Zebrafish Anthracene CASRN 120-12-7 (21 kB)
- Zebrafish Auramine O CASRN 2465-27-2 (28 kB)
- Zebrafish Benz(a)anthracene CASRN 56-55-3 (27 kB)
- Zebrafish Benzo(a)pyrene CASRN 50-32-8 (27 kB)
- Zebrafish Benzo(b)fluoranthene CASRN 205-99-2 (28 kB)
- Zebrafish Benzo(e)pyrene CASRN 192-97-2 (28 kB)
- Zebrafish Benzo(k)fluoranthene CASRN 207-08-9 (27 kB)
- Zebrafish Benzog,h,i perylene CASRN 191-24-2 (21 kB)
- Zebrafish Berberine chloride CASRN 633-65-8 (21 kB)
- Zebrafish Bis(2-ethylhexyl) 3,4,5,6- tetrabromophthalate (TBPH) CASRN 26040-51-7 (21 kB)
- Zebrafish Bis(tributyltin)oxide CASRN 56-35-9 (28 kB)
- Zebrafish Bisphenol A CASRN 80-05-7 (27 kB)
- Zebrafish Bisphenol AF CASRN 1478-61-1 (28 kB)
- Zebrafish Bisphenol S CASRN 80-09-1 (21 kB)
- Zebrafish Captan CASRN 133-06-2 (27 kB)
- Zebrafish Carbamic acid, butyl-, 3-iodo-2-propynyl ester CASRN 55406-53-6 (28 kB)
- Zebrafish Carbaryl CASRN 63-25-2 (27 kB)
- Zebrafish Chlorpyrifos (Dursban) CASRN 2921-88-2 (27 kB)
- Zebrafish Chrysene CASRN 218-01-9 (21 kB)
- Zebrafish Colchicine CASRN 64-86-8 (27 kB)
- Zebrafish D-Glucitol CASRN 50-70-4 (21 kB)
- Zebrafish Deltamethrin CASRN 52918-63-5 (45 kB)
- Zebrafish Di(2-ethylhexyl) phthalate CASRN 117-81-7 (22 kB)
- Zebrafish Diazepam CASRN 439-14-5 (28 kB)
- Zebrafish Dibenz a,c anthracene CASRN 215-58-7 (21 kB)
- Zebrafish Dibenz(a,h)anthracene CASRN 53-70-3 (27 kB)
- Zebrafish Dichlorodiphenyltrichloroethane (DDT) CASRN 50-29-3 (28 kB)
- Zebrafish Dieldrin CASRN 60-57-1 (27 kB)
- Zebrafish Diethylstilbestrol CASRN 56-53-1 (28 kB)
- Zebrafish Estradiol CASRN 50-28-2 (28 kB)
- Zebrafish Firemaster 550 CASRN 860302-33-6 (28 kB)
- Zebrafish Fluorene CASRN 86-73-7 (28 kB)
- Zebrafish Heptachlor CASRN 76-44-8 (28 kB)
- Zebrafish Hexachlorophene CASRN 70-30-4 (28 kB)
- Zebrafish Hydroxyurea CASRN 127-07-1 (21 kB)
- Zebrafish Isodecyl diphenyl phosphate CASRN 29761-21-5 (27 kB)
- Zebrafish L-Ascorbic acid CASRN 50-81-7 (21 kB)
- Zebrafish Lead (II) acetate trihydrate CASRN 6080-56-4 (27 kB)
- Zebrafish Lindane CASRN 58-89-9 (27 kB)
- Zebrafish MPEP CASRN 95737-68-1 (29 kB)
- Zebrafish Manganese, tricarbonyl (1,2,3,4,5-.eta.)-1-methyl-2,4-cyclopentadien-1-yl- CASRN 12108-13-3 (21 kB)
- Zebrafish Methyl mercuric (II) chloride CASRN 115-09-3 (46 kB)
- Zebrafish Naphthalene CASRN 91-20-3 (27 kB)
- Zebrafish Parathion CASRN 56-38-2 (28 kB)
- Zebrafish Permethrin CASRN 52645-53-1 (27 kB)
- Zebrafish Phenanthrene CASRN 85-01-8 (28 kB)
- Zebrafish Phenobarbital CASRN 50-06-6 (21 kB)
- Zebrafish Phenobarbital sodium salt CASRN 57-30-7 (27 kB)
- Zebrafish Phenol, isopropylated, phosphate (3 to1) CASRN 68937-41-7 (28 kB)
- Zebrafish Pyrene CASRN 129-00-0 (27 kB)
- Zebrafish Rotenone CASRN 83-79-4 (28 kB)
- Zebrafish Saccharin Sodium Salt hydrate CASRN 82385-42-0 (33 kB)
- Zebrafish Tebuconazole CASRN 107534-96-3 (28 kB)
- Zebrafish Tetraethylthiuram disulfide CASRN 97-77-8 (28 kB)
- Zebrafish Thalidomide CASRN 50-35-1 (27 kB)
- Zebrafish Toluene CASRN 108-88-3 (21 kB)
- Zebrafish Tricresyl phosphate CASRN 1330-78-5 (28 kB)
- Zebrafish Triphenyl phosphate CASRN 115-86-6 (46 kB)
- Zebrafish Tris(2-Chloroethyl) Phosphate CASRN 115-96-8 (21 kB)
- Zebrafish Valinomycin CASRN 2001-95-8 (29 kB)
- Zebrafish Valproic acid sodium salt CASRN 1069-66-5 (27 kB)
- Zebrafish n-Hexane CASRN 110-54-3 (27 kB)
- Zebrafish tert-Butylphenyl diphenyl phosphate CASRN 56803-37-3 (29 kB)
- Zebrafish tris(Chloropropyl) phosphate, TCPP CASRN 13674-84-5 (27 kB)