Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) (21850-44-2)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID3032129
Publications
TOX-85
Toxicity Studies of Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) (CASRN 21850-44-2) Administered by Gavage to F344/NTac Rats and B6C3F1/N Mice
Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Transcriptomic data from the rat liver after five days of exposure to legacy or emerging brominated flame retardants. Data Brief. 2020 Aug 5;32:106136. doi: 10.1016/j.dib.2020.106136. eCollection 2020 Oct. PMID: 32904430
Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat
Keith R Shockley, Michelle C Cora, David E Malarkey, Daven Jackson-Humbles, Molly Vallant, Brad J Collins, Esra Mutlu, Veronica G Robinson, Surayma Waidyanatha, Amy Zmarowski, Nicholas Machesky, Jamie Richey, Sam Harbo, Emily Cheng, Kristin Patton, Barney Sparrow, June K Dunnick
Toxicology Letters (2020) DOI: https://doi.org/10.1016/j.toxlet.2020.07.016 PMID: 32679240
GEO: GSE153366
Toxicology Letters (2020) DOI: https://doi.org/10.1016/j.toxlet.2020.07.016 PMID: 32679240
GEO: GSE153366
Study Data
Toxicity and Carcinogenicity Studies
5-Day Evaluation of the Toxicity (C02047-01) of Tetrabromobisphenol A-bis(2,3-dibromopropyl ether)(21850-44-2) in Sprague Dawley Rats Exposed via Gavage
Study Data
- I01 - Animal Removal Summary (29 kB)
- I02 - Animal Removals (138 kB)
- I03 - Growth Curve (305 kB)
- I03C - Growth Curve (321 kB)
- I04 - Mean Body Weight Summary (74 kB)
- I04G - Mean Body Weight Gain (46 kB)
- I05 - Clinical Observations Summary (32 kB)
- PA02 - Neoplastic Lesion Summary with Percent Incidence (128 kB)
- PA03 - Non-Neoplastic Lesion Summary with Percent Incidence (101 kB)
- PA05 - Incidence Rates of Neoplastic Lesions with Systemic Lesions Abridged (129 kB)
- PA06 - Organ Weights Summary (87 kB)
- PA14 - Individual Animal Pathology Data (305 kB)
- PA18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grade (102 kB)
- PA41 - Clinical Chemistry Summary (146 kB)
- PA43 - Hematology Summary (153 kB)
- PA46 - Summary of Gross Pathology (226 kB)
- PA49 - Summary of Cytochrome Activity (52 kB)
- R07 - Hormone Summary (41 kB)
Individual Animal Data
- Individual Animal Body Weight Data (11 kB)
- Individual Animal Clinical Chemistry Data (9 kB)
- Individual Animal Clinical Observations Data (11 kB)
- Individual Animal Cytochrome Activity Data (8 kB)
- Individual Animal Gross Pathology Data (61 kB)
- Individual Animal Hematology Data (10 kB)
- Individual Animal Histopathology Data (5 kB)
- Individual Animal Hormone Data (6 kB)
- Individual Animal Organ Weight Data (8 kB)
- Individual Animal Removal Reasons Data (5 kB)
3-Month Evaluation of the Toxicity (C20321) of Tetrabromobisphenol A-bis(2,3-dibromopropyl Ether) (21850-44-2) in F344/NTac Rats Exposed via Gavage
Study Tables
- E03 - Growth Curves (512 kB)
- E04 - Mean Body Weights and Survival Table (30 kB)
- E05 - Clinical Observations Summary (39 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (231 kB)
- P04 - Neoplasms by Individual Animal (411 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (92 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (232 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (166 kB)
- P14 - Individual Animal Pathology Data (234 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (35 kB)
- P40 - Survival Curves (568 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (35 kB)
- Female Individual Animal Clinical Observations (2 kB)
- Female Individual Animal Non Neoplastic Pathology Data (79 kB)
- Female Individual Animal Organ Weight Data (19 kB)
- Female Individual Animal Survival Data (11 kB)
- Male Individual Animal Body Weight Data (35 kB)
- Male Individual Animal Clinical Observations (5 kB)
- Male Individual Animal Non Neoplastic Pathology Data (114 kB)
- Male Individual Animal Organ Weight Data (19 kB)
- Male Individual Animal Survival Data (11 kB)
3-Month Evaluation of the Toxicity (C20321) of Tetrabromobisphenol A-bis(2,3-dibromopropyl Ether) (21850-44-2) in B6C3F1 Mice Exposed via Gavage
Study Tables
- E03 - Growth Curves (518 kB)
- E04 - Mean Body Weights and Survival Table (95 kB)
- E05 - Clinical Observations Summary (13 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (59 kB)
- P04 - Neoplasms by Individual Animal (415 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (47 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (386 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (64 kB)
- P14 - Individual Animal Pathology Data (511 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (44 kB)
- P40 - Survival Curves (566 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (34 kB)
- Female Individual Animal Non Neoplastic Pathology Data (13 kB)
- Female Individual Animal Organ Weight Data (19 kB)
- Female Individual Animal Survival Data (11 kB)
- Male Individual Animal Body Weight Data (34 kB)
- Male Individual Animal Non Neoplastic Pathology Data (10 kB)
- Male Individual Animal Organ Weight Data (19 kB)
- Male Individual Animal Survival Data (11 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Tetrabromobisphenol A-bis(2,3-Dibromopropyl Ether) (21850-44-2) in Micronucleus Study A90104 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Tetrabromobisphenol A-bis(2,3-Dibromopropyl Ether) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A44427
Summary Data
- G06 - Ames Summary Data (57 KB)