WY-14643 (50892-23-4)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4020290
Publications
TOX-62
Toxicity Studies of WY-14,643 (CAS No. 50892-23-4) Administered in Feed to Male Sprague-Dawley Rats, B6C3F1 Mice, and Syrian Hamsters
TOX-96
NTP Report on the Toxicity Studies of Perfluorinated Compounds: Sulfonates Administered via Oral Gavage in Hsd: Sprague Dawley SD Rats
TOX-97
NTP Report on the Toxicity Studies of Perfluorinated Compounds: Carboxylates Administered via Oral Gavage in Hsd: Sprague Dawley SD Rats
Unraveling Human Hepatocellular Responses to PFAS and Aqueous Film-Forming Foams (AFFFs) for Molecular Hazard Prioritization and In Vivo Translation
Kevin A. Mauge-Lewis1,‡, Sreenivasa C. Ramaiahgari1,‡, Scott S. Auerbach1, Georgia K. Roberts1, Suramya Waidyanatha1, Suzanne E Fenton1, Dhiral P. Phadke2, Michele R. Balik-Meisner2, Arpit Tandon2, Deepak Mav2, Brian Howard2, Ruchir Shah2, Barney Sparrow3, Jenni Gorospe3, Stephen S. Ferguson1
‡These authors equally contributed to this study.
1Division of Translational Toxicology at the National Institute for Environmental Sciences, Research Triangle Park, North Carolina
2Sciome, Research Triangle Park, North Carolina
3Battelle, Columbus, Ohio
Environmental Science and Technology, (2025) DOI: https://doi.org/10.1021/acs.est.4c10595 PMID: 398893674 PMCID: PMC11823446
DOI: https://doi.org/10.22427/NTP-DATA-500-017-001-000-4
‡These authors equally contributed to this study.
1Division of Translational Toxicology at the National Institute for Environmental Sciences, Research Triangle Park, North Carolina
2Sciome, Research Triangle Park, North Carolina
3Battelle, Columbus, Ohio
Environmental Science and Technology, (2025) DOI: https://doi.org/10.1021/acs.est.4c10595 PMID: 398893674 PMCID: PMC11823446
DOI: https://doi.org/10.22427/NTP-DATA-500-017-001-000-4
Study Data
Toxicity and Carcinogenicity Studies
28-Day Evaluation of the Toxicity (C91069) of Wyeth 14,643 (WY) (50892-23-4) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
- E01 - Animal Removal Summary By Treatment Group (12 kB)
- E02 - Animals Removed from Experiment (47 kB)
- E03 - Growth Curves (346 kB)
- E04 - Mean Body Weights and Survival Table (15 kB)
- E05 - Clinical Observations Summary (12 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (34 kB)
- P04 - Neoplasms by Individual Animal (165 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (33 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (171 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (134 kB)
- P11 - Statistical Analysis of Survival Data (23 kB)
- P14 - Individual Animal Pathology Data (196 kB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (166 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (33 kB)
- P40 - Survival Curves (387 kB)
- PA06 - Organ Weights Summary (95 kB)
- PA41 - Clinical Chemistry Summary (206 kB)
- PA43 - Hematology Summary (185 kB)
- PA45 - Liver Special Studies Summary (30 kB)
- R06 - Andrology Summary (50 kB)
- R07 - Hormone Summary (50 kB)
- Results of Vaginal Cytology Study Using Transition Matrix Approach (43 kB)
- Summary of Estrous Stages and Cycle Data (54 kB)
- Vaginal Cytology Plot (17 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (13 kB)
- Female Individual Animal Non Neoplastic Pathology Data (25 kB)
- Female Individual Animal Survival Data (8 kB)
- Female Individual Animal Terminal Body Weight Data (13 kB)
- Individual Animal Andrology Data (7 kB)
- Individual Animal Clinical Chemistry Data (12 kB)
- Individual Animal Hematology Data (14 kB)
- Individual Animal Hormone Data (9 kB)
- Individual Animal Liver Special Studies Data (5 kB)
- Individual Animal Organ Weight Data (12 kB)
- Individual Vaginal Cytology Data (24 kB)
- Individual_Animal_PCR_Data (20 kB)
- Male Individual Animal Body Weight Data (13 kB)
- Male Individual Animal Non Neoplastic Pathology Data (33 kB)
- Male Individual Animal Survival Data (8 kB)
- Male Individual Animal Terminal Body Weight Data (13 kB)
- Male Individual Clinical Observations (2 kB)
3-Month Evaluation of the Toxicity (C55550E) of Methapyrilene hydrochloride (135-23-9) in F344 Rats Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C93027D) of Peroxisome Project (WY-14643) (50892-23-4) in Sprague-Dawley Rats Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C93027D) of Peroxisome Project (WY-14643) (50892-23-4) in Sprague-Dawley Rats Exposed via Dosed Feed. NTP Special Study
2-Week Evaluation of the Toxicity (C93027D) of Peroxisome Project (WY-14643) (50892-23-4) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
3-Month Evaluation of the Toxicity (C93027D) of Peroxisome Project (WY-14643) (50892-23-4) in B6C3F1 Mice Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C93027D) of Peroxisome Project (WY-14643) (50892-23-4) in B6C3F1 Mice Exposed via Dosed Feed. NTP Special Study
2-Week Evaluation of the Toxicity (C93027D) of Peroxisome Project (WY-14643) (50892-23-4) in Syrian Golden Hamsters Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
3-Month Evaluation of the Toxicity (C93027D) of Peroxisome Project (WY-14643) (50892-23-4) in Syrian Golden Hamsters Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C93027D) of Peroxisome Project (WY-14643) (50892-23-4) in Syrian Golden Hamsters Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C93027D) of Peroxisome Project (WY-14643) (50892-23-4) in Harlan Sprague-Dawley Rats Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
Individual Animal Data
3-Month Evaluation of the Toxicity (C93027D) of Peroxisome Project (WY-14643) (50892-23-4) in Harlan Sprague-Dawley Rats Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C93027D) of Peroxisome Project (WY-14643) (50892-23-4) in Harlan Sprague-Dawley Rats Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C93027D) of Peroxisome Project (WY-14643) (50892-23-4) in B6C3F1 Mice Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C93027D) of Peroxisome Project (WY-14643) (50892-23-4) in B6C3F1 Mice Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C93027D) of Peroxisome Project (WY-14643) (50892-23-4) in B6C3F1 Mice Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
Individual Animal Data
3-Month Evaluation of the Toxicity (C93027D) of Peroxisome Project (WY-14643) (50892-23-4) in Syrian Golden Hamsters Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C93027D) of Peroxisome Project (WY-14643) (50892-23-4) in Syrian Golden Hamsters Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C93027D) of Peroxisome Project (WY-14643) (50892-23-4) in Syrian Golden Hamsters Exposed via Dosed Feed
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
Individual Animal Data
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Peroxisome Project (WY-14643) (50892-23-4) in Micronucleus Study A06279 in Tg.AC (FVB/N) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Peroxisome Project (WY-14643) (50892-23-4) in Micronucleus Study A71798 in Tg.AC (FVB/N) Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Peroxisome Project (WY-14643) (50892-23-4) in Micronucleus Study G91069 in Harlan Sprague-Dawley Rats
Summary and Individual Animal Data
Other NTP Studies
Toxicokinetic Evaluation (S0583) of Wyeth-14643 (DTXSID4020290) in Rat, Mouse and Hamster
Toxicokinetic Evaluation (S0629) of Wyeth-14643 (DTXSID4020290) in Rat, Mouse and Hamster
Data
- Annotated Group Parameters (20 kB)
- Annotated Individual Animal Data (207 kB)
- Original Data (67 kB)
- Summary Data - Hamsters (206 kB)
- Summary Data - Mice (198 kB)
- Summary Data - Rats (200 kB)