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2,4-Dimethoxyaniline hydrochloride (54150-69-5)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID1020483


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Negative, Male, Rats
View
  • Negative, Female, Rats

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 2,4-Dimethoxyaniline hydrochloride (54150-69-5).
Micronucleus - Mice
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 2,4-Dimethoxyaniline hydrochloride (54150-69-5).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 2,4-Dimethoxyaniline hydrochloride (54150-69-5).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 2,4-Dimethoxyaniline hydrochloride (54150-69-5).
Bacterial Mutagenicity
View
  • Positive

Citation Information


NTP. 2,4-Dimethoxyaniline hydrochloride (54150-69-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-171 Bioassay of 2,4-Dimethoxyaniline Hydrochloride for Possible Carcinogenicity (CASRN 54150-69-5)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of 2,4-Dimethoxyaniline Hydrochloride (54150-69-5) in Male F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,4-Dimethoxyaniline Hydrochloride (54150-69-5) in Female F344 Rats Exposed via Dosed Feed

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 2,4-Dimethoxyaniline Hydrochloride (54150-69-5) in Micronucleus Study 756856 in B6C3F1 Mice
Genetic Toxicity Evaluation of 2,4-Dimethoxyaniline Hydrochloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 792648
Summary Data