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Glycidol (556-52-5)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4020666


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Male, Rats
View
  • Clear Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Male, Mice
View
  • Clear Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Glycidol (556-52-5).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
View
  • Male: Negative
    Female: Negative
View
  • Male: Positive
    Female: Positive
View
  • Male: Positive
    Female: Positive
View
  • Male: Negative
    Female: Negative
View
  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Glycidol (556-52-5).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Glycidol (556-52-5).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Glycidol (556-52-5).
Drosophila Germ Cell Mutagenicity
SLRL RT
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Glycidol (556-52-5).
Bacterial Mutagenicity
View
  • Positive
View
  • Positive

Citation Information


NTP. Glycidol (556-52-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-374 Toxicology and Carcinogenesis Studies of Glycidol (CASRN 556-52-5) In F344/N Rats and B6C3F1 Mice (Gavage Studies)
Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
GMM-13 Toxicology and Carcinogenesis Study of Glycidol (CASRN 556-52-5) in Genetically Modified Haploinsufficient p16Ink4a/p19Arf Mice (Gavage Study)
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227

Study Data


Toxicity and Carcinogenicity Studies


40-Week Evaluation of the Toxicity (C99035) of Transgenic Model II (Glycidol) (556-52-5) in P16(INK4A)/(+/-) (C57BL/6) Mice Exposed via Gavage. NTP Special Study
26-39 Week Evaluation of the Toxicity (C99035) of Transgenic Model II (Glycidol) (556-52-5) in Tg.P16-INK4A Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Glycidol (556-52-5) in Male F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Glycidol (556-52-5) in Female F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Glycidol (556-52-5) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Glycidol (556-52-5) in Female B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Glycidol (556-52-5) in Micronucleus Study 196476 in B6C3F1 Mice
Genetic Toxicity Evaluation of Glycidol (556-52-5) in Micronucleus Study A37837 in P16(INK4A)/(+/-) (C57BL/6) Mice
Genetic Toxicity Evaluation of Glycidol (556-52-5) in Micronucleus Study A48958 in P16(INK4A)/(+/-) (C57BL/6) Mice
Genetic Toxicity Evaluation of Glycidol (556-52-5) in Micronucleus Study A58625 in P16(INK4A)/(+/-) (C57BL/6) Mice
Genetic Toxicity Evaluation of Glycidol (556-52-5) in Micronucleus Study A75768 in P16(INK4A)/(+/-) (C57BL/6) Mice
Genetic Toxicity Evaluation of Glycidol (556-52-5) in Micronucleus Study A92101 in P16(INK4A)/(+/-) (C57BL/6) Mice
Genetic Toxicity Evaluation of Glycidol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 278371
Summary Data
Genetic Toxicity Evaluation of Glycidol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 971355
Summary Data

Other NTP Studies


14-Day Immunotoxicity Evaluation (IMM91019) of Glycidol (556-52-5) in B6C3F1 Mice via Gavage
ADME/TK Evaluation (S0161) of Glycidol (556-52-5) in F344 Rats Exposed via Intravenous Injection or Gavage Administration