Glycidol (556-52-5)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4020666

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View Clear Evidence, Male, Rats
View Clear Evidence, Female, Rats

An overview of chronic evidence from Mice studies.
Mice
View Clear Evidence, Male, Mice
View Clear Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Glycidol (556-52-5).
Micronucleus - Mice
View Male: Negative Female: Negative
View Male: Negative Female: Negative
View Male: Positive Female: Positive
View Male: Positive Female: Positive
View Male: Negative Female: Negative
View Male: Positive

An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Glycidol (556-52-5).
Mammalian Cell Mutagenicity
View Positive

An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Glycidol (556-52-5).
Mammalian Cell Cytogenetics
CA	SCE
View Positive	View Positive

An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Glycidol (556-52-5).
Drosophila Germ Cell Mutagenicity
SLRL	RT
View Positive	View Positive

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Glycidol (556-52-5).
Bacterial Mutagenicity
View Positive
View Positive

Citation Information

NTP. Glycidol (556-52-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

TR-374 Toxicology and Carcinogenesis Studies of Glycidol (CASRN 556-52-5) In F344/N Rats and B6C3F1 Mice (Gavage Studies)

[Abstract]

Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138

GMM-13 Toxicology and Carcinogenesis Study of Glycidol (CASRN 556-52-5) in Genetically Modified Haploinsufficient p16Ink4a/p19Arf Mice (Gavage Study)

[Abstract]

Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227

Study Data

Protocol

Toxicity and Carcinogenicity Studies

40-Week Evaluation of the Toxicity (C99035) of Transgenic Model II (Glycidol) (556-52-5) in P16(INK4A)/(+/-) (C57BL/6) Mice Exposed via Gavage. NTP Special Study

Pathology Tables

Individual Animal Data

Male Individual Animal Organ Weight Data

26-39 Week Evaluation of the Toxicity (C99035) of Transgenic Model II (Glycidol) (556-52-5) in Tg.P16-INK4A Mice Exposed via Gavage

Pathology Tables

Pathology Tables, Survival and Growth Curves

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity of Glycidol (556-52-5) in Male F344 Rats Exposed via Gavage

Pathology Tables

Pathology Tables, Survival and Growth Curves

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity of Glycidol (556-52-5) in Female F344 Rats Exposed via Gavage

Pathology Tables

Pathology Tables, Survival and Growth Curves

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity of Glycidol (556-52-5) in Male B6C3F1 Mice Exposed via Gavage

Pathology Tables

Pathology Tables, Survival and Growth Curves

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity of Glycidol (556-52-5) in Female B6C3F1 Mice Exposed via Gavage

Pathology Tables

Pathology Tables, Survival and Growth Curves

Individual Animal Data

Protocol

Genetic Toxicity Evaluation of Glycidol (556-52-5) in Micronucleus Study 196476 in B6C3F1 Mice

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (82 KB)
Individual Animal In Vivo Micronucleus Data (10 KB)

Data

Genetic Toxicity Evaluation of Glycidol (556-52-5) in Micronucleus Study A37837 in P16(INK4A)/(+/-) (C57BL/6) Mice

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (65 KB)
Individual Animal In Vivo Micronucleus Data (14 KB)

Data

Genetic Toxicity Evaluation of Glycidol (556-52-5) in Micronucleus Study A48958 in P16(INK4A)/(+/-) (C57BL/6) Mice

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (65 KB)
Individual Animal In Vivo Micronucleus Data (14 KB)

Data

Genetic Toxicity Evaluation of Glycidol (556-52-5) in Micronucleus Study A58625 in P16(INK4A)/(+/-) (C57BL/6) Mice

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (65 KB)
Individual Animal In Vivo Micronucleus Data (14 KB)

Data

Genetic Toxicity Evaluation of Glycidol (556-52-5) in Micronucleus Study A75768 in P16(INK4A)/(+/-) (C57BL/6) Mice

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (65 KB)
Individual Animal In Vivo Micronucleus Data (14 KB)

Data

Genetic Toxicity Evaluation of Glycidol (556-52-5) in Micronucleus Study A92101 in P16(INK4A)/(+/-) (C57BL/6) Mice

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (65 KB)
Individual Animal In Vivo Micronucleus Data (12 KB)

Genetic Toxicity Evaluation of Glycidol in Drosophila Reciprocal Translocations Test

Genetic Toxicity Evaluation of Glycidol in Drosophila Sex-Linked Recessive Lethal Mutations Test

Data

Genetic Toxicity Evaluation of Glycidol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 278371

Summary Data

G06 - Ames Summary Data (146 KB)

Data

Genetic Toxicity Evaluation of Glycidol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 971355

Summary Data

G06 - Ames Summary Data (148 KB)

Other NTP Studies

Data

14-Day Immunotoxicity Evaluation (IMM91019) of Glycidol (556-52-5) in B6C3F1 Mice via Gavage

B6CF1 Mice Individual and Summary Data

Absolute Leukocyte Differentials (13 kB)
Body Weights (87 kB)
Hematology (13 kB)
Host Resistance to B16F10 Melanoma Tumors (4 kB)
In Vitro Cytotoxic T Lymphocyte (CTL) Assay (13 kB)
Lymphocyte Proliferation (13 kB)
Mixed Leukocyte Response (9 kB)
Natural Killer Activity (10 kB)
Organ Weights (20 kB)
Resistance to Infection with Listeria Monocytogenes (28 kB)
Resistance to Infection with Streptococcus Pneumoniae (28 kB)
Reticulocytes (8 kB)
Surface Markers (%) (12 kB)
Surface Markers (Absol) (11 kB)
T-Dependent AB Response Day 4 (12 kB)

Data

ADME/TK Evaluation (S0161) of Glycidol (556-52-5) in F344 Rats Exposed via Intravenous Injection or Gavage Administration

Data Summary

IV Gavage Excreta and Tissue Distribution (332 kB)

Glycidol (556-52-5)

Study Results

Chronic Bioassay Level of Evidence

Genetic Toxicology

Citation Information

Related Links

Publications

Study Data

Toxicity and Carcinogenicity Studies

40-Week Evaluation of the Toxicity (C99035) of Transgenic Model II (Glycidol) (556-52-5) in P16(INK4A)/(+/-) (C57BL/6) Mice Exposed via Gavage. NTP Special Study

Pathology Tables

Individual Animal Data

26-39 Week Evaluation of the Toxicity (C99035) of Transgenic Model II (Glycidol) (556-52-5) in Tg.P16-INK4A Mice Exposed via Gavage

Pathology Tables

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity of Glycidol (556-52-5) in Male F344 Rats Exposed via Gavage

Pathology Tables

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity of Glycidol (556-52-5) in Female F344 Rats Exposed via Gavage

Pathology Tables

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity of Glycidol (556-52-5) in Male B6C3F1 Mice Exposed via Gavage

Pathology Tables

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity of Glycidol (556-52-5) in Female B6C3F1 Mice Exposed via Gavage

Pathology Tables

Individual Animal Data

Genetic Toxicology Studies

Cytogenetic Study of Glycidol in Chinese Hamster Ovary Cell Chromosome Aberrations Test

Cytogenetic Study of Glycidol in Chinese Hamster Ovary Cell Sister Chromatid Exchange Test

Effects of Glycidol in Mouse Lymphoma. Study 036941

Genetic Toxicity Evaluation of Glycidol (556-52-5) in Micronucleus Study 196476 in B6C3F1 Mice

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Glycidol (556-52-5) in Micronucleus Study A37837 in P16(INK4A)/(+/-) (C57BL/6) Mice

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Glycidol (556-52-5) in Micronucleus Study A48958 in P16(INK4A)/(+/-) (C57BL/6) Mice

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Glycidol (556-52-5) in Micronucleus Study A58625 in P16(INK4A)/(+/-) (C57BL/6) Mice

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Glycidol (556-52-5) in Micronucleus Study A75768 in P16(INK4A)/(+/-) (C57BL/6) Mice

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Glycidol (556-52-5) in Micronucleus Study A92101 in P16(INK4A)/(+/-) (C57BL/6) Mice

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Glycidol in Drosophila Reciprocal Translocations Test

Genetic Toxicity Evaluation of Glycidol in Drosophila Sex-Linked Recessive Lethal Mutations Test

Genetic Toxicity Evaluation of Glycidol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 278371

Summary Data

Genetic Toxicity Evaluation of Glycidol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 971355

Summary Data

Other NTP Studies

14-Day Immunotoxicity Evaluation (IMM91019) of Glycidol (556-52-5) in B6C3F1 Mice via Gavage

B6CF1 Mice Individual and Summary Data

ADME/TK Evaluation (S0161) of Glycidol (556-52-5) in F344 Rats Exposed via Intravenous Injection or Gavage Administration

Data Summary

NTP Data Collections