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Theophylline (58-55-9)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID5021336


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Female, Rats
  • No Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Theophylline (58-55-9).
Rodent Cytogenetics
CA SCE
  • View
    • Positive (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Theophylline (58-55-9).
Micronucleus - Mice
View
  • Male: Positive
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Theophylline (58-55-9).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Theophylline (58-55-9).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. Theophylline (58-55-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-473 Toxicology and Carcinogenesis Studies of Theophylline (CASRN 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies)
McFee, A.F. Chromosomal effects of theophylline measured in mouse marrow cells in vivo. Mutat. Res. Vol. 264 (1991) 219-224
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
Teratologic Evaluation of Theophylline Administered to CD-1 Mice on Gestational Days 6 through 15
Teratologic Evaluation of Theophylline Administered to CD® Rats on Gestational Days 6 through 15
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
McFee, A.F. Chromosomal effects of theophylline measured in mouse marrow cells in vivo. Mutat. Res. Vol. 264 (1991) 219-224

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C61609A) of Theophylline (58-55-9) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C61609B) of Theophylline (58-55-9) in F344/N Rats Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C61609A) of Theophylline (58-55-9) in B6C3F1 Mice Exposed via Gavage
3-Month Evaluation of the Toxicity (C61609B) of Theophylline (58-55-9) in B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity (C61609C) of Theophylline (58-55-9) in F344/N Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C61609D) of Theophylline (58-55-9) in F344/N Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C61609C) of Theophylline (58-55-9) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C61609D) of Theophylline (58-55-9) in B6C3F1 Mice Exposed via Gavage

Other NTP Studies


Prenatal Developmental Toxicity Study (TER84110) of Theophylline (58-55-9) in Sprague Dawley Rats Exposed via Dosed Feed
Prenatal Developmental Toxicity Study (TER84111) of Theophylline (58-55-9) in Swiss CD-1 Mice Exposed via Dosed Water