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Diisopropylcarbodiimide (693-13-0)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4025086


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Female, Rats
  • No Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Rats study conclusions related to Diisopropylcarbodiimide (693-13-0).
Micronucleus - Rats
View
  • Male: Negative
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Diisopropylcarbodiimide (693-13-0).
Micronucleus - Mice
View
  • Male: Equivocal
View
  • Male: Positive
View
  • Male: Positive
    Female: Positive
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Diisopropylcarbodiimide (693-13-0).
Bacterial Mutagenicity
View
  • Negative
View
  • Equivocal

Citation Information


NTP. Diisopropylcarbodiimide (693-13-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-523 Toxicology and Carcinogenesis Studies of Diisopropylcarbodiimide (CASRN 693-13-0) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
Witt, K.L., Tice, R.R., Shelby, M.D., Chhabra, R.S., and Zeiger, E. Induction of Micronucleated Erythrocytes in Rodents by Diisopropylcarbodiimide and Dicyclohexylcarbodiimide: Dependence on Exposure Protocol. Environ. Molec. Mutag. Vol. 33 (1999) 65-74
GMM-10 Toxicology Study of Diispropylcarbodiimide (CASRN 693-13-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Diispropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Dermal Studies)

Study Data


Toxicity and Carcinogenicity Studies


150-Day Evaluation of the Toxicity (C93020B) of Diisopropylcarbodiimide (693-13-0) in Tg.AC Mice Exposed via Topical Application
2-Week Evaluation of the Toxicity (C93020) of Diisopropylcarbodiimide (693-13-0) in F344/N Rats Exposed via Topical Application
3-Month Evaluation of the Toxicity (C93020) of Diisopropylcarbodiimide (693-13-0) in F344 Rats Exposed via Topical Application. NTP Special Study
2-Week Evaluation of the Toxicity (C93020) of Diisopropylcarbodiimide (693-13-0) in B6C3F1 Mice Exposed via Topical Application
3-Month Evaluation of the Toxicity (C93020) of Diisopropylcarbodiimide (693-13-0) in B6C3F1 Mice Exposed via Topical Application. NTP Special Study
26-Week Evaluation of the Toxicity (C93020C) of Diisopropylcarbodiimide (693-13-0) in P53(C57BL/6) Mice Exposed via Topical Application
3-Month Evaluation of the Toxicity (C93020) of Diisopropylcarbodiimide (693-13-0) in F344/N Rats Exposed via Topical Application
3-Month Evaluation of the Toxicity (C93020) of Diisopropylcarbodiimide (693-13-0) in B6C3F1 Mice Exposed via Topical Application
Evaluation of the Chronic Toxicity and Carcinogenicity (C93020D) of Diisopropylcarbodiimide (693-13-0) in F344/N Rats Exposed via Topical Application
Evaluation of the Chronic Toxicity and Carcinogenicity (C93020D) of Diisopropylcarbodiimide (693-13-0) in B6C3F1 Mice Exposed via Topical Application

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Diisopropylcarbodiimide (693-13-0) in Micronucleus Study A04322 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Diisopropylcarbodiimide (693-13-0) in Micronucleus Study A22799 in B6C3F1 Mice
Genetic Toxicity Evaluation of Diisopropylcarbodiimide (693-13-0) in Micronucleus Study A55884 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Diisopropylcarbodiimide (693-13-0) in Micronucleus Study A76999 in F344 Rats
Genetic Toxicity Evaluation of Diisopropylcarbodiimide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A69920
Summary Data
Genetic Toxicity Evaluation of Diisopropylcarbodiimide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A92772
Summary Data

Other NTP Studies


ADME/TK Evaluation (S0662) of Diisopropylcarbodiimide (693-13-0) in F344 Rats and B6C3F1 Mice Exposed via Intravenous Injection or Topical Application